The Effect of Fucoidan on Cellular Oxidative Stress and the CatD-Bax Signaling Axis in MN9D Cells Damaged by 1-Methyl-4-Phenypyridinium

Liang, Zhigang; Liu, Zhuli; Sun, Xuwen; Tao, Manli; Xiao, Xiao; Yu, Guoping; Wang, Xiaomin

doi:10.3389/fnagi.2018.00429

Cited by 19 publications

(14 citation statements)

References 25 publications

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“…Three fucoidan extracts from Sargassum crassifolium attenuated H 2 O 2 -induced cytotoxicity in rat pheochromocytoma PC-12 cells [ 205 ]. In the MPP + PD model, fucoidan attenuated cytotoxicity in a dopaminergic neuronal precursor cell line (MN9D) [ 183 , 186 ] by protecting lysosomes, reducing the expression of light chain 3-II (LC3-II), inhibiting the expression of cathepsin D (CatD)-Bax and the OS response [ 186 ]. Fucoidan of Sargassum hemiphyllum attenuated 6-hydroxydopamine-induced apoptosis in SH-SY5Y cells [ 206 ].…”

Section: Neuropharmacological Potentials Of Marine Algae and Theirmentioning

confidence: 99%

Neuroprotective Potentials of Marine Algae and Their Bioactive Metabolites: Pharmacological Insights and Therapeutic Advances

et al. 2020

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Beyond their significant contribution to the dietary and industrial supplies, marine algae are considered to be a potential source of some unique metabolites with diverse health benefits. The pharmacological properties, such as antioxidant, anti-inflammatory, cholesterol homeostasis, protein clearance and anti-amyloidogenic potentials of algal metabolites endorse their protective efficacy against oxidative stress, neuroinflammation, mitochondrial dysfunction, and impaired proteostasis which are known to be implicated in the pathophysiology of neurodegenerative disorders and the associated complications after cerebral ischemia and brain injuries. As was evident in various preclinical studies, algal compounds conferred neuroprotection against a wide range of neurotoxic stressors, such as oxygen/glucose deprivation, hydrogen peroxide, glutamate, amyloid β, or 1-methyl-4-phenylpyridinium (MPP+) and, therefore, hold therapeutic promise for brain disorders. While a significant number of algal compounds with promising neuroprotective capacity have been identified over the last decades, a few of them have had access to clinical trials. However, the recent approval of an algal oligosaccharide, sodium oligomannate, for the treatment of Alzheimer’s disease enlightened the future of marine algae-based drug discovery. In this review, we briefly outline the pathophysiology of neurodegenerative diseases and brain injuries for identifying the targets of pharmacological intervention, and then review the literature on the neuroprotective potentials of algal compounds along with the underlying pharmacological mechanism, and present an appraisal on the recent therapeutic advances. We also propose a rational strategy to facilitate algal metabolites-based drug development.

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Section: Neuropharmacological Potentials Of Marine Algae and Theirmentioning

confidence: 99%

Neuroprotective Potentials of Marine Algae and Their Bioactive Metabolites: Pharmacological Insights and Therapeutic Advances

et al. 2020

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“…Various models of Parkinson’s disease treated with fucoidans have shown encouraging data [95,96]. While the mechanism behind these results is unclear, the recent findings on microbiome connections with Parkinson’s disease and many other neurological conditions point to a potential effect on gut microbiota [97].…”

Section: Neuroprotectionmentioning

confidence: 99%

Therapies from Fucoidan: New Developments

Fitton¹,

Stringer²,

Park³

et al. 2019

Marine Drugs

129

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Since our last review in 2015, the study and use of fucoidan has extended in several research areas. Clinical use of fucoidan for the treatment of renal disease has become available and human safety studies have been undertaken on radiolabeled fucoidan for the purpose of imaging thrombi. Fucoidan has been incorporated into an increasing number of commercially available supplements and topical treatments. In addition, new measuring techniques are now available to assess the biologically relevant uptake of fucoidans and to assist in production. Microbiome modulation and anti-pathogenic effects are increasingly promising applications for fucoidans, due to the need for alternative approaches to antibiotic use in the food chain. This review outlines promising new developments in fucoidan research, including potential future therapeutic use.

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“…Newer reports about the molecular pathways involved in fucoidan neuroprotective effects on dopaminergic nerve precursor cells (MN9D) treated with 1-methyl-4-phenyl pyridine (MPP + ) suggest its involvement in increasing superoxide dismutase (SOD) activity and reduced glutathione (GSH) concentration and decreasing the apoptosis levels by downregulation of Bax expression [13].…”

Section: Fucoidan and Neurodegenerationmentioning

confidence: 99%

“…The above characteristics and effects are described in further detail in this review in correlation with pre-clinical and translation research for treatment of mental disorders, and brain damage due to disease and injury. Indeed, there is substantial evidence regarding its protective and beneficial actions in the central nervous system (CNS), both at whole organ and cellular levels, which is a plausible starting point for developing novel therapies for severe neurodegenerative and neurocognitive disorders such as Alzheimer Disease (AD), Parkinson Disease (PD), and others [13,14]. Furthermore, another line of research confirmed the beneficial influence of fucoidan in preserving cellular integrity and inhibition of fibrosis in drug-induced liver injury and hepatocellular carcinoma [15,16].…”

Section: Introductionmentioning

confidence: 99%

Potential Beneficial Actions of Fucoidan in Brain and Liver Injury, Disease, and Intoxication—Potential Implication of Sirtuins

2020

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Increased interest in natural antioxidants has brought to light the fucoidans (sulfated polysaccharides present in brown marine algae) as highly valued nutrients as well as effective and safe therapeutics against several diseases. Based on their satisfactory in vitro antioxidant potency, researchers have identified this molecule as an efficient remedy for neuropathological as well as metabolic disorders. Some of this therapeutic activity is accomplished by upregulation of cytoprotective molecular pathways capable of restoring the enzymatic antioxidant activity and normal mitochondrial functions. Sirtuin-3 has been discovered as a key player for achieving the neuroprotective role of fucoidan by managing these pathways, whose ultimate goal is retrieving the entirety of the antioxidant response and preventing apoptosis of neurons, thereby averting neurodegeneration and brain injuries. Another pathway whereby fucoidan exerts neuroprotective capabilities is by interactions with P-selectin on endothelial cells, thereby preventing macrophages from entering the brain proper. Furthermore, beneficial influences of fucoidan have been established in hepatocytes after xenobiotic induced liver injury by decreasing transaminase leakage and autophagy as well as obtaining optimal levels of intracellular fiber, which ultimately prevents fibrosis. The hepatoprotective role of this marine polysaccharide also includes a sirtuin, namely sirtuin-1 overexpression, which alleviates obesity and insulin resistance through suppression of hyperglycemia, reducing inflammation and stimulation of enzymatic antioxidant response. While fucoidan is very effective in animal models for brain injury and neuronal degeneration, in general, it is accepted that fucoidan shows somewhat limited potency in liver. Thus far, it has been used in large doses for treatment of acute liver injuries. Thus, it appears that further optimization of fucoidan derivatives may establish enhanced versatility for treatments of various disorders, in addition to brain injury and disease.

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The Effect of Fucoidan on Cellular Oxidative Stress and the CatD-Bax Signaling Axis in MN9D Cells Damaged by 1-Methyl-4-Phenypyridinium

Cited by 19 publications

References 25 publications

Neuroprotective Potentials of Marine Algae and Their Bioactive Metabolites: Pharmacological Insights and Therapeutic Advances

Neuroprotective Potentials of Marine Algae and Their Bioactive Metabolites: Pharmacological Insights and Therapeutic Advances

Therapies from Fucoidan: New Developments

Potential Beneficial Actions of Fucoidan in Brain and Liver Injury, Disease, and Intoxication—Potential Implication of Sirtuins

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