The effect of extracts of Irvingia gabonensis (IGOB131) and Dichrostachys glomerata (Dyglomera™) on body weight and lipid parameters of healthy overweight participants

Abstract

Background: Previous work reported the benefits of extracts of 2 Cameroonian spices – Irvingia gabonensis and Dichrostachys glomerata— on obese people with metabolic syndrome. Considering the physio-metabolic changes that accompany obesity, the present study investigates the effects of these extracts on healthy overweight participants over an 8-week test period.Methods: The study was an 8 week randomized double-blind, placebo controlled design involving 48 overweight (BMI 26 – 30) participants (27 females and 19 males), divided into 3 groups – placebo, 300 mg I. gabonensis extract (IGOB131), or 300 mg D. glomerata extract (DyglomeraTM). Capsules containing the placebo or the test formulations were administered once daily before the main meal of the day. No major dietary changes or changes in physical activity were demonstrated during the study. Weight and blood lipid parameters were measured at baseline, and at the 4 and 8 weeks interval.Results: Compared to the placebo group, there were significant (p<0.05) reductions in weight of participants in both test groups over the 8 week period. However, these significant changes were not observed in the initial 4 weeks, even though the lipid parameters in the test groups changed significantly (p<0.05).Conclusion: The extracts of Irvingia gabonensis and Dichrostachys glomerata, at a dose of 300 mg per day, were effective in reducing weight and positively modifying lipid parameters in healthy overweight participants.Keywords: Overweight, Dichrostachys, Irvingia, waist-hip circumference, blood lipids.

The Effects of Irvingia gabonensis Seed Extract Supplementation on Anthropometric and Cardiovascular Outcomes: A Systematic Review and Meta-Analysis

“…One additional article was identified by the manual search. Then, we conducted full-text screening of 11 articles and finally included 5 RCT studies (8,18,(21)(22)(23). The process of the literature search and paper selection is summarized in Figure 1.…”

“…The ROB assessments for individual studies are presented in Table 2. Two out of the five included RCTs were commercially funded (22,23), while one RCT was supported by an academic institution (21). The remaining two RCTs did not report the source of funding (8,18).…”

“…Four RCTs were conducted in Cameroon (2 RCTs were from the same group of investigators) with adults who were overweight or obese (8,(21)(22)(23). All four RCTs were rated as having a high ROB.…”

“…The daily doses of Irvingia gabonensis seed extracts ranged from 300 mg to 1,050 mg. The participants in four studies were overweight or obese (8,(21)(22)(23) and those in one study had metabolic syndrome (18). The control groups received either oat bran, maltodextrin, calcined magnesia, or placebo capsules without detailed information on the formulation.…”

“…The control groups received either oat bran, maltodextrin, calcined magnesia, or placebo capsules without detailed information on the formulation. The types of anthropometric measurements included the following: (18); and (6) hip circumference in two studies (8,21). The results were synthesized and reported outcome-by-outcome as follows.…”