The Effect of Boron on Some Biochemical Parameters in Experimental Diabetic Rats

Abstract

In this study, we evaluated the effect of boron (B) as boric acid (BA) on body weight (b.w.); blood glucose; plasma insulin; lipase and paraoxonase (PON1) activities; and serum triglyceride, total cholesterol, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol, lipid peroxidation (MDA), and total antioxidant capacity (TAC) in streptozotocin (STZ)-induced experimental diabetes in rats. Sixty Wistar albino rats (200-250 g) were divided into six groups of ten. The groups received the following treatment: group 1, control group; group 2, 50 mg/kg (b.w.) i.p. STZ-induced diabetes; group 3, 5 mg/kg (b.w.) B; group 4, 10 mg/kg (b.w.) B; group 5, diabetes + 5 mg/kg (b.w.) B; and group 6, diabetes + 10 mg/kg (b.w.) B. The experiment lasted 4 weeks. Increased serum MDA levels with diabetes were significantly reduced and although it is not statistically significant, serum TAC levels approached to values of control group; also, insignificant increases were observed in HDL cholesterol levels in experimental diabetic rats with treatment 5 and 10 mg/kg B. Furthermore, body weight, plasma insulin, and lipase activities increased insignificantly, blood glucose and serum LDL cholesterol decreased significantly, and total cholesterol levels decreased insignificantly in the diabetes + 10 mg/kg B group. There was no difference between the groups in terms of plasma PON1 activities and serum triglyceride levels. In conclusion, B may have beneficial effects on some biochemical parameters changes in experimental diabetes, and in order to determine the full effect of this element on the metabolism, further studies are required which use various dosages and compounds of B.

Investigation the Effect of Boric Acid effect on Antioxidant System, HDL Levels and PON Activity on Rats Feding to the High-Fat Diet

“…Aslan et al as a result of the study conducted by, it was reported that HDL and PON activity decreased when oxidative stress increased in obese individuals (Aslan et al, 2011). It shows a decrease in the activation of the PON enzyme, which is a strong antioxidative agent, with the oxidant load and advanced glycation reactions that occur in obesity (Cakir et al, 2018;Cervellati et al, 2018;Yu et al, 2017). This may explain the decrease in PON activity measured in the high-fat diet group in our study.…”

Boron Compounds Mitigate 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Induced Toxicity in Human Peripheral Blood Mononuclear Cells

“…Consequently, the activities of antioxidant enzymes play a significant role in cellular defense. Reports suggest that compounds containing boron have the potential to enhance the activity of antioxidant enzymes by reducing lipid peroxidation [ 58 ]. Another study indicates that boron treatment can effectively limit oxidative damage by increasing the body’s glutathione stores and inhibiting the formation of other reactive oxygen species [ 59 ].…”

Casticin Mitigates Renal Damage Injured by Ischemia Reperfusion: A Biochemical Study

“…Tissue MDA level is a valuable indicator of lipid peroxidation 40 . Likewise, MDA supports oxidative stress by producing ROS 41,42 . The oxidative stress can be predicted by some indicative assessments like MDA, TOS, TAS, and OSI, which display the balance of redox reactions between oxidation and antioxidation 43 .…”