The effect of Citalopram in panic disorder

Abstract

The most advantageous benefit/risk ratio for the treatment of PD was associated with citalopram 20 or 30 mg/day.

World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Pharmacological Treatment of Anxiety, Obsessive-Compulsive and Post-Traumatic Stress Disorders – First Revision

“…Á Citalopram was effective in a placebo-and comparator-controlled trial (Wade et al 1997) and one comparison with fluoxetine (Amore et al 1999b). In a relapse prevention study over 52 weeks, it was superior to placebo and as effective as the TCA clomipramine (Lepola et al 1998).…”

“…In a 26-week long-term study, it was as effective as fluoxetine (Amore et al 1999a) (A). Á Clomipramine also showed efficacy in DBPC Johnston et al 1988) and comparator-controlled studies (Cassano et al 1988;Fahy et al 1992;Modigh et al 1992;Wade et al 1997).…”

Evidence-based pharmacotherapy of panic disorder

“…Within the TCAs, both imipramine and clomipramine have been studied (Cross National Collaborative Panic Study, Second Phase Investigators, 1992;Papp et al, 1997). The currently available SSRIs citalopram, escitalopram, fluvoxamine, fluoxetine, paroxetine, and sertraline have all been proven more effective than pill-placebo in reducing symptomatology in PD (Ballenger et al, 1998a;Black et al, 1993;Hoehn-Saric et al, 1993;Lecrubier et al, 1997;Michelson et al, 1998;Rapaport et al, 1998;Sharp et al, 1996;Wade et al, 1997). The daily dosages of these antidepressants are similar to those used in the treatment of major depressive disorder (see Table 1).…”

“…Relatively few studies have compared different antidepressants in PD (Bakker et al, 1999;Cassano et al, 1988;den Boer et al, 1987 ;den Boer and Westenberg, 1988;Lecrubier et al, 1997;Modigh et al, 1992;Nair et al, 1996;Seedat et al, 2003 ;Tiller et al, 1997;Wade et al, 1997). In most studies, different antidepressants have shown equal efficacy in reducing the total number of panic attacks.…”

“…In most studies, different antidepressants have shown equal efficacy in reducing the total number of panic attacks. In particular, comparison of TCAs and SSRIs has not found differences in efficacy between these classes of medication (Bakker et al, 1999;Lecrubier et al, 1997;Otto et al, 2001;Wade et al, 1997). Some data suggests that SSRIs have a more rapid onset of action than TCAs (Lecrubier et al, 1997), and that SSRIs are associated with a lower drop-out rate (Bakker et al, 2002).…”