The Effect of Food on the Pharmacokinetics of Multiple-Dose Terbinafine in Young and Elderly Healthy Subjects

Terbinafine pharmacokinetics after single dose oral administration in the dog

“…Results of this study show that oral terbinafine is rapidly absorbed when given with food, reaching T max within approximately 3.5 h. This is slightly longer than the T max described in humans (2 h) after oral administration of a single dose of terbinafine 34 . In our study, terbinafine was administered with a meal because studies in humans have found that higher C max is achieved when terbinafine is taken with food compared with on an empty stomach 21 …”

Physiologically Based Pharmacokinetic Model for Terbinafine in Rats and Humans

“…The terbinafine distribution in human skin tissue and plasma following oral administration of 250 mg of terbinafine for 14 days was accurately predicted during the course of treatment by use of PB-PK model II data scaled up from data from rats (with repeated oral dosing taken into consideration). A comparison of published concentration-time data for humans following administration of 250 mg of terbinafine for 14 days (13,32) and the simulated concentration data is presented in Fig. 6.…”

Single-dose pharmacokinetics of orally administered terbinafine in bearded dragons (Pogona vitticeps) and the antifungal susceptibility patterns of Nannizziopsis guarroi

“…For the bearded dragons of the present study, terbinafine was administered with a meal because administration of terbinafine with food enhances the absorption and increases the C max for the drug in human patients. 32 The inclusion of a gavage-fed meal with the terbinafine was added to the methods of the full study to facilitate peak absorption. The C max (434 ± 338 ng/mL) for the bearded dragons of the present study following oral administration of terbinafine at a dose of 20 mg/kg was similar to the C max for African penguins receiving terbinafine a dose of 15 mg/kg, PO (200 ng/mL) 21 ; horses receiving terbinafine at a dose of 20 mg/kg, PO (310 ng/mL) 31 ; and Hispaniolan Amazon parrots receiving terbinafine at a dose of 60 mg/kg, PO (353 ng/mL), 19 but much lower than the C max measured in red-tailed hawks (1,200 ng/ mL), 23 cats (3,220 ng/mL), 30 and Greyhound dogs 31 (4,010 ng/mL) that received terbinafine at a dose of 30 mg/kg, PO.…”