volume 6, issue 10, P900-912 2014
DOI: 10.18632/aging.100700
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Denise S. Wiesenborn, Vinal Menon, Xu Zhi, Andrew Do, Adam Gesing, Zhihui Wang, Andrzej Bartke, Deborah A. Altomare, Michal M. Masternak

Abstract: Long-living Ames dwarf (df/df) mice are homozygous for a mutation of the Prop1df gene. As a result, mice are deficient in growth hormone (GH), prolactin (PRL) and thyrotropin (TSH). In spite of the hormonal deficiencies, df/df mice live significantly longer and healthier lives compared to their wild type siblings. We studied the effects of calorie restriction (CR) on the expression of insulin signaling genes in skeletal muscle and adipose tissue of normal and df/df mice. The analysis of genes expression showed…

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