The Effect of Helium and Oxygen on Exercise Performance in Chronic Obstructive Pulmonary Disease

Laude, E; Duffy, N; Baveystock, C M; Dougill, Beatriz; Campbell, Mike; Lawson, Rod; Jones, Paul; Calverley, P. M. A.

doi:10.1164/rccm.200506-925oc

Cited by 96 publications

(68 citation statements)

References 38 publications

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“…As a result of their decreased density, heliumcontaining gas mixtures reduce the resistance to airflow, which in turn may decrease the work of breathing, reduce the severity of hyperinflation, increase exercise capacity, and decrease dyspnea in patients with obstructive lung disease (231)(232)(233). A single study suggests a beneficial effect in patients with lung cancer, although all the patients in the study had coexistent airflow obstruction (234).…”

Section: Treatmentmentioning

confidence: 99%

An Official American Thoracic Society Statement: Update on the Mechanisms, Assessment, and Management of Dyspnea

Parshall¹,

Schwartzstein²,

Adams³

et al. 2012

Am J Respir Crit Care Med

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1,477

1,328

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Section: Treatmentmentioning

confidence: 99%

An Official American Thoracic Society Statement: Update on the Mechanisms, Assessment, and Management of Dyspnea

Parshall¹,

Schwartzstein²,

Adams³

et al. 2012

Am J Respir Crit Care Med

Self Cite

1,477

1,328

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“…Reducing the gas density with heliox has also been shown to reduce ventilation and improve exercise capacity [139]. The reduction in ventilation improves expiratory flow and reduces dynamic hyperinflation, thereby decreasing the operational lung volume and reducing the work of breathing [140].…”

Section: Breathed Mixturesmentioning

confidence: 99%

Nonpharmacological treatment and relief of symptoms in COPD

Clini

Ambrosino²

2008

European Respiratory Journal

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Evidence-based guidelines for chronic obstructive pulmonary disease (COPD) have recently been developed.Nonpharmacological treatments have evolved rapidly as an essential part of COPD therapy. They are especially important as complementary interventions in severe or very severe disease, when there is loss in function, a reduction in quality of life and when psychological impairments further complicate the disease.The present article discusses the most used nonpharmacological treatments for severe COPD patients (rehabilitation, long-term oxygen therapy, surgery, noninvasive positive pressure ventilation and supportive nutrition) and their evidence-based usefulness in promoting strategies that relieve symptoms.All of these interventions are used during end-stage disease, to promote self-efficacy, relieve symptoms and prevent further deterioration. These therapeutic options support physicians and allied professionals in improving symptom management for their patients.

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“…Reducing inspired gas density has been shown to double endurance time for constant work rate ergometer exercise tests in chronic obstructive airway patients [10,11].…”

Section: Discussionmentioning

confidence: 99%

A novel ambulatory closed circuit breathing system for use during exercise

McMorrow¹,

Windsor²,

Mythen³

et al. 2011

Anaesthesia

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Summary We describe a unique ambulatory closed circuit for delivering high fractions of inspired oxygen to an exercising user who does not require isolation from their environment. We describe the major components and their function and suggest potential applications for such a circuit. This circuit may benefit patients who are chronically dependant on oxygen, are unable to exercise due to hypoxia, or require oxygen supplementation at high altitude.

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The Effect of Helium and Oxygen on Exercise Performance in Chronic Obstructive Pulmonary Disease

Abstract: Reducing inspired gas density can improve exercise performance in COPD as much as increasing inspired oxygen. These effects can be combined as Heliox28 and are most evident in patients with more severe airflow obstruction.

Cited by 96 publications

References 38 publications

An Official American Thoracic Society Statement: Update on the Mechanisms, Assessment, and Management of Dyspnea

An Official American Thoracic Society Statement: Update on the Mechanisms, Assessment, and Management of Dyspnea

Nonpharmacological treatment and relief of symptoms in COPD

A novel ambulatory closed circuit breathing system for use during exercise

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