The effect of chronic propranolol treatment on overnight plasma levels of anterior pituitary and related hormones.

Self Cite

1 Chronic propranolol treatment has been previously shown to lower the plasma concentrations of LH and prolactin in normal male volunteers. 2 The effect of 2 weeks treatment with propranolol (80 mg twice daily) on the plasma concentrations of LH and prolactin has now been investigated in five post menopausal hypertensive women. 3 There was no significant effect of propranolol treatment on the basal plasma concentrations of either hormone. Both hormones showed significant increases in plasma concentration following GnRH stimulation and these increases were also unaffected by propranolol treatment.

Section: Discussioncontrasting

confidence: 94%

Section: Introduction Methodsmentioning

confidence: 99%

The effect of propranolol on luteinising hormone and prolactin plasma concentrations in hypertensive women.

Dart¹,

McHardy²,

Barber³

1982

Self Cite

“…On withdrawal of bopindolol an increase in PRL levels was observed to occur from the 11th to the 21st day of observation but after atenolol on only one occasion (on day 21). Dart et al (1981) report no rebound increase of PRL or cortisol 48 h after propranolol was stopped. Our finding, from observation of cortisol levels during 21 days after drug withdrawal was, that following atenolol, there were small increases (days 1, 3 = E a ._ 0) C Cm C 0) E CD Co and 9 pre-isoprenaline and days 1 and 3 postisoprenaline), suggesting a rebound of sympathetic nervous system activity.…”

Section: Discussionmentioning

confidence: 84%

“…Lewis et al (1981) (1980) showed that very high doses of propranolol increased PRL. In man a reduction in overnight PRL was demonstrated following propranolol 80 mg twice daily given to healthy male volunteers for 6 weeks (Dart et al, 1981). Cortisol levels were not changed and there was no evidence of a rebound in hormone levels 48 h after withdrawal.…”

Section: Discussionmentioning

confidence: 88%

Withdrawal phenomena after atenolol and bopindolol: hormonal changes in normal volunteers.

Walden¹,

Tomlinson²,

Graham³

et al. 1990

1. In order to observe and compare the withdrawal phenomena which follow treatment with the beta‐adrenoceptor blocking drugs, bopindolol (with partial agonist activity PAA) and atenolol (without PAA), two groups of six normal volunteers were studied before, during and after 16 days drug administration. 2. Measurements of plasma levels of cortisol, prolactin, insulin, noradrenaline, adrenaline, glucose and potassium were made during a pre‐treatment baseline period, on maximum dose and for 21 days after drug withdrawal. Isoprenaline infusions were given to determine sensitivity of heart rate responses and haemodynamic changes measured in response to physiological manoeuvres. 3. Following atenolol withdrawal the results show hormonal evidence of adrenergic overactivity in the form of elevation of plasma cortisol, insulin and glucose levels. After bopindolol withdrawal there was, in contrast, an overshoot of plasma prolactin and a persistent elevation of plasma potassium and adrenaline post‐isoprenaline. 4. The hormonal changes which follow withdrawal of atenolol and bopindolol are associated with haemodynamic changes reported elsewhere (Walden et al., 1990). 5. These observations provide confirmatory evidence of a post beta‐adrenoceptor blockade withdrawal syndrome which differs between the two drugs studied and this may reflect the properties of the drugs, in particular the PAA of bopindolol.

“…In view of changes in the secretion pattern of anterior pituitary hormones induced by propranolol therapy (Dart et al, 1981) it was justified to look for a sex-influence in changes in biochemistry caused by propranolol. Furthermore, almost all the studies mentioned above on blood lipids were done in men while most studies on thyroid hormones were performed in women.…”

Section: Discussionmentioning

confidence: 99%

Changes in blood chemistry in hypertensive patients during propranolol therapy.

Andreasen¹,

Jakobsen²,

Kornerup³

et al. 1984

Propranolol induced changes in blood plasma chemistry were followed in thirty hypertensive patients (WHO I‐II) who were seen each week during 14‐15 weeks. The initial 4 weeks were a drug free period and the next 2 weeks were a drug adjustment period. After that the patients were on an unchanged propranolol dose for 8 weeks (40, 80 or 160 mg four times daily). For all observed changes the correlation was studied to (1) dose, (2) free and total simultaneously determined plasma concentration and (3) free and total average plasma concentration of unchanged drug during the preceding 24 h period. Total protein and albumin did not change significantly. After 4 and 8 weeks on the final dose orosomucoid was increased significantly (by 10%) compared with the value from the end of the drug free period. Creatinine rose significantly during the initial 4‐6 weeks therapy to remain at the same level during the last 4 weeks. Urate was increased at the two lowest dose levels. Total cholesterol fell significantly (5%) while triglycerides increased significantly (16%). T4 rose significantly, T3 fell and r‐T3 rose significantly in a dose dependent way. Interindividually r‐T3 was the only biochemical change showing a significant relationship to the propranolol plasma concentration. The relationship reached the highest level of significance to the average 24 h free concentration.