The effect of chronic administration of antidepressants and electroconvulsive shock on the 5-HT1A receptor mediated hypothekmic response induced by 8-OH-DPAT in the rat

Assessing the Neuronal Serotonergic Target-based Antidepressant Stratagem: Impact of In Vivo Interaction Studies and Knockout Models

“…Microdialysis study in rats indicated that antidepressant-like effects of serotonergic drugs were potentiated by 5-HT 1A autoreceptor blockade [260]. 5-HT 1A function is also involved in effectiveness of electroconvulsive shock treatment as observed from and hypothermic responses in rats [329] and electrophysiological analysis of rat hippocampal slices [139]. Normalization of 5-HT synthesis was associated with antidepressant-like effect of chronic buspirone (5-HT 1A partial agonist) treatment [320].…”

Assessing the Neuronal Serotonergic Target-based Antidepressant Stratagem: Impact of In Vivo Interaction Studies and Knockout Models

“…Microdialysis study in rats indicated that antidepressant-like effects of serotonergic drugs were potentiated by 5-HT 1A autoreceptor blockade [260]. 5-HT 1A function is also involved in effectiveness of electroconvulsive shock treatment as observed from and hypothermic responses in rats [329] and electrophysiological analysis of rat hippocampal slices [139]. Normalization of 5-HT synthesis was associated with antidepressant-like effect of chronic buspirone (5-HT 1A partial agonist) treatment [320].…”

Assessing the Neuronal Serotonergic Target-based Antidepressant Stratagem: Impact of In Vivo Interaction Studies and Knockout Models

“…Microdialysis study in rats indicated that antidepressant-like effects of serotonergic drugs were potentiated by 5-HT 1A autoreceptor blockade [260]. 5-HT 1A function is also involved in effectiveness of electroconvulsive shock treatment as observed from and hypothermic responses in rats [329] and electrophysiological analysis of rat hippocampal slices [139]. Normalization of 5-HT synthesis was associated with antidepressant-like effect of chronic buspirone (5-HT 1A partial agonist) treatment [320].…”

Assessing the Neuronal Serotonergic Target-based Antidepressant Stratagem: Impact of In Vivo Interaction Studies and Knockout Models

“…Microdialysis study in rats indicated that antidepressant-like effects of serotonergic drugs were potentiated by 5-HT 1A autoreceptor blockade [260]. 5-HT 1A function is also involved in effectiveness of electroconvulsive shock treatment as observed from and hypothermic responses in rats [329] and electrophysiological analysis of rat hippocampal slices [139]. Normalization of 5-HT synthesis was associated with antidepressant-like effect of chronic buspirone (5-HT 1A partial agonist) treatment [320].…”