The effect of glyphosate-based herbicide Roundup and its co-formulant, POEA, on the motoric activity of rat intestine – In vitro study

Chłopecka, Magdalena; Mendel, Marta; Dziekan, Natalia; Karlik, Wojciech

doi:10.1016/j.etap.2016.12.010

Cited by 27 publications

(12 citation statements)

References 35 publications

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“…39 Unfortunately, these ingredients have been declared inert by the industry and are excluded from toxicity tests, but studies have shown that the toxicity of the herbicide formulation may not be due to glyphosate alone. [40][41][42] In recent years, the influence of diet on the reproductive system of rodents has been discussed, due to the fact that estrogenic activity is associated with the use of soybeans in animal feed, making this food a potential EDC. 43 A limitation of the current study is that we did not evaluate effects of the diet, and further investigations into such effects are necessary.…”

Section: Discussionmentioning

confidence: 99%

Glyphosate-based herbicide exposure during pregnancy and lactation malprograms the male reproductive morphofunction in F1 offspring

Teleken

Gomes

Marmentini

et al. 2019

J Dev Orig Health Dis

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One of the most consumed pesticides in the world is glyphosate, the active ingredient in the herbicide ROUNDUP®. Studies demonstrate that glyphosate can act as an endocrine disruptor and that exposure to this substance at critical periods in the developmental period may program the fetus to induce reproductive damage in adulthood. Our hypothesis is that maternal exposure to glyphosate during pregnancy and lactation in mice will affect the development of male reproductive organs, impairing male fertility during adult life. Female mice consumed 0.5% glyphosate-ROUNDUP® in their drinking water [glyphosate-based herbicide (GBH) group] or filtered water [control (CTRL) group] from the fourth day of pregnancy until the end of the lactation period. Male F1 offspring were designated, according to their mother’s treatment, as CTRL-F1 and GBH-F1. Female mice that drank glyphosate displayed reduced body weight (BW) gain during gestation, but no alterations in litter size. Although GBH male F1 offspring did not exhibit modifications in BW, they demonstrated delayed testicular descent. Furthermore, at PND150, GBH-F1 mice presented a lower number of spermatozoa in the cauda epididymis and reduced epithelial height of the seminiferous epithelium. Notably, intratesticular testosterone concentrations were enhanced in GBH-F1 mice; we show that it is an effect associated with increased plasma and pituitary concentrations of luteinizing hormone. Therefore, data indicate that maternal exposure to glyphosate-ROUNDUP® during pregnancy and lactation may lead to decreased spermatogenesis and disruptions in hypothalamus–pituitary–testicular axis regulation in F1 offspring.

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Section: Discussionmentioning

confidence: 99%

Glyphosate-based herbicide exposure during pregnancy and lactation malprograms the male reproductive morphofunction in F1 offspring

Teleken

Gomes

Marmentini

et al. 2019

J Dev Orig Health Dis

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“…caused a testosterone-disruptor effect (Romano et al, 2012). In addition, nephrotoxicity (Hamdaoui et al, 2016), hepatotoxicity (ElShenawy, 2009;Haskovic et al, 2016;Tang et al, 2017;Lozano et al, 2018), neurotoxicity on dopaminergic markers (Hernández-Plata et al, 2015;Martínez et al, 2018), and on the immature rat hippocampus (Cattani et al, 2014), effects on intestine peristalsis (Chłopecka et al, 2014(Chłopecka et al, , 2017, sperm quality (Abarikwu et al, 2015;Dai et al, 2016) and reproductive toxicity (Owagboriaye et al, 2017), estrogenic effects (Vandenberg et al, 2012;Varayoud et al, 2017) and the effect of neonatal exposure to female adult reproductive performance (Ingaramo et al, 2016 have been demonstrated. Liver dysfunction observed in rats correlated with gut microbiome disturbances identified in a recent study : longterm effects of Roundup Grand Travaux Plus R at 3 doses (corresponding to glyphosate concentrations of 50 ng/l, 100 µg/l, and 2.25 g/l) on the gut microbiota in Sprague-Dawley rats were observed by determining 141 bacteria families by highthroughput sequencing, of which alteration of the Firmicutes to Bacteroidetes ratio was recorded at different levels in females (but not in males).…”

Section: Registration Of Glyphosate In the European Unionmentioning

confidence: 99%

Re-registration Challenges of Glyphosate in the European Union

Székacs

Darvas

2018

Front. Environ. Sci.

104

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“…For example, it has been shown that Roundup is more toxic than glyphosate alone [17]. Roundup includes the co-formulant polyetholoxylated tallow amine (POEA) which appears to be the ingredient with the greatest toxic effects [18,19]. polyetholoxylated tallow amine (POEA) which appears to be the ingredient with the greatest toxic effects [18,19].…”

Section: Glyphosate Action and Contamination Routesmentioning

confidence: 99%

“…Roundup includes the co-formulant polyetholoxylated tallow amine (POEA) which appears to be the ingredient with the greatest toxic effects [18,19]. polyetholoxylated tallow amine (POEA) which appears to be the ingredient with the greatest toxic effects [18,19]. polyetholoxylated tallow amine (POEA) which appears to be the ingredient with the greatest toxic effects [18,19].…”

Section: Glyphosate Action and Contamination Routesmentioning

confidence: 99%

Pleiotropic Outcomes of Glyphosate Exposure: From Organ Damage to Effects on Inflammation, Cancer, Reproduction and Development

Marino

Mele

Viggiano

et al. 2021

IJMS

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Glyphosate is widely used worldwide as a potent herbicide. Due to its ubiquitous use, it is detectable in air, water and foodstuffs and can accumulate in human biological fluids and tissues representing a severe human health risk. In plants, glyphosate acts as an inhibitor of the shikimate pathway, which is absent in vertebrates. Due to this, international scientific authorities have long-considered glyphosate as a compound that has no or weak toxicity in humans. However, increasing evidence has highlighted the toxicity of glyphosate and its formulations in animals and human cells and tissues. Thus, despite the extension of the authorization of the use of glyphosate in Europe until 2022, several countries have begun to take precautionary measures to reduce its diffusion. Glyphosate has been detected in urine, blood and maternal milk and has been found to induce the generation of reactive oxygen species (ROS) and several cytotoxic and genotoxic effects in vitro and in animal models directly or indirectly through its metabolite, aminomethylphosphonic acid (AMPA). This review aims to summarize the more relevant findings on the biological effects and underlying molecular mechanisms of glyphosate, with a particular focus on glyphosate's potential to induce inflammation, DNA damage and alterations in gene expression profiles as well as adverse effects on reproduction and development.

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The effect of glyphosate-based herbicide Roundup and its co-formulant, POEA, on the motoric activity of rat intestine – In vitro study

Cited by 27 publications

References 35 publications

Glyphosate-based herbicide exposure during pregnancy and lactation malprograms the male reproductive morphofunction in F1 offspring

Glyphosate-based herbicide exposure during pregnancy and lactation malprograms the male reproductive morphofunction in F1 offspring

Re-registration Challenges of Glyphosate in the European Union

Pleiotropic Outcomes of Glyphosate Exposure: From Organ Damage to Effects on Inflammation, Cancer, Reproduction and Development

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