2005
DOI: 10.1097/00129804-200505000-00007
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The Effect of Furosemide Infusion on Serum Epidermal Growth Factor Concentration After Acute Lung Injury

Abstract: Acute lung injury and its more severe form, acute respiratory distress syndrome, are clinical syndromes of progressive hypoxemia and ventilation-perfusion mismatch with decreasing pulmonary compliance in the absence of congestive heart failure. Epidermal growth factor is involved in the pathogenesis of airway inflammation as well as a proinflammatory effect in other tissues. Furosemide has been shown to improve pulmonary gas exchange and intrapulmonary shunt by a nondiuretic mechanism in animal models of acute… Show more

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Cited by 7 publications
(6 citation statements)
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“…Studies permitting the adjustment of the infusion burden on shock patients in addition to ARDS were excluded. Although a large number of cases were included in the Fluids and Catheters Treatment Trial (FACTT 2006 study),213 the other two studies RCTs214, 215 included only a small number of cases. No significant differences in short‐term mortality were observed, and the number of VFDs within a 28‐day period increased significantly (+2.5 days).…”
Section: Cq10: Management Of the Mechanically Ventilated Patientmentioning
confidence: 99%
“…Studies permitting the adjustment of the infusion burden on shock patients in addition to ARDS were excluded. Although a large number of cases were included in the Fluids and Catheters Treatment Trial (FACTT 2006 study),213 the other two studies RCTs214, 215 included only a small number of cases. No significant differences in short‐term mortality were observed, and the number of VFDs within a 28‐day period increased significantly (+2.5 days).…”
Section: Cq10: Management Of the Mechanically Ventilated Patientmentioning
confidence: 99%
“…Bilateral chest infiltrates on the chest radiograph (CXR) were used in 118/146 (80.8%) RCTs. 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , ...…”
Section: Resultsmentioning
confidence: 99%
“…As a result of a systematic review, three RCTs comparing adult patients with ARDS who underwent fluid restriction with patients who were not fluid restricted were found [127129]. A study that examined the infused fluid volume in patients with shock in addition to patients with ARDS was excluded.…”
Section: Resultsmentioning
confidence: 99%