The effect of different intraabdominal pressures on lipid peroxidation and protein oxidation status during laparoscopic cholecystectomy

Polat, Coşkun; Yılmaz, Sezgin; Serteser, Mustafa; Köken, Tülay; Kahraman, Ahmet; Dılek, Osman Nuri

doi:10.1007/s00464-002-9258-z

Cited by 74 publications

(63 citation statements)

References 17 publications

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“…In their study on rats, Yilmaz et al [42] did not demonstrate any statistical significance in oxidative stress parameters at both low and high intraabdominal pressures. Polat et al [43] confirmed these results in their study with human subjects. A recent study conducted by Biler et al [44] clearly demonstrated that the ischemic preconditioning method should be used to reduce IRIs, rather than other low-pressure models.…”

Section: Iri Secondary To Laparoscopic/robotic Pneumoperitoneummentioning

confidence: 53%

Robotic and laparoscopic urologic surgery ischemic preconditioning

Zor¹,

Ozgok-Kangal²

2018

MIS

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Laparoscopic and robotic assisted surgeries have evolved from a limited surgical procedure to a major surgical technique during the last three decades. The indications increased incrementally. Despite its several advantages, it has some surgery and pneumoperitoneum related adverse effects and hemodynamic complications. One of them is the ischemia reperfusion injury (IRI) of the abdominal organs that can be developed secondary to pneumoperitoneum. IRI is also a risk factor for acute kidney injury in partial nephrectomy surgeries even performed via open, or laparoscopic/ robotic assisted. To reduce or avoid the IRI related complications during laparoscopy and robotics, several alternative approaches were suggested including ischemic preconditioning (IPC). IPC is a phenomenon that promotes tissue tolerance to ischemia. Since it was first introduced, several studies evaluating its protective effects or mechanism of action have been published. Majority of them demonstrated its potent beneficial effects against IRI. Despite these favorable results, IPC has not yet been used in clinical settings routinely. The unknown parts of the exact mechanisms, the lack of standard protocols for its use such as the duration of clamping, the number of clamping cycles, using an early window or a late window, using local IP or remote IP, and the all remaining uncertainly about these aspects of the process might lead clinicians to be hesitant about its clinical use. In this study we discussed what we have in our hands regarding the effects of IRI and protective mechanisms of IPC, animal studies and clinical evidence of IPC, remote and local IPC, laparoscopy/robotics induced IRI, and role of laparoscopic/robotic IPC.

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Section: Iri Secondary To Laparoscopic/robotic Pneumoperitoneummentioning

confidence: 53%

Robotic and laparoscopic urologic surgery ischemic preconditioning

Zor¹,

Ozgok-Kangal²

2018

MIS

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“…Their study revealed higher transaminase values for the 14 mm Hg group, while the gasless group and 10 mm Hg group displayed almost the same values. Yılmaz et al [25] reported statistically different values of oxidative stress responses for 10 mm Hg and 15 mm Hg groups in a rat model; and Polat et al [13] validated these results in their study with human subjects. Moreover, Guven and et al [27] reported that pneumoperitoneum, even at normal IAP levels, leads to significant oxidativestress-induced biochemical and histologic damage to the ovaries.…”

Section: Discussionmentioning

confidence: 84%

“…An IAP over 20 mm Hg is an emergency situation, called abdominal compartment syndrome. Intraabdominal organ oxidative stress injuries occur due to changes in systemic circulation and the direct effects of IAP on abdominal vessels [13]. There is usually a physiological interval when reactive oxygen radicals and inflammatory cytokines overlay the tissue after surgical trauma, until the organism succesfully eradicates them via multiple signalling cascades.…”

Section: Discussionmentioning

confidence: 99%

“…PN leads to a 10-80% reduction in the rate of blood flow to the intraabominal organs, but it has been reported to return to the normal range after desufflation [10]. In terms of the hypoperfusion and subsequent reperfusion periods, both clinical and experimental studies show that laparoscopic procedures result in a typical model of ischemia and reperfusion (I/R) injury in the organs [11][12][13]. After desufflation, visceral perfusion returns to normal, but oxidative stress remains in the tissues.…”

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confidence: 99%

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The Effects of Different Intraabdominal Pressure Protocols in Laparoscopic Procedures on Oxidative Stress Markers and Morphology in Rat Ovaries

Biler¹,

Yücebilgin²,

Şendağ³

et al. 2014

Adv Clin Exp Med

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Background. To determine the effects of different intraabdominal pressure (IAP) on the ovaries in a laparoscopic rat model. Objectives. The aim of the study was to determine the effects on the ovaries of different intraabdominal pressures (IAP) in laparoscopic surgery in a rat model. Material and Methods. Thirty-two post-pubertal nonpregnant Sprague-Dawley rats were divided randomly into four groups. In the control group, no intraabdominal pressure (IAP) was applied. In Group Pp10 and Group Pp15, an IAP of 10 and 15 mm Hg, respectively, were applied by carbon dioxide insufflation for 60 min, and a 30-min desufflation was carried out. In Group IPp15, a 15 mm Hg IAP was applied for 10 min, and then CO 2 was desufflated for 10 min. After this ischemic preconditioning, IAP was established at 15 mm Hg for 60 min, after which CO 2 was desufflated for 30 min. Erythrocyte and ovarian tissue malondialdehyde (MDA) and histopathologic damage scores were evaluated. Results. In Groups Pp10 and Pp15, ovarian tissue MDA values were significantly increased compared to the control group. In Groups Pp10 and Pp15, erythrocyte MDA values were significantly increased when compared to Group IPp15 and the control group. Ovarian histopatological assesment scores were significantly higher in Group Pp15 than in Groups Pp10 and IPp15. Conclusions. Pneumoperitoneum causes injuries to abdominal organ such as the ovaries. The ischemic preconditioning method is more effective in reducing oxidative stress due to laparoscopic pneumoperitoneum than lowpressure pneumoperitoneum methods (Adv Clin Exp Med 2014, 23, 6, 885-892).

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“…As cirurgias aórticas laparoscópicas tiveram resultados similares ou melhores do que os obtidos com a cirurgia aberta convencional quando comparados os parâme-tros hemodinâmicos, metabólicos e inflamatórios [17][18][19][20][21] e o seguimento em longo prazo 1,3,22 .…”

Section: Introductionunclassified

Curva de aprendizado em cirurgia aórtica videolaparoscópica: estudo experimental em porcos

Yoshida

Rollo

et al. 2008

J. vasc. bras.

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ResumoContexto: A cirurgia videolaparoscópica (CVL) vem evoluindo como alternativa cirúrgica menos invasiva para o tratamento da doença aterosclerótica oclusiva aorto-ilíaca e do aneurisma da aorta abdominal. Poucos estudos avaliaram objetivamente a curva de aprendizado com essa técnica em cirurgia vascular.Objetivo: Avaliar objetivamente os tempos e a evolução de cada passo cirúrgico e demonstrar a exeqüibilidade dessa técnica. Métodos:Entre outubro 2007 e janeiro de 2008, dois cirurgiões vasculares iniciantes na CVL operaram, após cursos e treinamentos, seis porcos consecutivos, com dissecção aórtica e interposição de um enxerto de dácron em um segmento da aorta infra-renal abdominal, com técnica totalmente laparoscópica.Resultados: Todos os tempos cirúrgicos foram decrescentes ao longo do estudo, apresentando redução de 45,9% no tempo total de cirurgia, 85,8% no tempo de dissecção da aorta, 81,2% na exposição da aorta, 55,1% no clampeamento total, 71% na confecção da anastomose proximal e 64,9% na anastomose distal. Conclusão:O presente estudo mostrou que os resultados técnicos satisfatórios da CVL vascular ocorreram somente após longa curva de aprendizado, que foi decrescente ao longo do tempo, à medida que aumentou a experiência e vivência com os materiais e com a visão não-estereoscópica. Essa técnica pode ser realizada com perfeição por cirurgiões vasculares desde que façam cursos especializados, com treinamento em simuladores e animais, e desde que busquem constante aprimoramento a fim de conseguir resultados similares aos obtidos com a cirurgia convencional.Palavras-chave: Cirurgia videoassistida, aorta, doenças vasculares, aprendizagem, modelos animais. AbstractBackground: Laparoscopic aortic surgery (LAS) is evolving as a minimal invasive alternative technique for the treatment of abdominal aortic aneurysms and peripheral aortoiliac arterial disease. Few articles have objectively evaluated the technique learning curve in vascular surgery.

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The effect of different intraabdominal pressures on lipid peroxidation and protein oxidation status during laparoscopic cholecystectomy

Abstract: The results suggest that both 15 and 10 mmHg of LAP could lead to an increased oxidative stress response during LC, but no difference was found between the groups.

Cited by 74 publications

References 17 publications

Robotic and laparoscopic urologic surgery ischemic preconditioning

Robotic and laparoscopic urologic surgery ischemic preconditioning

The Effects of Different Intraabdominal Pressure Protocols in Laparoscopic Procedures on Oxidative Stress Markers and Morphology in Rat Ovaries

Curva de aprendizado em cirurgia aórtica videolaparoscópica: estudo experimental em porcos

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