The effect of GelMA/alginate interpenetrating polymeric network hydrogel on the performance of porous zirconia matrix for bone regeneration applications

Jin, Meiqi; Sun, Na-Bo; Weng, Wenxian; Sang, Zhentao; Liu, Taotao; Xia, Wei; Wang, Shuze; Sun, Xiaoting; Wang, Tianlin; Li, Heran; Yang, Haw

doi:10.1016/j.ijbiomac.2023.124820

Cited by 6 publications

(4 citation statements)

References 66 publications

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“…For example, Osteogenic growth peptide-incorporated GelMA/HAMA hydrogel [121], Strontiumsubstituted hydroxyapatite/Teriparatide-loaded GelMA/double bonded heparin hydrogel [122], Lithium chloride-loaded GelMA/Sodium alginate (SA) hydrogel [123], Silver-doped Hydroxyapatite microspheres loaded in GelMA hydrogel [124], GelMA/dopamine methacrylate-polydopamine hydrogel coating on phthalazinone-based poly (aryl ether nitrile ketone) [125], calcium phosphate cement/GelMA-poly (N-Hydroxyethyl acrylamide) [126]. GelMA/GO [127], GelMA/dendrimer (G3)functionalized nanoceria [128], rBMSCs-loaded GelMA/alginate hydrogel microspheres incorporated with naringin [129], platelet-derived growth factor-BB (PDGF-BB) loaded GelMA/Laponite ® [130], Zirconia-incorporated GelMA/alginate [131], miR-26a-integrated exos/GelMA-Chitosan-methyl methacrylate [132], anti-CXCL9-loaded and OP3-4 incorporated GelMA [133] have shown promising results in BTE.…”

Section: Variousmentioning

confidence: 99%

Unveiling the versatility of gelatin methacryloyl hydrogels: a comprehensive journey into biomedical applications

Pramanik,

Alhomrani,

Alamri

et al. 2024

Biomed. Mater.

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Gelatin methacryloyl (GelMA) hydrogels have gained significant recognition as versatile biomaterials in the biomedical domain. GelMA hydrogels emulate vital characteristics of the innate extracellular matrix (ECM) by integrating cell-adhering and matrix metalloproteinase-responsive peptide motifs. These features enable cellular proliferation and spreading within GelMA-based hydrogel scaffolds. Moreover, GelMA displays flexibility in processing, as it experiences crosslinking when exposed to light irradiation, supporting the development of hydrogels with adjustable mechanical characteristics. The drug delivery landscape has been reshaped by GelMA hydrogels, offering a favorable platform for the controlled and sustained release of therapeutic actives. The tunable physicochemical characteristics of GelMA enable precise modulation of the kinetics of drug release, ensuring optimal therapeutic effectiveness. In tissue engineering, GelMA hydrogels perform an essential role in the design of the scaffold, providing a biomimetic environment conducive to cell adhesion, proliferation, and differentiation. Incorporating GelMA in three-dimensional printing further improves its applicability in drug delivery and developing complicated tissue constructs with spatial precision. Wound healing applications showcase GelMA hydrogels as bioactive dressings, fostering a conducive microenvironment for tissue regeneration. The inherent biocompatibility and tunable mechanical characteristics of GelMA provide its efficiency in the closure of wounds and tissue repair.GelMA hydrogels stand at the forefront of biomedical innovation, offering a versatile platform for addressing diverse challenges in drug delivery, tissue engineering, and wound healing. This review provides a comprehensive overview, fostering an in-depth understanding of GelMA hydrogel’s potential impact on progressing biomedical sciences.

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Section: Variousmentioning

confidence: 99%

Unveiling the versatility of gelatin methacryloyl hydrogels: a comprehensive journey into biomedical applications

Pramanik,

Alhomrani,

Alamri

et al. 2024

Biomed. Mater.

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“… 11 , 44 , 119 It has excellent biocompatibility and enzymatic degradation. 45 Pure GelMA has poor mechanical properties and a relatively rapid degradation rate. 46 Moreover, GelMA exhibits superior printability properties compared to gelatin and other bioinks.…”

Section: Materials Suitable For Healing Osteochondral Defectsmentioning

confidence: 99%

“…Gelatin-methacrylate (GelMA), a derivate of gelatin, possesses a large number of arginine-glycine-aspartic acid sequences that are favorable for cell adhesion, migration and growth. ,, It has excellent biocompatibility and enzymatic degradation . Pure GelMA has poor mechanical properties and a relatively rapid degradation rate .…”

Section: Materials Suitable For Healing Osteochondral Defectsmentioning

confidence: 99%

Materials Suitable for Osteochondral Regeneration

Novotná,

Franková

2024

ACS Omega

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Osteochondral defects affect articular cartilage, calcified cartilage, and subchondral bone. The main problem that they cause is a different behavior of cell tissue in the osteochondral and bone part. Articular cartilage is composed mainly of collagen II, glycosaminoglycan (GAG), and water, and has a low healing ability due to a lack of vascularization. However, bone tissue is composed of collagen I, proteoglycans, and inorganic composites such as hydroxyapatite. Due to the discrepancy between the characters of these two parts, it is difficult to find materials that will meet all the structural and other requirements for effective regeneration. When designing a scaffold for an osteochondral defect, a variety of materials are available, e.g., polymers (synthetic and natural), inorganic particles, and extracellular matrix (ECM) components. All of them require the accurate characterization of the prepared materials and a number of in vitro and in vivo tests before they are applied to patients. Taken in concert, the final material needs to mimic the structural, morphological, chemical, and cellular demands of the native tissue. In this review, we present an overview of the structure and composition of the osteochondral part, especially synthetic materials with additives appropriate for healing osteochondral defects. Finally, we summarize in vitro and in vivo methods suitable for evaluating materials for restoring osteochondral defects.

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“…Owing to the non-degradable properties of ZrO 2 , its scaffold can assist as a permanent implant material, which provides suitable mechanical support for the tissues as well as a host environment for cell infiltration, waste disposal, nutrient transport, new tissue generation, etc. [ 84 ].…”

Section: Biomedical Applications Of Zro 2 Npsmentioning

confidence: 99%

Biomedical Applications of Zirconia-Based Nanomaterials: Challenges and Future Perspectives

Bannunah

2023

Molecules

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ZrO2 nanoparticles have received substantially increased attention in every field of life owing to their wide range of applications. Zirconium oxide is a commercially economical, non-hazardous, and sustainable metal oxide having diversified potential applications. ZrO2 NPs play a vast role in the domain of medicine and pharmacy such as anticancer, antibacterial, and antioxidant agents and tissue engineering owing to their reliable curative biomedical applications. In this review article, we address all of the medical and biomedical applications of ZrO2 NPs prepared through various approaches in a critical way. ZrO2 is a bio-ceramic substance that has received increased attention in biomimetic scaffolds owing to its high mechanical strength, excellent biocompatibility, and high chemical stability. ZrO2 NPs have demonstrated potential anticancer activity against various cancer cells. ZrO2-based nanomaterials have exhibited potential antibacterial activity against various bacterial strains and have also demonstrated excellent antioxidant activity. The ZrO2 nanocomposite also exhibits highly sensitive biosensing activity toward the sensing of glucose and other biological species.

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The effect of GelMA/alginate interpenetrating polymeric network hydrogel on the performance of porous zirconia matrix for bone regeneration applications

Cited by 6 publications

References 66 publications

Unveiling the versatility of gelatin methacryloyl hydrogels: a comprehensive journey into biomedical applications

Unveiling the versatility of gelatin methacryloyl hydrogels: a comprehensive journey into biomedical applications

Materials Suitable for Osteochondral Regeneration

Biomedical Applications of Zirconia-Based Nanomaterials: Challenges and Future Perspectives

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