The effect of catecholamines on the glucose uptake in brown adipose tissue demonstrated by 18F-FDG PET/CT in a patient with adrenal pheochromocytoma

Yamaga, Lilian Yuri Itaya; Thom, A.; Wagner, Jairo; Baroni, Ronaldo Hueb; Hidal, Jairo Tabacow; Funari, M.B.G.

doi:10.1007/s00259-007-0538-7

Cited by 40 publications

(33 citation statements)

References 5 publications

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“…However, fat tissue with modestly increased CT HUs may be indistinguishable from panniculitis or lipid-containing tumor tissue (15). Some reports have suggested that the 18 F-FDG uptake level of BAT in patients with pheochromocytoma may be affected by the serum level of catecholamines (16,17). Our findings suggest that direct measurement of CT HUs can help confirm fat density to be activated BAT.…”

Section: Discussionmentioning

confidence: 56%

CT Hounsfield Units of Brown Adipose Tissue Increase with Activation: Preclinical and Clinical Studies

Baba¹,

et al. 2010

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Brown adipose tissue (BAT) densities assessed as CT Hounsfield units (HUs) were evaluated in a rodent model and in patients to determine whether HUs changed in relation to BAT activity. Methods: Serial 18 F-FDG PET/CT was performed on rats under both room temperature control conditions and after 4 h of coldstimulation, which is known to activate BAT. The maximum standardized uptake values and CT HUs of BAT were measured, and tissues were examined in the laboratory. Image records from cancer patients who underwent PET/CT were reviewed, and 23 patients were identified who displayed both high and low 18 F-FDG uptake into BAT on serial 18 F-FDG PET/CT scans. The maximum standardized uptake values and CT HUs of BAT were compared in these scans. Results: The mean (6SD) CT HUs of cold-activated BAT (212.4 6 22.4) were significantly higher than those (227.9 6 9.6) of the controls in the rat model. The CT HUs of BAT (271.6 6 18.0) in the patients with high 18 F-FDG uptake were significantly higher than those (2104.4 6 16.8) of the patients with low 18 F-FDG uptake . A decrease in relative lipid content is seen in activated BAT in rats on histology. Conclusion: The CT HUs of BAT increased in activated conditions in both animals and patients, likely because of lipid consumption by activated BAT.

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Section: Discussionmentioning

confidence: 56%

CT Hounsfield Units of Brown Adipose Tissue Increase with Activation: Preclinical and Clinical Studies

Baba¹,

et al. 2010

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“…Pheochromocytoma has been reported to be a cause of 18 F-FDG uptake into brown fat, and extensive 18 F-FDG uptake into perirenal brown fat has also been reported [15][16][17][18]. To our knowledge, however, there is no report about the difference in SUV between brown fat with pheochromocytoma and brown fat without pheochromocytoma.…”

Section: Increasedcontrasting

confidence: 40%

Perirenal 18F-FDG Uptake in a Patient with a Pheochromocytoma

Park

Byun

Jung³

et al. 2014

Nucl Med Mol Imaging

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“…84 This increased uptake of [ 18 F]FDG is abolished after removal of the tumor. 82,83 These studies indicate that an adrenergic environment can drive browning of various WAT depots in human adults. However, the susceptibility of the different human WAT depots to browning and the estimated percentage of WAT that can be browning are still unknown, and, therefore, the amount of WAT browning that contributes to metabolic health remains to be elucidated.…”

Section: Because [mentioning

confidence: 99%

“…This is nicely illustrated by a markedly increased brown fat mass and energy expenditure in patients who have a pheochromocytoma, a catecholamine-producing neuroendocrine tumor. 81 Patients have increased uptake of [ 18 F]FDG in the classical brown fat depots, as well as in other fat depots including perirenal fat 82,83 and omental fat. 84 This increased uptake of [ 18 F]FDG is abolished after removal of the tumor.…”

Section: Because [mentioning

confidence: 99%

Role of Brown Fat in Lipoprotein Metabolism and Atherosclerosis

Hoeke

Kooijman

Boon

et al. 2016

Circulation Research

146

138

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Atherosclerosis, for which hyperlipidemia is a major risk factor, is the leading cause of morbidity and mortality in Western society, and new therapeutic strategies are highly warranted. Brown adipose tissue (BAT) is metabolically active in human adults. Although positron emission tomography-computed tomography using a glucose tracer is the golden standard to visualize and quantify the volume and activity of BAT, it has become clear that activated BAT combusts fatty acids rather than glucose. Here, we review the role of brown and beige adipocytes in lipoprotein metabolism and atherosclerosis, with evidence derived from both animal and human studies. On the basis of mainly data from animal models, we propose a model in which activated brown adipocytes use their intracellular triglyceride stores to generate fatty acids for combustion. BAT rapidly replenishes these stores by internalizing primarily lipoprotein triglyceride-derived fatty acids, generated by lipoprotein lipasemediated hydrolysis of triglycerides, rather than by holoparticle uptake. As a consequence, BAT activation leads to the generation of lipoprotein remnants that are subsequently cleared via the liver provided that an intact apoElow-density lipoprotein receptor pathway is present. Through these mechanisms, BAT activation reduces plasma triglyceride and cholesterol levels and attenuates diet-induced atherosclerosis development. Initial studies suggest that BAT activation in humans may also reduce triglyceride and cholesterol levels, but potential antiatherogenic effects should be assessed in future studies. (Circ Res. 2016;118:173-182.

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The effect of catecholamines on the glucose uptake in brown adipose tissue demonstrated by 18F-FDG PET/CT in a patient with adrenal pheochromocytoma

Cited by 40 publications

References 5 publications

CT Hounsfield Units of Brown Adipose Tissue Increase with Activation: Preclinical and Clinical Studies

CT Hounsfield Units of Brown Adipose Tissue Increase with Activation: Preclinical and Clinical Studies

Perirenal 18F-FDG Uptake in a Patient with a Pheochromocytoma

Role of Brown Fat in Lipoprotein Metabolism and Atherosclerosis

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