The effect of body mass index and its interaction with family history on hypertension: a case–control study

Li, An-le; Peng, Qian; Shao, Yue-qin; Fang, Xiang; Zhang, Yiying

doi:10.1186/s40885-019-0111-2

Cited by 28 publications

(28 citation statements)

References 33 publications

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“…It's well known that the genetic factors play an important basic role in the occurrence of hypertension, and family history is a sign reflecting the main role of genetic factors. It's showed that family history plays an important role in the development of hypertension through interaction with acquired risk factors such as body mass index (BMI), and the interaction of family history and BMI is greater than the sum of two independent actions [24][25][26][27][28]. In this study, the genetic epidemiological results showed that the prevalence of hypertension in three degree relatives was different.…”

Section: Discussionmentioning

confidence: 82%

Association between family history and essential hypertension in Han population in Shanghai China

Li¹,

Peng²,

Shao³

et al. 2019

Preprint

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Backgrounds Genetic factor is one of important influencing factors of essential hypertension, and family history (FH) is an important marker of genetic factors.Objective To explore the association between family history and essential hypertension in Han population in Shanghai China.Methods The method of case-control study was used,342 cases of hypertension and 342 controls were selected and investigate their nuclear family members in the both study groups. The diagnostic information of hypertension in all relatives of these two groups was investigated. The method of genetic epidemiology research was used to explore the effect of family history.Results The average prevalence of hypertension was 23.32%. The prevalence of hypertension of first-degree relatives was 33.99%; the prevalence of second- degree relatives was 17.60%; the prevalence of third-degree relatives was 13.51%. All prevalence of hypertension of case group relatives was significantly higher than that of control group relatives. The average onset age in population with positive FH is 48.74±11.16 years old, and the average onset age in population with negative FH is 54.38±9.87 years old. The difference about two FH groups showed statistically significant (t=4.589, P<0.001). The average onset age of offspring with father, mother, grandpa, grandma, maternal grandpa or maternal grandma positive was respectively 48.42, 49.16, 39.55, 39.88, 43.67 or 43.64 years old; and the average onset age of children with father, mother, grandpa, grandma, maternal grandpa or maternal grandma negative was respectively 51.90, 51.17, 51.07, 51.08, 50.50 or 50.57 years old. The difference about two groups showed statistically significant.Conclusion Family history had a positive effect on the occurrence of hypertension, and lead to earlier age of onset of offspring. The effects were different among parent and grandparent in Han in Shanghai China.

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Section: Discussionmentioning

confidence: 82%

Association between family history and essential hypertension in Han population in Shanghai China

Li¹,

Peng²,

Shao³

et al. 2019

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…It is well known that the genetic factors play an important basic role in the occurrence of hypertension, and family history is a sign reflecting the main role of genetic factors. It's showed that family history plays an important role in the development of hypertension through interaction with acquired risk factors such as body mass index (BMI), and the interaction of family history and BMI is greater than the sum of two independent actions [23]. In this study, the genetic epidemiological results showed that the prevalence of hypertension in three degree relatives was different.…”

Section: Discussionmentioning

confidence: 75%

Familial aggregation and heritability of hypertension in Han population in Shanghai China: a case-control study

Li¹,

Fang²,

Zhang³

et al. 2019

Clin Hypertens

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Background: To explore the familial aggregation and heritability of hypertension in Han in Shanghai China. Methods: According to l:l matched pairs design, 342 patients of hypertension and 342 controls were selected and investigate their nuclear family members in the case-control study. The method of genetic epidemiology research was used to explore the familial aggregation and heritability of hypertension. Results: The prevalence rate of hypertension of first-degree relatives was significantly higher (34.44%) than that of second-degree relatives (17.60%) and third-degree relatives (13.51%) in Han Population in Shanghai China. Separation ratio p was 0.217, and prevalence rate of case group relatives was higher than that of control group relatives. The results showed a phenomenon of familial aggregation in the distribution of hypertension. The heritability of first-degree relatives was 49.51%; that of second-degree relatives and third-degree relatives were respectively 23.42 and 21.41%. Conclusion: The distribution of essential hypertension has phenomenon of familial aggregation in Han Population in Shanghai China. The separation ratio of essential hypertension in this study shows that essential hypertension conform to the characteristics of multigene genetic disease. The heritability of first-degree relatives is bigger than that of second-degree relatives and third-degree relatives.

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“…It is well known that the genetic factors play an important basic role in the occurrence of hypertension, and family history is a sign reflecting the main role of genetic factors. It's showed that family history plays an important role in the development of hypertension through interaction with acquired risk factors such as body mass index (BMI), and the interaction of family history and BMI is greater than the sum of two independent actions [22]. In this study, the genetic epidemiological results showed that the prevalence of hypertension in three degree relatives was different.…”

Section: Discussionmentioning

confidence: 75%

Association Between Family History and the Onset Age of Essential Hypertension in Han Population in Shanghai China

Li¹,

Peng²,

Shao³

et al. 2019

AJHR

Self Cite

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Genetic factor is one of important influencing factors of essential hypertension, and family history (FH) is an important marker of genetic factors. To explore the association between family history and the onset age of essential hypertension in Han population in Shanghai China. According to l:l matched pairs design, 342 cases of hypertension and 342 controls were selected and investigate their nuclear family members in the case-control study. The diagnostic information of hypertension in all relatives of these two groups was investigated. The method of genetic epidemiology research was used to explore the effect of family history. The average prevalence of hypertension was 23.32%. The prevalence of hypertension of first-degree relatives was 33.99%; the prevalence of second-degree relatives was 17.60%; the prevalence of third-degree relatives was 13.51%. All prevalence of hypertension of case group relatives were significantly higher than that of control group relatives. The average onset age in population with positive FH is 48.74±11.16 years old, and the average onset age in population with negative FH is 54.38±9.87 years old. The difference about two FH groups showed statistically significant (t=4.589, P<0.001).

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The effect of body mass index and its interaction with family history on hypertension: a case–control study

Cited by 28 publications

References 33 publications

Association between family history and essential hypertension in Han population in Shanghai China

Association between family history and essential hypertension in Han population in Shanghai China

Familial aggregation and heritability of hypertension in Han population in Shanghai China: a case-control study

Association Between Family History and the Onset Age of Essential Hypertension in Han Population in Shanghai China

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