1983
DOI: 10.1055/s-2007-1022022 View full text |Buy / Rent full text
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Abstract: Seventy consecutive patients who had undergone coronary artery bypass surgery were postoperatively treated with either dipyridamole or warfarin for 6 months. The dipyridamole series consisted of 28 patients given 150 mg dipyridamole 3 times daily and the warfarin series, of 42 patients who received the appropriate daily dose of warfarin needed to maintain the prothrombin time within the therapeutic range. The majority of patients in both series belonged to the NYHA class III. Sixty-one percent of the patients … Show more

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“…-This complication, whether it occurs early from thrombosis or later from progressive subintimal proliferation,45 is believed to result from perioperative endothelial damage followed by deposition of platelets on to the subendothelial tissues,6 and, in the experimental animal,Aits occurrence can be limited by treatment with the combination of aspirin and dipyridamole.78 Moreover, this combination has been shown to decrease lipid accumulation in the intima of vein grafts implanted into the arterial circulation of both normolipaemic and hyperlipaemic Requests for reprints to Dr N Brooks, Regional Cardiothoracic Centre, Wythenshawe Hospital, Southmoor Road, Manchester M23 9LT. Accepted for publication 9 October 1984 monkeys.9 Several clinical trials of platelet inhibitor and anticoagulant treatment have been reported,'I- 19 but the findings have been conflicting and in many instances do not withstand critical scrutiny. 20 We report a randomised placebo controlled trial in which we assessed the effect of the combination of aspirin and dipyridamole on coronary vein graft patency one year after operation.…”
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“…-This complication, whether it occurs early from thrombosis or later from progressive subintimal proliferation,45 is believed to result from perioperative endothelial damage followed by deposition of platelets on to the subendothelial tissues,6 and, in the experimental animal,Aits occurrence can be limited by treatment with the combination of aspirin and dipyridamole.78 Moreover, this combination has been shown to decrease lipid accumulation in the intima of vein grafts implanted into the arterial circulation of both normolipaemic and hyperlipaemic Requests for reprints to Dr N Brooks, Regional Cardiothoracic Centre, Wythenshawe Hospital, Southmoor Road, Manchester M23 9LT. Accepted for publication 9 October 1984 monkeys.9 Several clinical trials of platelet inhibitor and anticoagulant treatment have been reported,'I- 19 but the findings have been conflicting and in many instances do not withstand critical scrutiny. 20 We report a randomised placebo controlled trial in which we assessed the effect of the combination of aspirin and dipyridamole on coronary vein graft patency one year after operation.…”
mentioning