The effect of Codonopis bulleynana Forest ex Diels on chronically constipated mice

Abstract

To verify the laxative effect of Codonopsis bulleyana and its effect on intestinal microbiota, a long-term constipation model was established using 3.0 mg/kg loperamide hydrochloride, after which, the long-term constipation model was administered by 0.2 g/ml high-dose Codonopsis bulleyana water extract. The therapeutic effects were observed by measuring defecation amount and feces moisture content. The composition of intestinal microbiota was detected and analyzed using16S rDNA sequencing technology. The results showed that Codonopsis bulleyana water extract can increase stool quantity and promote intestinal tract movement in constipated mice. Obvious changes were shown in intestinal microbiota of chronically constipated mice treated with Codonopsis bulleyana water extract as the proportion of beneficial bacteria increased in the model treated by Codonopsis bulleyana . Codonopsis bulleyana water extract alleviates constipation symptoms caused by loperamide hydrochloride and improves the intestinal microbiota in constipated mice.

Microbiome-metabolomics deciphers the effects of Cistanche deserticola polysaccharides on aged constipated rats

“…8,9 An imbalance of intestinal microbiota is one of the major causes of constipation. 47 In this study, we found that gut microbiota had changed greatly in the aged constipated rats, including reduction of intestinal bacterial diversity at the class, order, and genus levels, as well as the abnormalities of 9 gut microbiota. Such changes of gut microbiota lead to chronic constipation in rats.…”

Advancements in the investigation of chemical components and pharmacological properties of Codonopsis: A review

“…Its water extract acts as a laxative in constipated mice. [108] Superfine powder of Codonopsis safeguards the gastric mucosa in rats with gastric ulcers. [109] Flavonoids from Codonopsis facilitate cell migration in small intestinal epithelial cells, countering the migration inhibition caused by DFMO or 4-AP and potentially increasing cellular arginine through polyamine signaling pathway modulation.…”

“…Figure 4 illustrates the phenylpropanoids extracted from Codonopsis are primarily composed of tangshenoside I-VI (102-107), [45] 3,4-dihydroxyphenethyl-5-hydroxy-4-oxopentanoate (108) (112), and 3,4-dihydroxyphenylethano1-8-O-[β-d-apiofuranosyl (1→2)]-β-d-glucopyranoside (113). [46] Additionally, newly identified compounds include tangshenoside VIII (114), syringin (115), [47] methlysyringin (116), [48] lanceolune A-C (117-119), [49] cordifoliketone A-B (120-121), [50] ethylsyringin (122), [27] codonoside A (123), codonoside B (124), [51] and coniferoside (125).…”

The Potential of Polysaccharides from Various Plants as Constipation Treatment

“…This condition will affect changes in the composition of microbiota diversity, where the number of harmful bacteria (such as Fusobacterium) will increase. In contrast, the number of good bacteria (such as Bifidobacterium, Bacteroides, and Lactobacillus) will decrease (Luan et al, 2019). Measuring the weight of wet feces per day is the indicator most often used to assess the presence or absence of constipation in individuals.…”

“…Measuring the weight of wet feces per day is the indicator most often used to assess the presence or absence of constipation in individuals. Normal feces weigh around 150 g/day, and the bacteria in the feces are more diverse in normal mice (Cummings et al, 1992;Luan et al, 2019).…”