The effect of cyfluthrin on testis inhibin B in rats and the intervention of Lycium barbarum polysaccharide

Guo, Xin; Xie, Yongxin; Guo, Chenchen; Wei, Jing-Lin; Hu, Yongmei

doi:10.1007/s13273-021-00120-1

Cited by 1 publication

(5 citation statements)

References 26 publications

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“…Compared with the control group, cyfluthrin group showed edema of sperm cells, changes of intracellular vacuoles, irregular nuclei, and abundant lipid droplets. This was also consistent with our previous research results 5 . At the same time, the results of cell experiment showed that cyfluthrin could induce abnormal changes in the morphology and structure of GC‐2 cells.…”

Section: Discussionsupporting

confidence: 93%

“…This was also consistent with our previous research results. 5 At the same time, the results of cell experiment showed that cyfluthrin could induce abnormal changes in the morphology and structure of GC-2 cells. Combined with the results of animal and cell experiments, cyfluthrin had a certain toxic effect on testis.…”

Section: Discussionmentioning

confidence: 99%

“…Studies have shown that pyrethroid insecticides could damage the reproductive health of adult men by reducing sperm concentration, quality and destroying sperm DNA 12,13 . At the same time, previous studies of our group found that exposure to cyfluthrin could decrease the expression of testicular inhibin α (INHα) and testicular inhibin β B (INHβB) in rats, indicating that cyfluthrin has toxic effect on rat testis 5 . It can be seen that the high residue of pyrethroid pesticides may be one of the important causes of testicular injury.…”

Section: Introductionmentioning

confidence: 88%

“…Therefore, low toxicity and high efficiency pesticides are our first choice at present. Pyrethroid is widely used as a botanical pesticide in the world 5 . Cyfluthrin is an important type II pyrethroid species, which is widely used in the field of sanitary pest control, because of its broad insecticidal spectrum, high efficiency and low toxicity, low residual amount and good biodegradability 6 .…”

Section: Introductionmentioning

confidence: 99%

“…12,13 At the same time, previous studies of our group found that exposure to cyfluthrin could decrease the expression of testicular inhibin α (INHα) and testicular inhibin β B (INHβB) in rats, indicating that cyfluthrin has toxic effect on rat testis. 5 It can be seen that the high residue of pyrethroid pesticides may be one of the important causes of testicular injury. However, its mechanism is not clear.…”

mentioning

confidence: 99%

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The role of stimulator of interferon genes‐mediated AMPK/mTOR/P70S6K autophagy pathway in cyfluthrin‐induced testicular injury

Zhao

Xie

et al. 2022

Environmental Toxicology

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Cyfluthrin is widely used in the field of sanitary pest control by its wide insecticidal spectrum, high efficiency and low toxicity, low residue, and good biodegradability. But, as a double‐edged sword, a large amount of cyfluthrin remains are still in the environment. The residual cyfluthrin is absorbed into the food chain through vegetation and then poses a risk to soil organisms and human health. Several studies have suggested that cyfluthrin is one of the main factors causing testicular damage, but the mechanism remains unclear. In this study, we established in vivo and in vitro models of testicular injury in rats and GC‐2 cells exposed to cyfluthrin to explore whether stimulator of interferon genes (STING) gene mediates the regulation of AMPK/mTOR/p70S6K autophagy pathway, which lays a foundation for further study of the mechanism of testicular injury induced by cyfluthrin. The results showed that the activity of super oxide dismutase in testis decreased and the activity of malonic dialdehyde increased with the increase of concentration in vivo and in vitro. At the same time, the levels of mitochondrial damage and inflammation in the testis also increased, which further activated autophagy. In this process, the increased level of inflammation is related to the increased expression of STING gene, and AMPK/mTOR/p70S6K autophagy pathway is also involved. To sum up, cyfluthrin has certain reproductive toxicity, and long‐term exposure can induce testicular cell damage. STING gene can participate in cyfluthrin‐induced testicular injury through AMPK/mTOR/P70S6K autophagy pathway.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%