The effect of atherogenic plasma index on collateral development in patients with chronic coronary total occlusion

Güzel, Tuncay; Bilik, Mehmet Zihni; Arslan, Bayram; Kılıç, Raif; Aktan, Adem

doi:10.30714/j-ebr.2021471924

Cited by 7 publications

(9 citation statements)

References 5 publications

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“…It abates direct toxic effects of the contrast agent on epithelial cells, decreasing the concentration and viscosity of the contrast agent in tubular lumen 18 . Hydration is usually applied to patients in all risk categories; however, it is considered a requirement in the management of patients with an eGFR <60 mL/min/1.73 m 2 . Larger volume may accelerate the elimination of contrast agent, directly reduce renal toxicity, and decrease secretion of vasoconstrictors and reactive oxygen species.…”

Section: Discussionmentioning

confidence: 99%

“…CIN was described as an increase of 0.5 mg/dL or ≥25% in serum creatinine concentration in the first 48–72 h after CAG. A glomerular filtration rate (eGFR) of <60 mL/min/1.73 m 2 , determined by Cockcroft-Gault formula, was considered renal failure.…”

Section: Methodsmentioning

confidence: 99%

“…Atherosclerosis forms the basis of coronary artery disease, and it is a progressive process accompanied by inflammation, showing systemic involvement 1 . Chronic total occlusion (CTO) of coronary arteries is described as complete occlusion of vein lumen for a minimum of 3 months (TIMI 0 flow) 2 . CTO is commonly seen in the range of 18–52% of patients undergoing coronary angiography (CAG) 3 , 4 , 5 .…”

Section: Introductionmentioning

confidence: 99%

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Relationship between contrast-induced nephropathy and long-term mortality after percutaneous coronary intervention in patients with chronic coronary total occlusion

Güzel

Aktan

Demir

et al. 2022

Rev. Assoc. Med. Bras.

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OBJECTIVE: Intervention in chronic total occlusion lesions involves long procedure time, a serious contrast load, and complex procedures. In this study, we aimed to investigate mortality rate of patients who had procedural coronary angiography done for chronic total occlusion lesions in coronary angiography series and who developed contrast-induced nephropathy. METHODS: A total of 218 patients with chronic total occlusion lesion in at least one coronary artery, from three different medical centers, who underwent procedural coronary angiography were recruited for the study. Patient population was divided into two groups: those who developed contrastinduced nephropathy and those who did not. Mortality due to all causes was investigated between both groups throughout a 100-month follow-up. RESULTS: Mean age of patients with incidence of contrast-induced nephropathy was 66.7±11.8, and 23.8% of them were comprised by female. We found a significantly higher mortality in long-term follow-up in the patient group with contrast-induced nephropathy (42.9 vs. 57.1%, p=<0.001). According to Kaplan-Meier analysis performed additionally, survival during follow-up was significantly shorter in this group and, in logistic regression analysis, it was an independent predictor of mortality (OR 11.78;. CONCLUSION: We identified that the development of contrast-induced nephropathy is associated with long-term mortality. It might be possible to reduce adverse events with prophylactic approaches before the procedure and close follow-up of such patients after the procedure.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Relationship between contrast-induced nephropathy and long-term mortality after percutaneous coronary intervention in patients with chronic coronary total occlusion

Güzel

Aktan

Demir

et al. 2022

Rev. Assoc. Med. Bras.

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“…What’s more, diabetes may affect coronary collateral development. In Guzel et al’s study, 42 there were more patients in the poor collateral group had a history of diabetes (p < 0.001). In Aktan et al’s study, 43 51 of 148 patients had diabetes, and diabetes prevalence was not determined to be statistically significant even though it was higher in the poor collateral group, which might be due to low diabetic case number.…”

Section: Discussionmentioning

confidence: 83%

Fibrinogen is Associated with Clinical Adverse Events in Patients with Psoriasis and Coronary Artery Disease

Zhao,

Zeng,

Sun

et al. 2023

JIR

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Purpose The presence of elevated fibrinogen levels is associated with cardiovascular disease. However, whether fibrinogen level is associated with adverse clinical events in patients with psoriasis and coronary artery disease (CAD) is unknown. This study aimed to investigate the relationship between fibrinogen levels and cardiovascular adverse events in these patients. Patients and Methods This retrospective cohort study collected consecutive patients with psoriasis and CAD between January 2017 and May 2022 in our hospital. The clinical records were collected, and comparisons were made between groups. The Cox regression analysis and Kaplan–Meier survival analysis were used to evaluate the association between variables. Results Of the 267 participants, one hundred and forty-seven patients (55.1%) had elevated fibrinogen levels. Compared with patients in low fibrinogen group, white blood cell and platelet counts and high-sensitivity C-reactive protein levels were higher, whereas the left ventricular ejection fraction was lower in patients in high fibrinogen group. After a median follow-up of 35.5 months, the incidence of major adverse cardiovascular events (MACEs) was higher in patients in high fibrinogen group compared with patients in low fibrinogen group (31.4% vs 16.4%, p = 0.013). The Kaplan–Meier survival curves showed the same trend (log rank p = 0.020). Subgroup analysis revealed a positive association between elevated fibrinogen levels and MACEs in patients aged <60 years (log-rank p = 0.013), those with diabetes (log-rank p = 0.027), and those who were not admitted for acute cardiovascular syndrome (log-rank p = 0.015). Conclusion Elevated fibrinogen levels were associated with adverse clinical events in patients with psoriasis and CAD, especially among patients aged <60 years, those with diabetes, and those not admitted for acute cardiovascular syndrome.

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“…Within each study, the higher the AIP, the higher the proportion of people with T2DM. For example, Guzel et al (2021) [ 37 ] found a high AIP in both groups; however, the group with 43.3% diabetics had an AIP of 0.63 ± 0.25, while the group with 25.1% diabetics had an AIP of 0.48 ± 0.25. Altogether, seven groups had a high AIP, and in such groups, the proportion of diabetics varied between 11.72% and 45.3%.…”

Section: Resultsmentioning

confidence: 99%

The Association between the Atherogenic Index of Plasma and Cardiometabolic Risk Factors: A Review

2023

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Background: Metabolic syndrome (MetS) is a condition caused by a combination of cardiometabolic risk factors (CMR). MetS leads to type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD), both of which place a burden on not only the patients but also the healthcare system. Diagnostic criteria for MetS vary, and there is no universal tool to detect it. Recently, many studies have found positive associations between the atherogenic index of plasma (AIP) and some CMR factors. Therefore, a comprehensive review was needed to recapitulate these studies and qualitatively estimate the likelihood of AIP being associated with CMR. We aimed to review and summarise observational data on AIP and CMR factors and verify their association. Materials and Methods: A review of observational studies was conducted by searching “atherogenic index of plasma” in PubMed, One Search, and the Cochrane library. A total of 2068 articles were screened, and 32 were included after excluding paediatric, non-human and interventional studies, and those carried out on cohorts with conditions unrelated to MetS or on lipid-lowering medication. The Newcastle-Ottawa scale was used to assess their quality. Results: Most studies that reported high waist circumference (WC), triglycerides (TG), insulin resistance (IR) and low high-density lipoprotein cholesterol (HDL-C) concentration, also reported high AIP. Few studies investigated blood pressure (BP) and some discrepancies existed between their results. Conclusion: AIP may be associated with WC, TG, IR, and HDL-C. It is unclear if AIP is associated with BP. The current study’s results should be used to inform futureward a meta-analysis to be seen quantitatively. It is also recommended that more cohort studies stratified by gender and ethnicity be performed to ascertain if AIP can predict MetS before it manifests.

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The effect of atherogenic plasma index on collateral development in patients with chronic coronary total occlusion

Cited by 7 publications

References 5 publications

Relationship between contrast-induced nephropathy and long-term mortality after percutaneous coronary intervention in patients with chronic coronary total occlusion

Relationship between contrast-induced nephropathy and long-term mortality after percutaneous coronary intervention in patients with chronic coronary total occlusion

Fibrinogen is Associated with Clinical Adverse Events in Patients with Psoriasis and Coronary Artery Disease

The Association between the Atherogenic Index of Plasma and Cardiometabolic Risk Factors: A Review

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