volume 40, issue 5, P409-415 2012
DOI: 10.1016/j.jcms.2011.07.012
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Philipp Metzler, Cornelius von Wilmowsky, Robert Zimmermann, Jörg Wiltfang, Karl Andreas Schlegel

Abstract: The aim of this study was to investigate de novo bone formation following ectopic site implantation of bone substitutes covered by periosteum, with and without the application of autologous platelet-rich plasma (PRP). Twenty-four weeks after subcutaneous implantation of various bone substitutes (bovine hydroxyapatite (bHAP), phycogenic hydroxyapatite (pHAP), and bioglass (BG)) in 35 mini-pigs, bone regeneration rates were compared microradiographically and histologically. Without PRP, bHAP showed a mean de nov…

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