The effect of gentle human touch on pain, comfort and physiological parameters in preterm infants during heel lancing

Efe, Yağmur Sezer; Erdem, Emine; Caner, Nuray; Güneş, Tamer

doi:10.1016/j.ctcp.2022.101622

Cited by 8 publications

(9 citation statements)

References 30 publications

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“…Figure 2 reported the results of the bias risk assessment for the included studies. Of the allocation concealment methods, 3 studies [ 53 , 56 , 58 ] were marked as high risk for not applying, 17 [ 29 – 31 , 36 , 39 – 42 , 44 , 46 , 48 , 49 , 51 , 52 , 54 , 55 , 62 ] were marked as unclear risk for not being mentioned in the study, and the remaining were marked as low risk. In the blinding of participants and personnel, 2 studies [ 58 , 59 ] took a high risk since they couldn’t apply the blinding, and 28 [ 29 – 32 , 35 , 36 , 38 – 42 , 44 – 57 , 60 , 62 , 63 ] were marked as unclear risk.…”

Section: Resultsmentioning

confidence: 99%

“…In the blinding of outcome assessment, 8 studies [ 29 , 30 , 33 , 35 , 47 , 48 , 51 , 52 ] were found to be marked as high risk for not applying the blinding and 10 [ 31 , 36 – 39 , 41 , 42 , 58 , 61 , 62 ] were marked as unclear risk. Among other bias, 1 study [ 56 ] was marked as high risk as the study personnel and outcome assessment was the same person. In addition, all studies explained the use of randomization methods and were accordingly marked as low risk.…”

Section: Resultsmentioning

confidence: 99%

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Effect of non-pharmacological interventions on pain in preterm infants in the neonatal intensive care unit: a network meta-analysis of randomized controlled trials

Weng,

Zhang,

Chen

2024

BMC Pediatr

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Objective To evaluate the effectiveness of different non-pharmacological interventions for pain management in preterm infants and provide high-quality clinical evidence. Methods Randomized controlled trials (RCTs) of various non-pharmacological interventions for pain management in preterm infants were searched from PubMed, Web of Science, Embase, and the Cochrane Library from 2000 to the present (updated March 2023). The primary outcome was pain score reported as standardized mean difference (SMD). The secondary outcomes were oxygen saturation and heart rate reported as the same form. Results Thirty five RCTs of 2134 preterm infants were included in the meta-analysis, involving 6 interventions: olfactory stimulation, combined oral sucrose and non-nutritive sucking (OS + NNS), facilitated tucking, auditory intervention, tactile relief, and mixed intervention. Based on moderate-quality evidence, OS + NNS (OR: 3.92, 95% CI: 1.72, 6.15, SUCRA score: 0.73), facilitated tucking (OR: 2.51, 95% CI: 1.15, 3.90, SUCRA score: 0.29), auditory intervention (OR: 2.48, 95% CI: 0.91, 4.10, SUCRA score: 0.27), olfactory stimulation (OR: 1.80, 95% CI: 0.51, 3.14, SUCRA score: 0.25), and mixed intervention (OR: 2.26, 95% CI: 0.10, 4.38, SUCRA score: 0.14) were all superior to the control group for pain relief. For oxygen saturation, facilitated tucking (OR: 1.94, 95% CI: 0.66, 3.35, SUCRA score: 0.64) and auditory intervention (OR: 1.04, 95% CI: 0.22, 2.04, SUCRA score: 0.36) were superior to the control. For heart rate, none of the comparisons between the various interventions were statistically significant. Conclusion This study showed that there are notable variations in the effectiveness of different non-pharmacological interventions in terms of pain scores and oxygen saturation. However, there was no evidence of any improvement in heart rate.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Effect of non-pharmacological interventions on pain in preterm infants in the neonatal intensive care unit: a network meta-analysis of randomized controlled trials

Weng,

Zhang,

Chen

2024

BMC Pediatr

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“…Many repeated pain stimuli will cause stress reactions to the body, leading to a series of short-term and long-term adverse effects on neonates. [ 6 – 8 ]…”

Section: Introductionmentioning

confidence: 99%

“…Many repeated pain stimuli will cause stress reactions to the body, leading to a series of short-term and long-term adverse effects on neonates. [6][7][8] Non-drug interventions play an important role in neonatal pain management due to their simplicity and less adverse effects. In the sound environment of the fetus, the mother's voice plays a leading role.…”

Section: Introductionmentioning

confidence: 99%

Maternal voice reduces procedural pain in neonates: A meta-analysis of randomized controlled trials

Jin

Zhang²,

Yang³

et al. 2023

Medicine

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Background: Procedural pain management is a very important part in the clinical care of neonates. We aimed to conduct a meta-analysis to evaluate the effects of maternal voice on neonatal procedural pain, to provide insights to the clinical pain care of neonates. Methods: Two researchers independently searched PubMed, EMBASE, The Cochrane Library, CINAHL, Web of Science, China Biomedical Literature Database, China National Knowledge Infrastructure, Wanfang and Weipu Database for randomized controlled trials (RCTs) involving the effects of maternal voice on the procedural pain of neonates up to October 25, 2022. Two investigators screened the literature based on the inclusion and exclusion criteria and evaluated the methodological quality of the inclusion study. RevMan 5.3 software was used for the meta-analysis. Results: A total of 8 RCTs with a total of 584 neonates were included. Our meta-analysis indicated that maternal voice reduces the pain score (SMD = −0.60, 95% CI: −0.81 to −0.39) and heart rate (SMD = −0.81, 95% CI: −1.44 to −0.18) and increases the comfort level (SMD = −0.47, 95% CI: −0.83 to −0.11) and blood oxygen saturation (SMD = 0.70, 95% CI: 0.03–1.38) during procedure (all P < .05). Moreover, maternal voice reduces the pain score (SMD = −0.58, 95% CI: −0.88 to −0.28) and heart rate (SMD = −0.44, 95% CI: −0.75 to −0.12) and increases the blood oxygen saturation (SMD = 0.41, 95% CI: 0.00 to −0.82) after procedure (all P < .05). No publication biases were detected by the funnel plots and Egger tests (all P > .05). Conclusion: Maternal voice is beneficial to reduce procedural pain and improve the physiological indicators in neonates. It is still necessary to conduct high-quality, large sample studies in the future to further elucidate the effect of maternal voice on neonatal pain care.

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“…Early stress in the neonatal intensive care unit, particularly repetitive noxious manipulation (10,11), has a range of adverse effects on the immediate and long-term brain and behavioral development of both infants and young children, including learning di culties, attention de cits, and poor emotional control (12,13). Animal models have also shown that rats that experience repeated painful pinprick manipulations in the early postnatal period show reduced spatial learning, increased depressive and anxious behavior in later life, and abnormal hippocampal tissue density (14).…”

Section: Introductionmentioning

confidence: 99%

Proteomics of long-term neurodevelopmental disorders of rats exposed to early pain stimulation in the neonatal period

Zuo

et al. 2023

Preprint

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Objective To screen the feasibility and value of quantitative proteomic tandem mass spectrometry labeling (TMT) technology for early pain stimulation leading to neurodevelopmental disorders during puberty in neonatal rats. Methods The rats were randomly divided into two groups at postnatal day one (P1), and the skin was pricked for seven consecutive days in the experimental group; the control group was stroked simultaneously. A Morris water maze experiment was performed at P45 and P48. The rats were sacrificed at P50, and the proteins extracted from the hippocampal tissues were analyzed by TMT quantitative proteomics. The differentially expressed proteins were identified as biologically relevant proteins after pain intervention. Results The Morris water maze experiment suggested that the experimental group of rats had a significantly longer escape latency at P45 and P48 than the control group (P<0.05). At P49, Rats in the experimental group crossed the traversing platform less often than the control group within 60 s. Hippocampal tissue proteomics analysis showed than 33 proteins were upregulated, and 37 were downregulated. The differentially expressed proteins were enriched in different GO subsets, the most significant of which were sucrose metabolic process, response to stilbenoid maltose metabolic process, disaccharide metabolic process, circulating immunoglobulin complex, haptoglobin-hemoglobin complex, hemoglobin complex, replisome, purine-rich negative regulatory element binding, biliverdin reductase activity, alpha-1,4-glucosidase activity, and retinal dehydrogenase activity. KEGG enrichment analysis was most significant for starch and sucrose metabolism, galactose metabolism, antigen processing and presentation, and TGF-beta signaling. The core proteins were identified by constructing protein interaction networks. Four essential differentially expressed proteins were screened, including microtubule-associated serine-/threonine-protein kinase, carbonic anhydrase 3, F-box and leucine-rich repeat protein 4, and NADH-ubiquinone oxidoreductase chain 4L. Conclusions TMT-labeled proteomics identified energy metabolic processes, developmental processes, cellular processes, bioregulation, and signaling as the main targets of distant neurodevelopmental disorders caused by painful stimulation. Microtubule-associated serine/threonine-protein kinase, carbonic anhydrase 3, F-box and leucine-rich repeat protein 4, and NADH-ubiquinone oxidoreductase chain 4L may be involved in the cognitive impairment of adolescence caused by early pain stimulation in neonatal rats.

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The effect of gentle human touch on pain, comfort and physiological parameters in preterm infants during heel lancing

Cited by 8 publications

References 30 publications

Effect of non-pharmacological interventions on pain in preterm infants in the neonatal intensive care unit: a network meta-analysis of randomized controlled trials

Effect of non-pharmacological interventions on pain in preterm infants in the neonatal intensive care unit: a network meta-analysis of randomized controlled trials

Maternal voice reduces procedural pain in neonates: A meta-analysis of randomized controlled trials

Proteomics of long-term neurodevelopmental disorders of rats exposed to early pain stimulation in the neonatal period

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