The effect of corticosteroids on human epidermal mitotic activity

Fisher, Louis B.

doi:10.1001/archderm.103.1.39

Cited by 46 publications

(16 citation statements)

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“…4, groups treated with HCB and CP had more pigment retention during the irradiation pause, which may have caused the longer time to onset of tumor formation when compared to the SSR-irradiated controls without corticosteroid treatments. In general, the corticosteroidtreated groups were more pigmented than the vitamin D3treated and control groups, possibly due to the antimitotic effect of corticosteroids (26,27). Less cell turnover would result in sustained pigmentation compared to the mice who received only UV-irradiation.…”

Section: Discussionmentioning

confidence: 95%

Topical hydrocortisone, clobetasol propionate, and calcipotriol do not increase photocarcinogenesis induced by simulated solar irradiation in hairless mice

Lerche

Philipsen

Poulsen³

et al. 2010

Experimental Dermatology

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Topical corticosteroids such as hydrocortisone-17-butyrate (HCB) and clobetasol-17-propionate (CP) and vitamin D(3) derivatives such as calcipotriol (CAL) are widely used to treat psoriasis. The immunosuppressive effects of corticosteroids make their topical use a concern for skin carcinogenicity. Few studies have assessed the effect of topical corticosteroids and topical vitamin D(3) derivatives on photocarcinogenesis induced by ultraviolet radiation. We investigated whether HCB, CP, or CAL can accelerate photocarcinogenesis using simulated solar radiation (SSR). HCB, CP, or CAL was applied topically to the backs of hairless, female, C3.Cg/TifBomTac-immunocompetent mice in 16 groups of 25 mice each. The drugs were applied three times weekly followed by 0, 2, 4, or 6 standard erythema doses (SED) of SSR for 365 days or until death. No change was observed in the time required for tumor development in mice treated with HCB and 2 SED (HCB-2SED) and HCB-6SED. However, the time required for tumor development increased with HCB-4SED treatment. Treatment with CP-2SED did not change the time to onset of the first and second tumor, but all other CP treatments in combination with SSR increased the time. CAL-2SED decreased the time to onset of the first tumor but not of the second and third tumor. CAL-4SED and CAL-6 SED did not change or increased the time to tumor development. Our data indicated that topical administration of HCB and CAL did not alter the photocarcinogenesis of SSR and that topical CP administration had a photoprotective effect. Thus, HCB, CP, and CAL do not increase photocarcinogenesis induced by SSR.

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Section: Discussionmentioning

confidence: 95%

Topical hydrocortisone, clobetasol propionate, and calcipotriol do not increase photocarcinogenesis induced by simulated solar irradiation in hairless mice

Lerche

Philipsen

Poulsen³

et al. 2010

Experimental Dermatology

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“…that corticosteroids may inhibit KA growth by inhibiting the hair growth cycle in the anagen phase (Sanders et al, 2002;Stenn, Paus, Dutton, & Sarba, 1993). The authors also suggested that these agents may inhibit the keratinocyte hyperplasia via interfering with the epidermal mitotic activity (Fisher & Maibach, 1971), DNA synthesis (Schwarz, Viaje, & Slaga, 1977) and the transcription of transforming growth factor (TGF-a) production in keratinocytes (Lee, Morhenn, Ilnicka, Eugui, & Allison, 1991 with KA whose lesions arose in the setting of prurigo nodularis also benefited from the therapy when intralesional corticosteroids were used in combination with systemic retinoids (Wu et al, 2013).…”

Section: Corticosteroidsmentioning

confidence: 99%

Intralesional therapy for the treatment of keratoacanthoma

Kiss

Avci

Bánvölgyi

et al. 2019

Dermatologic Therapy

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Keratoacanthoma (KA) is a common epidermal tumor that originates from the hair follicle of the skin. It is generally considered as a benign neoplasm, but in rare cases, it can also transform into squamous cell carcinoma. Although surgical excision with a safety margin is considered to be the gold standard treatment for most subtypes of KA, several other treatment options are also available. Intralesional therapy is one of these options, which could be cosmetically and functionally a better alternative to surgical removal, while it provides similar outcomes. It is more effective than topical treatments, yet fewer side effects may be seen than in systemic treatments. Based on the literature, the most commonly used intralesional agent is methotrexate, followed by 5‐fluorouracil and interferon alpha. Regardless of the advantages, which make intralesional therapy a desirable treatment alternative, guidelines for the intralesional treatment of KA are not yet established. A histopathological confirmation before the start of treatment is still recommended to prevent any possible misdiagnosis of KA for SCC. In our present study, we set out to review the current state of the art of the intralesional treatment of KA.

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“…Synthetic corticosteroids have been widely used in dermatology because of their anti-inflammatory potency. They also exert, when administered in pharmacological doses, antimitotic actions on human epidermis (Fisher & Maibach, 1971;Fry & McMinn, 1968). When the antimitotic and anti-inflammatory capacities of these steroids are linked, thinning of the epidermis, which is explained in terms of cell proliferation, is an unavoidable side-effect of therapy (Winter & Burton, 1974).…”

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confidence: 99%

A histometric and autoradiographic study of hydrocortisone action in cultured human epidermis

Tammi

1981

British Journal of Dermatology

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Pieces of human skin maintained their viability, grew and differentiated for at least 10 days in chemically defined (serum-free) culture conditions. Physiological concentrations of hydrocortisone, added to the cultures, were shown to cause thinning of epidermis, which was due to decreased rate of epidermal proliferation. The relative volume of normal, orthokeratotic stratum corneum with underlying granular cells was increased concomitantly with epidermal thinning. The present findings show that even small concentrations of the hormone influence epidermal cell proliferation and suggest that hydrocortisone has a physiological role in keratinization. The possibility of using human skin culture in the assessment of the antiproliferative and atrophogenic action of synthetic glucocorticoids is discussed.

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The effect of corticosteroids on human epidermal mitotic activity

Cited by 46 publications

References 0 publications

Topical hydrocortisone, clobetasol propionate, and calcipotriol do not increase photocarcinogenesis induced by simulated solar irradiation in hairless mice

Topical hydrocortisone, clobetasol propionate, and calcipotriol do not increase photocarcinogenesis induced by simulated solar irradiation in hairless mice

Intralesional therapy for the treatment of keratoacanthoma

A histometric and autoradiographic study of hydrocortisone action in cultured human epidermis

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