The Effect of Curcumin on the Invasion and Migration of Glioma Cells

Abstract

Aim: This study investigated the effect of curcumin, from Curcuma longa, on the invasion of U87 glioma cell line spheres in 3D collagen model. Furthermore, this study investigated the anti-migration effects of curcumin on the migration of the same cell line in scratch assay.
 Place and Duration of Study: Department of Pharmacology, School of Medicine, The University of Jordan, Amman, Jordan, between March 2019 and May 2019.
 Methods: 3D invasion assay and 2D migration assays were used to fulfill these aims in addition to the Image J program that was used to analyze the area of invasion and the area of migration over the days of applying the assays.
 Results: The results showed an inhibitory effect of curcumin in all samples tested on both the invasion and migration of U87 cell line.
 Conclusion: This work adds more proofs on the importance of curcumin as anti-invasive and anti-migration agent and opens the door for more investigative studies.