The Effect of Blocking a Nutritional Pathway to the Intervertebral Disc in the Dog Model

Hutton, William; Murakami, Hideki; Li, Jun; Elmer, William A.; Yoon, Seung-Hwan; Minamide, Akihito; Akamaru, Tomoyuki; Tomita, Katsuro

doi:10.1097/00024720-200402000-00011

Cited by 41 publications

(44 citation statements)

References 21 publications

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“…86 Injecting cement into the vertebral body to block nutrient transport through the endplate does not lead to disc degeneration within 1 year. 87 The time span for detectable degenerative changes to occur ranges from 1 week for mice 88 to many months for pigs and sheep. 57,81 For comparison, in human adolescents, it takes several years for disc "degeneration" to become apparent after endplate injury, 89 and narrowing in adult human discs progresses at approximately 3% per year.…”

Section: Disc Degeneration: Animal Modelsmentioning

confidence: 99%

What is Intervertebral Disc Degeneration, and What Causes It?

Adams¹,

Roughley²

2006

Spine

1,451

1,288

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Section: Disc Degeneration: Animal Modelsmentioning

confidence: 99%

What is Intervertebral Disc Degeneration, and What Causes It?

Adams¹,

Roughley²

2006

Spine

1,451

1,288

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“…For this purpose, a canine model of insufficient blood supply to the disc was investigated by Hutton and colleagues [56]. To produce the blood supply disturbance, bone cement was injected into the vertebra adjacent to a single or to both endplates of experimental discs.…”

Section: Biological Models Directly Influencing Cellsmentioning

confidence: 99%

Are animal models useful for studying human disc disorders/degeneration?

et al. 2007

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Intervertebral disc (IVD) degeneration is an often investigated pathophysiological condition because of its implication in causing low back pain. As human material for such studies is difficult to obtain because of ethical and government regulatory restriction, animal tissue, organs and in vivo models have often been used for this purpose. However, there are many differences in cell population, tissue composition, disc and spine anatomy, development, physiology and mechanical properties, between animal species and human. Both naturally occurring and induced degenerative changes may differ significantly from those seen in humans. This paper reviews the many animal models developed for the study of IVD degeneration aetiopathogenesis and treatments thereof. In particular, the limitations and relevance of these models to the human condition are examined, and some general consensus guidelines are presented. Although animal models are invaluable to increase our understanding of disc biology, because of the differences between species, care must be taken when used to study human disc degeneration and much more effort is needed to facilitate research on human disc material.Keywords Intervertebral disc degeneration Á Animal models Á In vivo Á In vitro All of the authors contributed equally to this publication and are listed simply in alphabetical order.

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“…Kurunlahti et al (16) reported a strong correlation between narrowed lumbar arteries and decreased apparent diffusion coefficient (ADC) values of intervertebral discs. In contrast, a recent animal study reported no degenerative changes after the endplate nutritional pathway was blocked with polymethyl methacrylate cement (17). The proposed method is also applicable to other tissues of interest, such as the vertebral bone, and can be combined with MR angiography (MRA) for the evaluation of lumbar arteries.…”

Section: Discussionmentioning

confidence: 99%

In vivo quantification of delayed gadolinium enhancement in the nucleus pulposus of human intervertebral disc

Niinimäki

Parviainen

Ruohonen

et al. 2006

Magnetic Resonance Imaging

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Purpose:To quantify the delayed contrast agent enhancement in the nucleus pulposus of the intervertebral disc by means by T1 relaxation time measurements, and to correlate the enhancement with visual grading of disc degeneration. Diffusion of nutrients through the endplate is a key factor in tissue viability in the intervertebral disc. It can be simulated in vivo using magnetic resonance imaging (MRI) by measuring delayed gadolinium (Gd) enhancement of the disc. Materials and Methods:Twenty male volunteers underwent a lumbar spine examination at 1.5T. T2-weighted sagittal images were used to score disc degeneration. T1 relaxation times were measured before and 90 minutes after intravenous administration of Gd-DTPA-BMA by applying a series of sagittal single-slice inversion-recovery fast spin-echo (IR-FSE) scans. Results:A total of 93 discs were analyzed. A statistically significant decrease in the T1 relaxation time of the nucleus pulposus was observed as a result of contrast-agent intake. The percentage change in the T1 relaxation rate for individual discs was up to 126%. A positive trend was observed between the change in the T1 relaxation rate and the grading of disc degeneration. Conclusion:Quantification of delayed enhancement of the intervertebral disc may provide a new means of studying alterations in degenerative disc disease (DDD) that explain the variation in diffusion into the intervertebral disc.

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The Effect of Blocking a Nutritional Pathway to the Intervertebral Disc in the Dog Model

Cited by 41 publications

References 21 publications

What is Intervertebral Disc Degeneration, and What Causes It?

What is Intervertebral Disc Degeneration, and What Causes It?

Are animal models useful for studying human disc disorders/degeneration?

In vivo quantification of delayed gadolinium enhancement in the nucleus pulposus of human intervertebral disc

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