The effect of aerobic exercise intensity on attenuation of postprandial lipemia is dependent on apolipoprotein E genotype

Ferreira, Aparecido Pimentel; Ferreira, Cristiane Batisti; Brito, Ciro José; Souza, Vinícius Carolino; Córdova, Cláudio; Nóbrega, Otávio Tolêdo; França, Nanci Maria de

doi:10.1016/j.atherosclerosis.2013.03.027

Cited by 17 publications

(17 citation statements)

References 30 publications

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“…Inter-individual variance is an alternative possibility for the inconsistent findings among studies and this issue was highlighted in one postprandial study by Thackray and colleagues where one-third of participants -5 out of 15 children -had an increase or no change in TG concentrations after exercise compared with control [36]. Apolipoprotein E genotype might also explain interindividual variance as one study found continuous moderate aerobic exercise was effective in attenuating postprandial TG only in individuals who carried the ε2 or ε3 allele but had no effect on those with the ε4 allele [13].…”

Section: Discussion ▼mentioning

confidence: 99%

Interrupting Sitting Time with Regular Walks Attenuates Postprandial Triglycerides

et al. 2015

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We compared the effects of prolonged sitting with the effects of sitting interrupted by regular walking and the effects of prolonged sitting after continuous walking on postprandial triglyceride in postmenopausal women. 15 participants completed 3 trials in random order: 1) prolonged sitting, 2) regular walking, and 3) prolonged sitting preceded by continuous walking. During the sitting trial, participants rested for 8 h. For the walking trials, participants walked briskly in either twenty 90-sec bouts over 8 h or one 30-min bout in the morning (09:00-09:30). Except for walking, both exercise trials mimicked the sitting trial. In each trial, participants consumed a breakfast (08:00) and lunch (11:00). Blood samples were collected in the fasted state and at 2, 4, 6 and 8 h after breakfast. The serum triglyceride incremental area under the curve was 15 and 14% lower after regular walking compared with prolonged sitting and prolonged sitting after continuous walking (4.73±2.50 vs. 5.52±2.95 vs. 5.50±2.59 mmol/L∙8 h respectively, main effect of trial: P=0.023). Regularly interrupting sitting time with brief bouts of physical activity can reduce postprandial triglyceride in postmenopausal women.

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Section: Discussion ▼mentioning

confidence: 99%

Interrupting Sitting Time with Regular Walks Attenuates Postprandial Triglycerides

et al. 2015

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“…Serum triglycerides (TGs), high-density lipoprotein (HDL-c), total cholesterol (TC), and glucose were analyzed by enzyme-based colorimetric methods using commercially available kits (Advia 2400, SIEMENS Healthcare Diagnostics Inc., Tarrytown, USA). The Friedewald equation was used to yield low-density lipoprotein (LDL-c) and very low-density lipoprotein (VLDL-c) estimates [ 27 ]. Serum insulin was determined by fluoroimmunoassay using a commercially available kit (Immulite 2000, SIEMENS Healthcare Diagnostics Inc., UK).…”

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confidence: 99%

Effects of a 12-Week Exercise Training Program on Physical Function in Institutionalized Frail Elderly

Ferreira¹,

Teixeira²,

Santos³

et al. 2018

Journal of Aging Research

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With the increase in life expectancy, the Brazilian elderly population has risen considerably. However, longevity is usually accompanied by problems such as the loss of functional capacity, cognitive decline, frailty syndrome, and deterioration in anthropometric parameters, particularly among those living in long-term care facilities. This randomized controlled trial aimed to verify the effects of exercise training on biochemical, inflammatory, and anthropometric indices and functional performance in institutionalized frail elderly. The sample consisted of 37 elderly people of both genders, aged 76.1 ± 7.7 years, who were randomly allocated into 2 groups: 13 individuals in the exercise group (EG) and 24 in the control group (CG). Anthropometrics, clinical history, functional tests, and biochemical evaluation were measured before and after the completion of a physical exercise program, which lasted for 12 weeks. The 12-week exercise program for frail elderly residents in a long-term care facility was efficient in improving muscle strength, speed, agility, and biochemical variables, with reversal of the frailty condition in a considerable number. However, no effects in anthropometric and inflammatory parameters were noted.

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“…Nessa mesma linha, não se observou associação entre os valores alterados de lipídios, glicemia, variáveis antropométricas e pressão arterial entre os diferentes genótipos da ApoE em uma população de idosos, verificando apenas aumento de HDL-colesterol no grupo de idosos considerados fisicamente ativos e portadores do alelo ɛ4. Todavia, os autores não puderam afirmar que esse aumento do HDL se deve ao alelo ɛ4, uma vez que a atividade física é reconhecida como uma ferramenta eficiente na melhora do HDL (11)(12)(13)(14)(15) . Na contramão dessas informações, outros estudos demonstraram que a presença do alelo ɛ4 mostrou associação forte e positiva com DCVs, como os fatores de risco cardiovasculares e com anormalidade em variáveis lipêmicas, glicêmicas e antropomé-tricas (18)(19) .…”

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“…A coleta de sangue foi realizada em tubo a vácuo, com gel separador sem anticoagulante; após a coleta, o sangue foi centrifugado por 10 minutos a 3.000 rpm para separar o soro dos demais componentes do sangue, sendo o soro utilizado para as análises. Para a genotipagem do gene da ApoE e análise bioquímica foi utilizada a mesma metodologia de outro estudo que avaliou glicemia, colesterol total, HDL, VLDL, LDL e triglicerídeos (15) . DNA total foi obtido a partir de sangue periférico por método comercial (Qiagen â ), conforme recomendações do fabricante.…”

Section: Introductionunclassified

Associação Entre O Polimorfismo Do Gene Da Apolipoproteína E E Fatores De Risco Cardiovasculares Em Idosos

Arruda¹,

Boas²,

Nóbrega³

et al. 2016

ACS

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Conflito de interesses: Não Contribuição dos autores:ALA concepção e planejamento do projeto de pesquisa. EHRVB concepção e planejamento do projeto de pesquisa. OTN redação e revisão crítica. MWMP obtenção ou análise/interpretação dos dados. JASS concepção e planejamento do projeto de pesquisa. VCS obtenção ou análise/interpretação dos dados. APF redação e revisão crítica. Contato para correspondência: Aparecido Pimentel Ferreira E-mail: cidopimentel@yahoo.com. Descritores: Idoso; Genética; Doenças Cardiovasculares. AbstractIntroduction: Aging is a physiological process characterized by a decrease in functional capacity and the increase over the incidence of diseases, especially the cardiovascular ones. Several aspects are associated with the appearance of risk factors in cardiovascular diseases in the elderly population. Among them, we highlight the genetic factors. Objective: Check the allelic variation of gene of apolipoprotein E and its association with risk factors for cardiovascular diseases in the elderly population. Patients and Methods:The sample was composed of 62 elderly living in geriatric long-term care facility in the city of Brasí-lia, Federal District. We evaluated anthropometric variables, risk factors in cardiovascular diseases, and genotype identification through DNA extraction and genotyping of ApoE. Results: The allele ɛ3ɛ3 was the most prevalent followed by allele ɛ3ɛ4, and ɛ2ɛ4, respectively. Conclusion: There was no effect of the allelic variation of ApoE in the incidence of diseases and risk factors in cardiovascular diseases diagnosed in the elderly, strengthening the influence of environmental aspects in the worsening of these conditions. It was observed the presence of a high prevalence of risk factors in cardiovascular diseases.Descriptors: Aged; Genetics; Cardiovascular Diseases. IntroduçãoO envelhecimento, considerado um processo fisiológico, progressivo e dinâmico, é caracterizado por alterações orgânicas que podem resultar em redução da capacidade de adaptação do organismo, ocasionando uma série de complicações à saúde, que aumentam as chances de perda da autonomia e de mortalidade (1)(2) . O envelhecimento parece tornar o organismo maisAssociation between gene polymorphism of apolipoprotein E and cardiovasculaes risk factors in elderly

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The effect of aerobic exercise intensity on attenuation of postprandial lipemia is dependent on apolipoprotein E genotype

Cited by 17 publications

References 30 publications

Interrupting Sitting Time with Regular Walks Attenuates Postprandial Triglycerides

Interrupting Sitting Time with Regular Walks Attenuates Postprandial Triglycerides

Effects of a 12-Week Exercise Training Program on Physical Function in Institutionalized Frail Elderly

Associação Entre O Polimorfismo Do Gene Da Apolipoproteína E E Fatores De Risco Cardiovasculares Em Idosos

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