The Effect of Bariatric Surgery on Metabolic Syndrome: A Three-center Experience in Saudi Arabia

Alomar, Abdulrahman; Shaheen, Mohammed F; Almaneea, Abdallh; Althaqeb, Eyad K; Alshahrani, Ziyad M; Jarman, Yazeed A; Alhabdan, Sultan

doi:10.1007/s11695-021-05461-3

Cited by 8 publications

(10 citation statements)

References 19 publications

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“…In our study, the prevalence of MetS in the preoperative period was found to be approximately 74%, which is consistent with the rates reported in the literature. This rate, which decreased to 26% in the postoperative sixth months, is similar to the decrease rates in the literature (17)(18)(19)(20).…”

Section: Discussionsupporting

confidence: 90%

“…It is known that only a six-month period after bariatric surgery is sufficient for body weight to decrease in a way that positively affects primary cardiometabolic risk factors such as DM, hypertension, and dyslipidemia (21). In studies evaluating the change in car- diometabolic risk during this period, there is a significant improvement after surgery in each risk parameter; however, no relationship has been shown between this improvement and the amount of weight loss (19,20). In their study, Gil S. et al investigated the effects of the amount of fat mass lost instead of the total amount of weight loss.…”

Section: Discussionmentioning

confidence: 99%

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Is the Amount of Weight Loss After Bariatric Surgery a Factor Determining Cardiometabolic Risk Reduction?

Çalıkoğlu¹,

Yalin²,

Barbaros³

2022

jmed

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Objective: This study aimed to investigate whether differential weight loss amount appropriately reflects improvements in cardiometabolic health in patients undergoing bariatric surgery.Materials and Methods: Patients who underwent bariatric surgery (BS) and were followed up for six months were divided into three groups according to their weight loss (Group-1: Low weight loss; Group-2: Moderate weight loss; Group-3: High weight loss). Before and after surgery, patients were evaluated for metabolic syndrome (MetS) using waist circumference, blood pressure, glucose, HDL-C, and triglyceride data, and a clustered cardiometabolic risk (CMR) score was obtained for each patient using a calculator available in the literature online. Changes in each MetS criterion and CMR score in the groups before and after the operation, and their relations with each other were compared.Relation of weight loss amount and cardiometabolic risk İstanbul Tıp Fakültesi Dergisi • J Ist Faculty Med 2022;85(4):462-71 of weight loss of the patients does not affect the individual parameters. However, using a scoring system to evaluate and monitor patients' cardiometabolic cluster risks will make it possible to follow the gradual changes in patients after surgery, making interventions by physicians and nutritionists more targeted and efficient.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Is the Amount of Weight Loss After Bariatric Surgery a Factor Determining Cardiometabolic Risk Reduction?

Çalıkoğlu¹,

Yalin²,

Barbaros³

2022

jmed

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“…All these studies demonstrated a positive association between obesity and MetS. MetS resolution was achieved in 72.5% of patients one year postoperatively, which agrees with a previous study that found that 78% of patients who underwent BS recovered from MetS [ 19 ]. Similarly, a previous study reported remission in MetS by 75.8% of patients one year after RYGB [ 20 ].…”

Section: Discussionsupporting

confidence: 88%

Effect of Bariatric Surgery on Metabolic Syndrome, Framingham Risk Scores and Thyroid Function during One-Year Follow-Up: A Saudi Retrospective Study

et al. 2022

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Bariatric surgery (BS) has been demonstrated to achieve sustained weight loss with significant metabolic improvement, including a reduction in cardiovascular disease and diabetes. The aim of this retrospective study is to measure the effect of BS on the Framingham risk score (FRS) and metabolic syndrome (MetS) among patients who underwent bariatric surgery. Additionally, we determine the effect of BS on thyroid-stimulating hormone (TSH) among euthyroid obese patients. A retrospective follow-up study was conducted at King Abdullah Medical City, Makkah, Saudi Arabia. A total of 160 patients underwent BS and completed one-year follow-up visits. Medical history, anthropometric, biochemical, and hormonal parameters were evaluated at baseline and 3–12 months after BS. The International Diabetes Federation (IDF) criteria were used to diagnose MetS. There was a significant decrease in systolic blood pressure (SBP), diastolic blood pressure (DBP), glycated hemoglobin (Hba1c), TSH, low-density lipoprotein (LDL), triglycerides, and total cholesterol (p < 0.001). A significant decrease was seen in MetS, BMI, FRS, SBP, DBP, Hba1c, LDL, triglycerides, cholesterol, and liver enzymes, with a significant increase in high-density lipoprotein levels 12 months postoperatively (p < 0.001). At 12 months, the prevalence of MetS, DM, and HTN and the FRS significantly decreased from 72.5%, 43.1%, 78.1%, and 11.4 to 16.3%, 9.4%, 22.5%, and 5.4, respectively. In addition to achieving substantial weight loss, BS improves MetS prevalence and cardiovascular risk profiles.

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“…117 In summary, available data suggest an association between weight loss and decreased CRC incidence. Weight loss from diet alone or from BS interferes with gut microbial-host metabolic cross-talk, 121,122 and is associated with reduced metabolic syndrome 123 and lower levels of VEGF, insulin and leptin, 124 which may explain the mechanism behind these clinical observations. However, the data associating BS with CRC risk is not strong enough to support a formal indication for BS to reduce this risk.…”

Section: Obesity and Outcomes In Patients With Colorectal Cancermentioning

confidence: 99%

Review article: obesity and colorectal cancer

Bardou

Rouland

Martel

et al. 2022

Aliment Pharmacol Ther

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Summary Background Obesity is a growing global public health problem. More than half the European and North American population is overweight or obese. Colon and rectum cancers are still the second leading cause of cancer death worldwide, and epidemiological data support an association between obesity and colorectal cancers (CRCs). Aim To review the literature on CRC epidemiology in obese subjects, assessing the effects of obesity, including childhood or maternal obesity, on CRC, diagnosis, management, and prognosis, and discussing targeted prophylactic measures. Method We searched PubMed for obesity/overweight/metabolic syndrome and CRC. Other key words included ‘staging’, ‘screening’, ‘treatment’, ‘weight loss’, ‘bariatric surgery’ and ‘chemotherapy’. Results In Europe, about 11% of CRCs are attributed to overweight and obesity. Epidemiological data suggest that obesity is associated with a 30%–70% increased risk of colon cancer in men, the association being less consistent in women. Visceral fat or abdominal obesity seems to be of greater concern than subcutaneous fat obesity, and any 1 kg/m2 increase in body mass index confers more risk (hazard ratio 1.03). Obesity might increase the likelihood of recurrence or mortality of the primary cancer and may affect initial management, including accurate staging. The risk maybe confounded by different factors, including lower adherence to organised CRC screening programmes. It is unclear whether bariatric surgery helps reduce rectal cancer risk. Conclusions Despite a growing body of evidence linking obesity to CRC, many questions remain unanswered, including whether we should screen patients with obesity earlier or propose prophylactic bariatric surgery for certain patients with obesity.

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The Effect of Bariatric Surgery on Metabolic Syndrome: A Three-center Experience in Saudi Arabia

Cited by 8 publications

References 19 publications

Is the Amount of Weight Loss After Bariatric Surgery a Factor Determining Cardiometabolic Risk Reduction?

Is the Amount of Weight Loss After Bariatric Surgery a Factor Determining Cardiometabolic Risk Reduction?

Effect of Bariatric Surgery on Metabolic Syndrome, Framingham Risk Scores and Thyroid Function during One-Year Follow-Up: A Saudi Retrospective Study

Review article: obesity and colorectal cancer

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