The effect of endometriosis, its stage and activity, and of autoantibodies on in vitro fertilization and embryo transfer success rates

Dmowski, W. Paul; Rana, Nasir; Michalowska, Janina; Friberg, Jan; Papierniak, Cynthia K.; El-Roeiy, Albert

doi:10.1016/s0015-0282(16)57425-1

Cited by 145 publications

(5 citation statements)

References 19 publications

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“…We show that there is a diversity of AAbs in women with endometriosis, with the results obtained herein confirming earlier studies on the patient’s PF that recognize the same set of antigens, including AHSG and histones. 46% of them have five or more AAbs, consistent with the observation that a proportion of EM+ patients, and not all, have an autoimmune component 58,59 , which has led to a mix of correlation of AAbs between the severity of endometriosis and AAbs 60–63 .…”

Section: Discussionsupporting

confidence: 82%

Peritoneal autoantibody landscape in endometriosis

Harden

Tan

et al. 2022

Preprint

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Women with endometriosis have a profound association with autoimmunity. An excess of autoantigens in the peritoneal cavity resulting from retrograde menstruation could lead to inflammation and pathologic autoimmunity. Using a native-conformation protein array, proteome-wide analysis of autoantibodies (AAbs) against 1623 proteins were profiled in peritoneal fluids (PF) of 25 women with endometriosis and 25 endometriosis-negative women. 46% of endometriotic women have five or more AAbs. Diverse cognate autoantigens were identified and corresponding AAbs against proteins involved in implantation, B-cell activation/development, and aberrant migration and mitogenicity. AAbs recognizing tumour suppressor protein p53 were the most frequent at 35% and were targeted against native and citrullinated p53 forms. Further, unsupervised hierarchical clustering and integrative pathway analysis, we observed clusters of endometriosis-associated infertile women with 60% positive for two or more AAbs which are involved in PDGF, TGF-β, RAC1/PAK1/p38/MMP2 signaling, LAT2/NTAL/LAB-mediated calcium mobilisation and integrin-mediated cell adhesion. Together, our data identifies peritoneal autoimmunity in a significant subset of women with endometriosis, with diverse impact on infertility and disease pathophysiology.

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Section: Discussionsupporting

confidence: 82%

Peritoneal autoantibody landscape in endometriosis

Harden

Tan

et al. 2022

Preprint

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“…We have been able to demonstrate that a reduction in abnormal autoantibody levels in women with endometriosis appears to improve fecundity (El Roeiy et al, 1988). A similar observation has been reported in IVF patients (Dmowski et al, 1995). Lastly, while traditional textbooks do not associate classical autoimmune diseases with infertility, a recent study of women with rheumatoid arthritis does exactly that (Lee Nelson et al, 1993).…”

Section: Unexplained Infertility and Endometriosissupporting

confidence: 77%

Autoantibodies in infertility: current opinion

Gleicher

1998

Human Reproduction Update

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“…[ 53 ] Moreover, several studies found deposits of autoantibodies in the eutopic endometrium of endometriosis patients with infertility, [ 55 ] suggesting that autoimmune responses provoked by the regurgitated endometrium may, in turn, impair the fecundity of the eutopic endometrium. Notably, the decreased pregnancy rate of autoantibody-positive patients could be restored with the administration of corticosteroids, [ 56 ] providing a novel therapeutic approach to overcome autoantibody-induced infertility.…”

Section: Adaptive Immunitymentioning

confidence: 99%

“…Corticosteroids are well recognized as autoantibody-suppressive immunomodulators and are extensively utilized in the treatment of autoimmune diseases. Dmowski et al [ 56 ] and Kim et al [ 84 ] reported that autoantibodies negatively affected the pregnancy rates of endometriosis patients undergoing in vitro fertilization (IVF) and that this adverse impact could be reversed with the application of corticosteroids, providing a novel therapeutic strategy to overcome endometriosis-associated infertility. However, the exact mechanisms by which these autoantibodies are produced and how they react with the reproductive system remain unclear and thus require further investigation.…”

Section: Immunological Factors Involved In the Endometriosis Symptomo...mentioning

confidence: 99%

Understanding endometriosis from an immunomicroenvironmental perspective

Fan

Wang

Shi

et al. 2023

Chinese Medical Journal

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Endometriosis, a heterogeneous, inflammatory, and estrogen-dependent gynecological disease defined by the presence and growth of endometrial tissues outside the lining of the uterus, affects approximately 5–10% of reproductive-age women, causing chronic pelvic pain and reduced fertility. Although the etiology of endometriosis is still elusive, emerging evidence supports the idea that immune dysregulation can promote the survival and growth of retrograde endometrial debris. Peritoneal macrophages and natural killer (NK) cells exhibit deficient cytotoxicity in the endometriotic microenvironment, leading to inefficient eradication of refluxed endometrial fragments. In addition, the imbalance of T-cell subtypes results in aberrant cytokine production and chronic inflammation, which contribute to endometriosis development. Although it remains uncertain whether immune dysregulation represents an initial cause or merely a secondary enhancer of endometriosis, therapies targeting altered immune pathways exhibit satisfactory effects in preventing disease onset and progression. Here, we summarize the phenotypic and functional alterations of immune cells in the endometriotic microenvironment, focusing on their interactions with microbiota and endocrine and nervous systems, and how these interactions contribute to the etiology and symptomology of endometriosis.

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The effect of endometriosis, its stage and activity, and of autoantibodies on in vitro fertilization and embryo transfer success rates

Cited by 145 publications

References 19 publications

Peritoneal autoantibody landscape in endometriosis

Peritoneal autoantibody landscape in endometriosis

Autoantibodies in infertility: current opinion

Understanding endometriosis from an immunomicroenvironmental perspective

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