The effect of age of exposure on lead-induced testicular toxicity

Inhibitory Mechanisms of Lead on Steroidogenesis in Ma-10 Mouse Leydig Tumor Cells

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Inhibitory Mechanisms of Lead on Steroidogenesis in Ma-10 Mouse Leydig Tumor Cells

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Effect of soybean on bone and gonad hormones in lead intoxicated rats

“…In the rats fed on soybean in the protective and curative groups, there was a significant reduction of this hormone by 54% and 21%, respectively. In agreement with this, a large reduction in plasma and testicular testosterone has been observed by about 80% (Thoreux-Manlay et al, 1995), contrary to the findings for lower doses of lead exposure (Nathan et al, 1992;Pinon-Lataillade et al, 1993), except for those by Sokol and co-workers (Sokol et al, 1985;Sokol & Berman, 1991).…”

Effects of oral intoxication by lead acetate on pituitary-testicular axis in the pubertal rat

“…Also, our results showed a fall of about 45% in the plasma FSH after two months of exposure to lead. This was in agreement with the study of Sokol and co-workers [22] in which lead was administered at the same amount as in our study and only for one month, but was inconsistent with the results of other works [30,31,36]. The heterogeneity of the results concerning the FSH could be explained mainly by the use of different amounts of toxicant, the varied period of exposure and the multiple routes of administration of the toxicant.…”

Inhibitory Mechanisms of Lead on Steroidogenesis in Ma-10 Mouse Leydig Tumor Cells

“……”

Effect of soybean on bone and gonad hormones in lead intoxicated rats

“…In the rats fed on soybean in the protective and curative groups, there was a significant reduction of this hormone by 54% and 21%, respectively. In agreement with this, a large reduction in plasma and testicular testosterone has been observed by about 80% (Thoreux-Manlay et al, 1995), contrary to the findings for lower doses of lead exposure (Nathan et al, 1992;Pinon-Lataillade et al, 1993), except for those by Sokol and co-workers (Sokol et al, 1985;Sokol & Berman, 1991).…”

Effects of oral intoxication by lead acetate on pituitary-testicular axis in the pubertal rat

“…Also, our results showed a fall of about 45% in the plasma FSH after two months of exposure to lead. This was in agreement with the study of Sokol and co-workers [22] in which lead was administered at the same amount as in our study and only for one month, but was inconsistent with the results of other works [30,31,36]. The heterogeneity of the results concerning the FSH could be explained mainly by the use of different amounts of toxicant, the varied period of exposure and the multiple routes of administration of the toxicant.…”

Inhibitory Mechanisms of Lead on Steroidogenesis in Ma-10 Mouse Leydig Tumor Cells

“……”

Effect of soybean on bone and gonad hormones in lead intoxicated rats

“…In the rats fed on soybean in the protective and curative groups, there was a significant reduction of this hormone by 54% and 21%, respectively. In agreement with this, a large reduction in plasma and testicular testosterone has been observed by about 80% (Thoreux-Manlay et al, 1995), contrary to the findings for lower doses of lead exposure (Nathan et al, 1992;Pinon-Lataillade et al, 1993), except for those by Sokol and co-workers (Sokol et al, 1985;Sokol & Berman, 1991).…”

Effects of oral intoxication by lead acetate on pituitary-testicular axis in the pubertal rat

“…Also, our results showed a fall of about 45% in the plasma FSH after two months of exposure to lead. This was in agreement with the study of Sokol and co-workers [22] in which lead was administered at the same amount as in our study and only for one month, but was inconsistent with the results of other works [30,31,36]. The heterogeneity of the results concerning the FSH could be explained mainly by the use of different amounts of toxicant, the varied period of exposure and the multiple routes of administration of the toxicant.…”