The effect of food on the pharmacokinetics of oral fluralaner in dogs

Walther, Feli M; Allan, Mark J; Roepke, Rainer K. A.; Nuernberger, Martin C

doi:10.1186/1756-3305-7-84

Cited by 46 publications

(44 citation statements)

References 6 publications

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“…Fluralaner (4‐[5‐(3,5‐dichlorophenyl)‐4,5‐dihydro‐5‐(trifluoromethyl)‐3‐isoxazolyl]‐2‐methyl‐N‐[2‐oxo‐2‐[(2,2,2‐trifluoroethyl)amino]ethyl]‐benzamide) is a rapidly absorbed isoxazoline, that reaches maximum concentrations within 24 h and is quantifiable in plasma for up to 112 days after a single oral administration . Absorption is increased when fluralaner is given with food; it is predominantly excreted unchanged in the faeces by hepatic elimination . It is administered orally every three months.…”

Section: Treatmentmentioning

confidence: 99%

Diagnosis and treatment of demodicosis in dogs and cats

Mueller¹,

Rosenkrantz²,

Bensignor³

et al. 2020

Veterinary Dermatology

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Background Demodicosis is a common disease in small animal veterinary practice worldwide with a variety of diagnostic and therapeutic options. Objectives To provide consensus recommendations on the diagnosis, prevention and treatment of demodicosis in dogs and cats. Methods and materials The authors served as a Guideline Panel (GP) and reviewed the literature available before December 2018. The GP prepared a detailed literature review and made recommendations on selected topics. A draft of the document was presented at the North American Veterinary Dermatology Forum in Maui, HI, USA (May 2018) and at the European Veterinary Dermatology Congress in Dubrovnik, Croatia (September 2018) and was made available via the World Wide Web to the member organizations of the World Association for Veterinary Dermatology for a period of three months. Comments were solicited and responses were incorporated into the final document. Conclusions In young dogs with generalized demodicosis, genetic and immunological factors seem to play a role in the pathogenesis and affected dogs should not be bred. In old dogs and cats, underlying immunosuppressive conditions contributing to demodicosis should be explored. Deep skin scrapings are the diagnostic gold standard for demodicosis, but trichograms and tape squeeze preparations may also be useful under certain circumstances. Amitraz, macrocyclic lactones and more recently isoxazolines have all demonstrated good efficacy in the treatment of canine demodicosis. Therapeutic selection should be guided by local drug legislation, drug availability and individual case parameters. Evidence for successful treatment of feline demodicosis is strongest for lime sulfur dips and amitraz baths.

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Section: Treatmentmentioning

confidence: 99%

Diagnosis and treatment of demodicosis in dogs and cats

Mueller¹,

Rosenkrantz²,

Bensignor³

et al. 2020

Veterinary Dermatology

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“…Following oral administration to dogs with or without food, fluralaner is rapidly absorbed, and provides 100% effectiveness against fleas and ticks ( Ixodes ricinus ) within 1 day after treatment [6, 7]. Blood levels are then sustained and provide flea and tick effectiveness >95% for up to 12 weeks [6, 7].…”

Section: Introductionmentioning

confidence: 99%

A randomized, blinded, controlled USA field study to assess the use of fluralaner tablets in controlling canine flea infestations

Meadows¹,

Guerino²,

Sun³

2014

Parasites & Vectors

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BackgroundThe novel isoxazoline molecule fluralaner provides 12 weeks activity against fleas and 8 to 12 weeks against tick infestations according to label claims.MethodsThis blinded, multi-center study in client-owned dogs evaluated the flea control provided by a single oral fluralaner treatment (25–56 mg/kg; Bravecto™, Merck Animal Health) compared to a control group administered three oral spinosad (30 – 60 mg/kg; Comfortis®, Elanco) treatments at 4-week intervals together with an amitraz collar (9%, Preventic®, Virbac). Households were randomized (3:1 ratio) to either fluralaner (224 dogs, 118 households) or control (70 dogs, 39 households). Within households, one primary dog with at least 10 live fleas at enrollment was randomly selected for whole body flea counts every 4 weeks through Week 12; all dogs were followed for safety until Week 12. Fluralaner dogs received two additional doses at Weeks 12 and 24 for further safety and palatability observations through Week 26.ResultsGeometric mean flea count reductions from baseline for the fluralaner group at Weeks 4, 8, and 12 were 99.7%, 99.8%, and 99.8%, respectively; and 96.1%, 99.5%, and 99.6% for the spinosad controls. Percentages of flea-free primary dogs at Weeks 4, 8, and 12 were 91.1%, 95.4%, and 95.3% for the fluralaner group; and 44.7%, 88.2%, and 84.4% for the controls; the differences were significant at Weeks 4 (P < 0.0001) and 12 (P = 0.0370). Improvements in veterinarian assessed flea allergy dermatitis (FAD) were observed in both groups. Fluralaner tablets were accepted free choice in over 90% of doses. The most common adverse event was vomiting, occurring in 7.1% of the fluralaner group and 14.3% of the controls. No treatment related serious adverse events were reported.ConclusionsA single treatment of dogs with the palatable fluralaner flavored chewable tablet provides a safe and effective option for 12 weeks of flea control at least equivalent to that of 3 sequential treatments with spinosad tablets. Linked to the high level of flea control was a substantial alleviation of associated signs of FAD.

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“…Fluralaner formulated as a flavoured chewable tablet is commercially available for immediate and persistent killing of ticks and fleas on dogs over 12 weeks, eliciting its primary action through feeding activity [7]. In a field trial, a single dose of fluralaner provided 12 weeks activity against fleas in dogs [8], and it was shown to be safe and well tolerated [8,9].…”

Section: Introductionmentioning

confidence: 99%