The Effect of Chemical Carcinogens on Virus-Induced Rabbit Papillomas

Rous, Peyton; Friedewald, William F.

doi:10.1084/jem.79.5.511

Cited by 96 publications

(18 citation statements)

References 19 publications

(16 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Early observations on synergistic interactions between viruses and chemical carcinogens in an animal system were already noted in the 1930s and 1940s ( e.g. , Ref 61…”

Section: Food Contamination With Virusesmentioning

confidence: 93%

Red meat consumption and cancer: Reasons to suspect involvement of bovine infectious factors in colorectal cancer

Hausen

2012

Intl Journal of Cancer

103

View full text Add to dashboard Cite

An increased risk for colorectal cancer has been consistently reported for long-time consumption of cooked and processed red meat. This has frequently been attributed to chemical carcinogens arising during the cooking process of meat. Long-time fish or poultry consumption apparently does not increase the risk, although similar or higher concentrations of chemical carcinogens were recorded in their preparation for consumption. The geographic epidemiology of colorectal cancer seems to correspond to regions with a high rate of beef consumption. Countries with a virtual absence of beef in the diet (India) or where preferably lamb or goat meat is consumed (several Arabic countries) reveal low rates of colorectal cancer. In China, pork consumption has a long tradition, with an intermediate colorectal cancer rate. In Japan and Korea, large scale beef and pork imports started after World War II or after the Korean War. A steep rise in colorectal cancer incidence was noted after 1970 in Japan and 1990 in Korea. The consumption of undercooked beef (e.g., shabu-shabu, Korean yukhoe and Japanese yukke) became very popular in both countries. The available data are compatible with the interpretation that a specific beef factor, suspected to be one or more thermoresistant potentially oncogenic bovine viruses (e.g., polyoma-, papilloma-or possibly single-stranded DNA viruses) may contaminate beef preparations and lead to latent infections in the colorectal tract. Preceding, concomitant or subsequent exposure to chemical carcinogens arising during cooking procedures should result in increased risk for colorectal cancer synergistic with these infections.

show abstract

“…Early observations on synergistic interactions between viruses and chemical carcinogens in an animal system were already noted in the 1930s and 1940s ( e.g. , Ref 61…”

Section: Food Contamination With Virusesmentioning

confidence: 93%

Red meat consumption and cancer: Reasons to suspect involvement of bovine infectious factors in colorectal cancer

Hausen

2012

Intl Journal of Cancer

103

View full text Add to dashboard Cite

show abstract

“…Tobacco smoke has long been implicated as a carcinogenic factor. Six decades ago, tar was reported to be carcinogenic in rabbit papillomas 94 . In 1990, several studies supported smoking as an independent risk factor for CC.…”

Section: Environmental Cofactorsmentioning

confidence: 99%

“…Six decades ago, tar was reported to be carcinogenic in rabbit papillomas. 94 In 1990, several studies supported smoking as an independent risk factor for CC. However, evidence was not sufficient in humans to rule out shared behavioural risk factors as the cause of this correlation until the late 1990s.…”

Section: Ionizing Radiationmentioning

confidence: 99%

The oncogenic potential of human papillomaviruses: a review on the role of host genetics and environmental cofactors

et al. 2007

View full text Add to dashboard Cite

Human papillomaviruses (HPVs), with over 100 genotypes, are a very complex group of human pathogenic viruses. In most cases, HPV infection results in benign epithelial proliferations (verrucae). However, oncogenic types of HPV may induce malignant transformation in the presence of cofactors. For example, over 99% of all cervical cancers and a majority of vulval, vaginal, anal and penile cancers are the result of oncogenic HPV types. Such HPV types have been increasingly linked to other epithelial cancers involving the skin, larynx and oesophagus. Although viral infection is necessary for neoplastic transformation, evidence suggests that host and environmental cofactors are also required. Research investigating HPV oncogenesis is complex and quite extensive. The inability to produce mature HPV virions in animal models has been a major limitation in fully elucidating the oncogenic potential and role of associated cofactors in promoting malignant transformation in HPV-infected cells. We have reviewed the literature and provide a brief account of the current understanding of HPV oncogenesis, emphasizing the role of genetic susceptibility, immune response, and environmental and infectious cofactors.

show abstract

“…In the case of potentially oncogenic animal papillomaviruses such as BPV type 1 and cottontail rabbit papillomavirus, cofactors clearly play a role in the progression of a benign lesion to a malignant one (65,160). Because HPV (even HPV-16) infection does not invariably lead to the development of cancer, it is quite likely that other factors are also involved in human carcinogenesis associated with HPV (224, 225).…”

Section: Role Of Cofactors In Cervical Carcinogenesismentioning

confidence: 99%

Human papillomaviruses: are we ready to type?

Roman

Fife

1989

Clin Microbiol Rev

View full text Add to dashboard Cite

The issue of determining which human papillomavirus (HPV) is present in a clinical specimen (typing specimens for HPVs) is receiving attention because HPVs cause condyloma acuminata and are associated with the continuum of disease which ranges from dysplasia to invasive genital cancer. Morphological inspection of precancerous lesions is not sufficient to determine which lesions will progress and which will not. A number of research tools based primarily on deoxyribonucleic acid hybridization have been developed. These permit identification and typing of HPV in genital tract scrapings or biopsies. Some HPV types (e.g., HPV-16 and HPV-18) have been identified in high-grade dysplasias and carcinomas more commonly than other types (e.g., HPV-6) and have been designated "high risk" types for cervical cancer. Thus, the question arises whether HPV typing would improve patient management by providing increased sensitivity for detection of patients at risk or by providing a prognostic indicator. In this review, the available typing methods are reviewed from the standpoint of their sensitivity, specificity, and ease of application to large-scale screening programs. Data implicating HPVs in the genesis of genital tract cancers are reviewed, as is the association of specific HPV types with specific outcomes. We conclude that there is currently no simple, inexpensive assay for HPV types, although such assays may be developed in the future. Analysis of the typing data indicates that, while HPV types can be designated high risk and low risk, these designations are not absolute and thus the low-risk group should not be ignored. In addition, interpretation of the data is complicated by finding high-risk types in individuals with no indication of disease. Insufficient data exist to indicate whether knowledge of the presence of a given HPV type is a better prognostic indicator than cytological or histological results. Thus, more research is needed before it can be determined whether typing information will augment the method currently in use for deciding treatment regimen and whether it warrants widespread use.

show abstract

The Effect of Chemical Carcinogens on Virus-Induced Rabbit Papillomas

Cited by 96 publications

References 19 publications

Red meat consumption and cancer: Reasons to suspect involvement of bovine infectious factors in colorectal cancer

Red meat consumption and cancer: Reasons to suspect involvement of bovine infectious factors in colorectal cancer

The oncogenic potential of human papillomaviruses: a review on the role of host genetics and environmental cofactors

Human papillomaviruses: are we ready to type?

Contact Info

Product

Resources

About