The effect of amino-functionalized mesoporous bioactive glass on MC3T3-E1 cells in vitro stimulation

Zhang, Yin; Luan, Jiapan; Jiang, Shengxiang; Zhou, Xiang; Li, Mingming

doi:10.1016/j.compositesb.2019.05.104

Cited by 33 publications

(21 citation statements)

References 42 publications

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“…S1. The enhanced release of Si from CAG compared with BAG was in accordance with a previous study ( 42 ). The hydrophilic property of amino groups on CAG may promote the Si release from hydrogels and further improve the osteogenic activity of hydrogels ( 42 ).…”

Section: Resultssupporting

confidence: 92%

“…The superior cell morphology and migration on CAG indicate that the electrostatically reinforced hydrogel has excellent biocompatibility ( 48 ). Both the optimal physical property and bioactivity of CAG contributed to the enhanced biocompatibility ( 42 , 57 ). First, the interfacial bond between organic and inorganic phases endowed CAG with a suitable porous structure, as demonstrated in the SEM analysis ( 57 ).…”

Section: Resultsmentioning

confidence: 99%

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A biopolymer hydrogel electrostatically reinforced by amino-functionalized bioactive glass for accelerated bone regeneration

et al. 2021

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Section: Resultssupporting

confidence: 92%

Section: Resultsmentioning

confidence: 99%

A biopolymer hydrogel electrostatically reinforced by amino-functionalized bioactive glass for accelerated bone regeneration

et al. 2021

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“…A similar phenomenon was reported elsewhere for Cu-doped MBGs [42]: the increased zeta potential values may be related to the elevated amounts of positively charged ions in MBGs structure as well as the quick release of the dopants used. It has been previously reported that the surface charge of MBGs have significant effects from a biological viewpoint [43][44][45]. Previous studies dealing with the zeta potential of Sr-substituted materials showed a net negative charge for the particles, which led to an improved biological performance [46].…”

Section: Discussionmentioning

confidence: 98%

Strontium- and Cobalt-Doped Multicomponent Mesoporous Bioactive Glasses (MBGs) for Potential Use in Bone Tissue Engineering Applications

et al. 2020

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Mesoporous bioactive glasses (MBGs) offer suitable platforms for drug/ion delivery in tissue engineering strategies. The main goal of this study was to prepare strontium (Sr)- and cobalt (Co)-doped MBGs; strontium is currently used in the treatment of osteoporosis, and cobalt is known to exhibit pro-angiogenic effects. Sr- and Co-doped mesoporous glasses were synthesized for the first time in a multicomponent silicate system via the sol–gel method by using P123 as a structure-directing agent. The glassy state of the Sr- and Co-doped materials was confirmed by XRD before immersion in SBF, while an apatite-like layer was detected onto the surface of samples post-immersion. The textural characteristics of MBGs were confirmed by nitrogen adsorption/desorption measurements. In vitro experiments including MTT assay, Alizarin red staining, and cell attachment and migration showed the cytocompatibility of all the samples as well as their positive effects on osteoblast-like cell line MG-63. Early experiments with human umbilical vein endothelial cells also suggested the potential of these MBGs in the context of angiogenesis. In conclusion, the prepared materials were bioactive, showed the ability to improve osteoblast cell function in vitro and could be considered as valuable delivery vehicles for therapeutics, like Co2+ and Sr2+ ions.

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“…MBGs exhibit high surface area and pore volume that enhance the in vitro bioactive response [7,8] and enable promoting the proliferation and differentiation of osteogenic related cells [9], as well as hosting different molecules with biological activity [10,11]. Furthermore, silanol groups (Si−OH) on the surface of these materials allow the functionalization with diverse groups like amines and carboxylic acids, among others, to modulate their response in the biological medium [12,13]. An additional property of these glasses is that they allow the incorporation in their structure of therapeutic ions such as copper, gallium, cerium, zinc, strontium etc.…”

Section: Introductionmentioning

confidence: 99%

Strontium-Modified Scaffolds Based on Mesoporous Bioactive Glasses/Polyvinyl Alcohol Composites for Bone Regeneration

et al. 2020

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In the search of a new biomaterial for the treatment of bone defects resulting from traumatic events, an osteoporosis scenario with bone fractures, tumor removal, congenital pathologies or implant revisions for infection, we developed 3D scaffolds based on mesoporous bioactive glasses (MBGs) (85−x)SiO2–5P2O5–10CaO–xSrO (x = 0, 2.5 and 5 mol.%). The scaffolds with meso-macroporosity were fabricated by pouring a suspension of MBG powders in polyvinyl alcohol (PVA) into a negative template of polylactic acid (PLA), followed by removal of the template by extraction at low temperature. SrO-containing MBGs exhibited excellent properties for bone substitution including ordered mesoporous structure, high textural properties, quick in vitro bioactive response in simulated body fluid (SBF) and the ability of releasing concentrations of strontium ions able to stimulate expression of early markers of osteoblastic differentiation. Moreover, the direct contact of MC3T3-E1 pre-osteoblastic cells with the scaffolds confirmed the cytocompatibility of the three compositions investigated. Nevertheless, the scaffold containing 2.5% of SrO induced the best cellular proliferation showing the potential of this scaffold as a candidate to be further investigated in vitro and in vivo, aiming to be clinically used for bone regeneration applications in non-load bearing sites.

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The effect of amino-functionalized mesoporous bioactive glass on MC3T3-E1 cells in vitro stimulation

Cited by 33 publications

References 42 publications

A biopolymer hydrogel electrostatically reinforced by amino-functionalized bioactive glass for accelerated bone regeneration

A biopolymer hydrogel electrostatically reinforced by amino-functionalized bioactive glass for accelerated bone regeneration

Strontium- and Cobalt-Doped Multicomponent Mesoporous Bioactive Glasses (MBGs) for Potential Use in Bone Tissue Engineering Applications

Strontium-Modified Scaffolds Based on Mesoporous Bioactive Glasses/Polyvinyl Alcohol Composites for Bone Regeneration

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