The effect of air pollutants on airway innate immune cells in patients with asthma

Kim, Jihyun; Kim, Young-Chan; Ham, Jongho; Sohn, Kyung Hee; Lee, Suh-Young; Chung, Doo Hyun; Cho, Sang Heon; Kang, Hye Ryun; Kim, Hye Young

doi:10.1111/all.14323

Cited by 16 publications

(16 citation statements)

References 9 publications

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“…Kim et al correlated measurements of air pollutants around patients’ houses, including particulate matter (PM), with asthma status and with the frequency of innate immune cells (ILC) in induced sputum. A significant positive correlation between the amount of PM with a diameter ≤10 µm and asthma control was reported accompanied by an increased frequency of ILC2s in induced sputum 6 …”

Section: Environmental Risk Factors For the Development Of Asthmamentioning

confidence: 93%

“…1,2 In addition, environmental factors, genetic polymorphisms, and epigenetic factors contribute to the development of asthma, heterogeneity in phenotyping, and steroid responsiveness. [3][4][5][6] Environmental interventions and exposure control can improve asthma control and exacerbations. 7 The incidence and prevalence of asthma are increasing, though regular use of inhaled corticosteroids (ICS) reduces mortality.…”

Section: Introductionmentioning

confidence: 99%

“…In the past three decades, a better understanding of distinct asthma visible properties (phenotypes) and mechanisms (endotypes) shaped better diagnostic and therapeutic tools in support of stratified/personalised interventions based on recognition of differences in responsiveness to various therapeutic interventions (theratypes) 1,2 . In addition, environmental factors, genetic polymorphisms, and epigenetic factors contribute to the development of asthma, heterogeneity in phenotyping, and steroid responsiveness 3‐6 . Environmental interventions and exposure control can improve asthma control and exacerbations 7 …”

Section: Introductionmentioning

confidence: 99%

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Advances and recent developments in asthma in 2020

Cevhertas

Öğülür

Maurer

et al. 2020

Allergy

117

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In this review, we discuss recent publications on asthma and review the studies that have reported on the different aspects of the prevalence, risk factors and prevention, mechanisms, diagnosis, and treatment of asthma. Many risk and protective factors and molecular mechanisms are involved in the development of asthma. Emerging concepts and challenges in implementing the exposome paradigm and its application in allergic diseases and asthma are reviewed, including genetic and epigenetic factors, microbial dysbiosis, and environmental exposure, particularly to indoor and outdoor substances. The most relevant experimental studies further advancing the understanding of molecular and immune mechanisms with potential new targets for the development of therapeutics are discussed. A reliable diagnosis of asthma, disease endotyping, and monitoring its severity are of great importance in the management of asthma. Correct evaluation and management of asthma comorbidity/ multimorbidity, including interaction with asthma phenotypes and its value for the precision medicine approach and validation of predictive biomarkers, are further detailed. Novel approaches and strategies in asthma treatment linked to mechanisms and endotypes of asthma, particularly biologicals, are critically appraised. Finally, due to the recent pandemics and its impact on patient management, we discuss the challenges, relationships, and molecular mechanisms between asthma, allergies, SARS-CoV-2, and COVID-19.

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Section: Environmental Risk Factors For the Development Of Asthmamentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Advances and recent developments in asthma in 2020

Cevhertas

Öğülür

Maurer

et al. 2020

Allergy

117

View full text Add to dashboard Cite

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“…9 ILC2 are more sensitive to outdoor pollution-driven proliferation than other ILC types. 10 ILC2s are deemed as steroid resistant, however, other asthma treatments might decrease their pro-inflammatory capacity. 11 An in vivo model showed that tiotropium attenuated ILC2dependent airway inflammation by suppressing IL-4 production from basophils.…”

Section: Innate Immunitymentioning

confidence: 99%

Advances and highlights in asthma in 2021

Agache

Eguiluz‐Gracia

Cojanu

et al. 2021

Allergy

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Last year brought a significant advance in asthma management, unyielding to the pressure of the pandemics. Novel key findings in asthma pathogenesis focus on the resident cell compartment, epigenetics and the innate immune system. The precision immunology unbiased approach was supplemented with novel tools and greatly facilitated by the use of artificial intelligence. Several randomised clinical trials and good quality realworld evidence shed new light on asthma treatment and supported the revision of several asthma guidelines (GINA, Expert Panel Report 3, ERS/ATS guidelines on severe asthma) and the conception of new ones (EAACI Guidelines for the use of biologicals in severe asthma). Integrating asthma management within the broader context of Planetary Health has been put forward. In this review, recently published articles and clinical trials are summarised and discussed with the goal to provide clinicians and researchers with a concise update on asthma research from a translational perspective.

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“…]10 μm and asthma control was reported accompanied by an increased frequency of ILC2s in induced sputum. 6 Recently Yang et al showed prenatal exposure to PM with an aerodynamic diameter of smaller than 10 μm (PM) has a higher association with airway hyperresponsiveness (AHR) and the risk of a new diagnosis of asthma at an early school age than current and lifetime exposure. Therefore, stricter monitoring and avoidance of exposure to PM might considerably reduce the onset of future asthma development in schoolchildren.…”

Section: Environmental Risk Factors For the Development Of Asthmamentioning

confidence: 99%

Advances and Recent Developments in Asthma in 2020

Cevhertas

Öğülür

Maurer³

et al. 2020

Preprint

View full text Add to dashboard Cite

In this review, we discuss recent publications on asthma and review the studies that have reported on the different aspects of the prevalence, risk factors and prevention, mechanisms, diagnosis and treatment of asthma. Many risk and protective factors and molecular mechanisms are involved in the development of asthma. Emerging concepts and challenges in implementing the exposome paradigm and its application in allergic diseases and asthma are reviewed, including genetic and epigenetic factors, microbial dysbiosis and environmental exposure, particularly to indoor and outdoor substances. The most relevant experimental studies further advancing the understanding of molecular and immune mechanisms with potential new targets for the development of therapeutics are discussed. A reliable diagnosis of asthma, disease endotyping and monitoring its severity are of great importance in the management of asthma. Correct evaluation and management of asthma comorbidity/multimorbidity, including interaction with asthma phenotypes and its value for the precision medicine approach and validation of predictive biomarkers are further detailed. Novel approaches and strategies in asthma treatment linked to mechanisms and endotypes of asthma, particularly biologicals, are critically appraised. Finally, due to the recent pandemics and its impact on patient management, we discuss the challenges, relationships, and molecular mechanisms between asthma, allergies, SARS-CoV-2 and Covid-19.

show abstract

The effect of air pollutants on airway innate immune cells in patients with asthma

Abstract: Isolation of cDNA encoding a newly identified major allergenic protein of rye-grass pollen: Intracellular targeting to the amyloplast .

Cited by 16 publications

References 9 publications

Advances and recent developments in asthma in 2020

Advances and recent developments in asthma in 2020

Advances and highlights in asthma in 2021

Advances and Recent Developments in Asthma in 2020

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