The Effect of Gentian Violet on the Organism of Blastomycotic Infection

Sanderson, Everett S.; Smith, Dudley C.

doi:10.1001/archderm.1927.02380020025003

Cited by 10 publications

(2 citation statements)

References 5 publications

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“…in a dilution of 1:500,000 (Sanderson and Smith,41) but is of little therapeutic value. Noojin and C a l l a~a y~~ tested seven sulfonamides against B. dermatitidis in nitro and found that sulfonamilamide and sulfadiazine were the most effective.…”

Section: Treatmentmentioning

confidence: 99%

Cryptococcosis and Blastomycosis

Benham

1950

Annals of the New York Academy of Sciences

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Section: Treatmentmentioning

confidence: 99%

Cryptococcosis and Blastomycosis

Benham

1950

Annals of the New York Academy of Sciences

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“…1 Throughout the first half of the twentieth century, gentian violet was widely adopted for use in a variety of diseases including trench mouth, thrush, impetigo, burns, pinworm, and cutaneous and systemic fungal infections. [2][3] Claims of gentian violet efficacy during this time period are difficult to ascertain, given that the composition of gentian violet dyes varied and the authors did not always describe the precise solutions used in their publications. Its use lost popularity with physicians with the discovery and mass manufacture of sulfa medicines and penicillin in the 1940s, and scientific research shifted to the development of novel antibiotic families.…”

Section: Introductionmentioning

confidence: 99%

The Antibacterial Action of Safranin and Gentian Violet

AL-Khikani¹,

Ayit²

2022

Rambam Maimonides Med J

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Background: The increasing resistance of many bacterial pathogens against antibiotic measures urgently requires new or repurposing therapeutic strategies. Gentian violet is a triarylmethane dye used as a histological stain and for Gram’s method of classifying bacteria. It also exerts an antimicrobial effect against certain pathogens, especially dermatological infections. Safranin is the most popular counterstain used in medical laboratories due to its low cost and safe laboratory usage. However, few studies have been conducted on the antimicrobial activity of safranin. Objective: With the growing prevalence of multidrug-resistant bacteria, this study aimed to evaluate the antibacterial efficacy of gentian violet and safranin against multidrug-resistant Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa). Methods: All tested bacteria were multidrug-resistant (MDR) bacteria isolated from skin infections (abscesses and wounds). Using gentian violet and safranin, antibacterial effects were studied using the well-diffusion method against 20 samples of clinically isolated bacteria, 10 diagnosed as S. aureus, and 10 as P. aeruginosa. Bacteria were diagnosed using the VITEK 2 automated system (bioMérieux, Marcy-l’Étoile, France). Iodine served as the control agent, since both Gram-positive and Gram-negative bacteria are sensitive to it. Results: Gentian violet dye has been shown to be 100% sensitive to both Gram-positive and Gram-negative bacterial isolates. Although safranin also had high sensitivity (100%) to S. aureus isolates, its sensitivity to P. aeruginosa was only 20%. Staphylococcus aureus was more resistant to iodine (40% sensitivity) compared to P. aeruginosa, which was 100% sensitive to iodine. Conclusions: Gentian violet and safranin are low-cost and better tolerated topical agents that have potential for use in dermatological applications. Gentian violet had good antibacterial activity against both Gram-positive and Gram-negative bacteria, making it useful for treating bacterial skin pathogens such as S. aureus and P. aeruginosa especially for MDR bacteria. While safranin has good efficacy against Gram-positive bacteria (S. aureus), its effect against Gram-negative bacteria (e.g. P. aeruginosa) is poor.

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The Use of Gentian Violet in Erosio Interdigitalis Saccharomycetica

Cornbleet¹

1929

Arch Dermatol

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The Effect of Gentian Violet on the Organism of Blastomycotic Infection

Cited by 10 publications

References 5 publications

Cryptococcosis and Blastomycosis

Cryptococcosis and Blastomycosis

The Antibacterial Action of Safranin and Gentian Violet

The Use of Gentian Violet in Erosio Interdigitalis Saccharomycetica

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