The effect of female body mass index on in vitro fertilization cycle outcomes: a multi-center analysis

Kudesia, Rashmi; Wu, Hongyu; Cohn, K. Hunter; Tan, Lei; Lee, Joseph A.; Copperman, A.B.; Beim, P. Yurttas

doi:10.1007/s10815-018-1290-6

Cited by 50 publications

(43 citation statements)

References 46 publications

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“…The impact of obesity on pregnancy rates is a controversial topic in the literature. A recent large multi-center retrospective analysis including 51,198 women in their first autologous IVF cycle reported an overall negative impact of high BMI on ongoing pregnancy rate [15]. Another large retrospective study assessing the outcome of 9587 oocytes donated by normoweight donors and transferred to women with different BMI reported decreased implantation, pregnancy, and live birth rates associated with higher BMI, suggesting that maternal obesity may also compromise uterine receptivity [51].…”

Section: Discussionmentioning

confidence: 99%

“…Nowadays, obese women failing to conceive naturally have access to assisted reproduction techniques (ARTs), but the literature is not clear regarding whether their outcomes might be compromised. While some studies suggest no direct negative impact [9,10], but instead possibly decreased overall outcomes due to a higher percentage of poor responders in the obese population [11], others have provided evidence that obesity is associated with lower implantation, pregnancy, and live birth rates [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

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Maternal body mass index affects embryo morphokinetics: a time-lapse study

Bartolacci

Buratini

Moutier

et al. 2019

J Assist Reprod Genet

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Purpose To assess the effect of body mass index (BMI) on morphokinetic parameters of human embryos evaluated with timelapse technology during in vitro culture. Methods A retrospective analysis of ART cycles utilizing time-lapse technology was undertaken to assess the potential impact of maternal BMI on morphokinetic and static morphological parameters of embryo development. The cohort of patients was divided into four groups: 593 embryos from 128 underweight women in group A; 5248 embryos from 1107 normal weight women in group B; 1053 embryos from 226 overweight women in group C; and 286 embryos from 67 obese women in group D. Results After adjusting for maternal age, paternal age, and cause of infertility, time to reach five blastomeres (t5) and time to reach eight blastomeres (t8) were longer in obese women compared with normoweight women [50.84 h (46.31-55.29) vs. 49.24 h (45.69-53.22) and 57.89 h (51.60-65.94) vs. 55.66 h (50.89-62.89), adjusted p < 0.05 and adjusted p < 0.01, respectively]. In addition, t8 was also delayed in overweight compared with normoweight women [56.72 h (51.83-63.92) vs. 55.66 h (50.89-62.89), adjusted p < 0.01]. No significant differences were observed among groups with regard to embryo morphology and pregnancy rate. Miscarriage rate was higher in underweight compared with normoweight women (OR = 2.1; 95% CI 1.12-3.95, adjusted p < 0.05). Conclusion Assessment with time-lapse technology but not by classical static morphology evidences that maternal BMI affects embryo development. Maternal obesity and overweight are associated with slower embryo development.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Maternal body mass index affects embryo morphokinetics: a time-lapse study

Bartolacci

Buratini

Moutier

et al. 2019

J Assist Reprod Genet

View full text Add to dashboard Cite

show abstract

“…It appears that poor responders may include patients entailing numerous striking differences in profiling. Factors such as genetic polymorphisms or obesity may serve as leading factors for poor ovarian response at all ages [ 136 , 137 , 138 ]. On the other hand, women of advanced age driven by socioeconomic or other issues to delay parenthood, may face diminished ovarian response as well.…”

Section: Discussionmentioning

confidence: 99%

The Conundrum of Poor Ovarian Response: From Diagnosis to Treatment

et al. 2020

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Despite recent striking advances in assisted reproductive technology (ART), poor ovarian response (POR) diagnosis and treatment is still considered challenging. Poor responders constitute a heterogeneous cohort with the common denominator of under-responding to controlled ovarian stimulation. Inevitably, respective success rates are significantly compromised. As POR pathophysiology entails the elusive factor of compromised ovarian function, both diagnosis and management fuel an ongoing heated debate depicted in the literature. From the criteria employed for diagnosis to the plethora of strategies and adjuvant therapies proposed, the conundrum of POR still puzzles the practitioner. What is more, novel treatment approaches from stem cell therapy and platelet-rich plasma intra-ovarian infusion to mitochondrial replacement therapy have emerged, albeit not claiming clinical routine status yet. The complex and time sensitive nature of this subgroup of infertile patients indicates the demand for a consensus on a horizontally accepted definition, diagnosis and subsequent effective treating strategy. This critical review analyzes the standing criteria employed in order to diagnose and aptly categorize POR patients, while it proceeds to critically evaluate current and novel strategies regarding their management. Discrepancies in diagnosis and respective implications are discussed, while the existing diversity in management options highlights the need for individualized management.

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“…We read with interest the study by Kudesia et al [1], who aimed to retrospectively explore the impact of female body mass index (BMI) on IVF cycle outcomes. BMI above the normal range was found to be an independent negative prognostic factor for multiple outcomes, including cycle cancelation, oocyte and embryo counts, and ongoing clinical pregnancy.…”

Section: To the Editormentioning

confidence: 99%