The effect of advancing paternal age on pregnancy and live birth rates in couples undergoing in vitro fertilization or gamete intrafallopian transfer

Klonoff-Cohen, Hillary; Natarajan, Loki

doi:10.1016/j.ajog.2004.01.035

Cited by 141 publications

(121 citation statements)

References 21 publications

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“…Similar results were obtained by de La Rochebrochard and peers, where failure to conceive was observed in individuals above 40 years old [75]. Others have described diminished pregnancy rates associated with increasing male age [77]. While males 35 years old and younger exhibited pregnancy rates of 53%, men between 36 and 40 years had pregnancy rates of 35%.…”

Section: Male Age and Fecundity Problemssupporting

confidence: 75%

“…ART treatments allow the purification of high quality gametes enabling infertile couples to conceive. Similarly to what occurs during natural conceptions, pregnancy and fertilization rates seem to be decreased by APA when ART treatments are implemented [77,88]. However, most studies did not control for the mother's age bias.…”

Section: Male Age and Fecundity Problemsmentioning

confidence: 99%

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Aging of the Male Germline: Influence of Advanced Male Age on Reproductive Outcome

Rabaça¹,

Ferreira²

2016

Andrology(Los Angel)

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The rise in life expectancy and the desire to establish a stable career prior to parenthood leads couples to a delayed childbearing. Advanced parental age at the time of pregnancy portrays several risks, with the majority of couples above 35 experiencing reproductive impairments. While the effect of women's age on fertility is well known, the influence of paternal age is less understood. Thus, efforts have been made to comprehend the influence of APA on pregnancy upkeep and disease risk for the offspring. Over the last decades numerous studies aimed to establish the relationship between APA and male fertility potential. It has been found that APA is related to testicular and hormonal alterations, along with a decreased sperm production, quality and DNA integrity. As expected, these alterations compromise the reproductive potential of older men and have been associated with several fecundity problems, including increased time to pregnancy and abortion rates, and decreased fertilization and pregnancy rates. Additionally, alterations in offspring health, like genetic disorders, mental illnesses, congenital anomalies and cancer, have also been linked to APA. As a result, APA influence on the reproductive outcome must be taken into consideration when counseling couples attending family planning consultations or pursuing fertility treatments. Nonetheless, to date, there are still no definite results regarding this problem and an age threshold has yet not been established and additional research to better elucidate the effects of APA on fertility and offspring's health is needed. Likewise, establishing an age threshold for APA would be of great value to males thinking of delaying parenthood, and to physicians for medical advice purposes.

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Section: Male Age and Fecundity Problemssupporting

confidence: 75%

Section: Male Age and Fecundity Problemsmentioning

confidence: 99%

Aging of the Male Germline: Influence of Advanced Male Age on Reproductive Outcome

Rabaça¹,

Ferreira²

2016

Andrology(Los Angel)

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“…[18][19][20][21][22][23][24][25][26][27][28] Although embryo quality at the cleavage stage (days 2-3) was not affected by increasing males' age, it was associated with a significant decrease in blastocyst embryo formation, probably reflecting male genomic activation within the embryo.…”

Section: Reproductive Outcome In In Vitro Fertilization (Ivf)mentioning

confidence: 98%

Advanced paternal age and reproductive outcome

Wiener-Megnazi¹,

Auslender²,

Dirnfeld³

2011

Asian J Androl

102

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Women have been increasingly delaying the start of motherhood in recent decades. The same trend is seen also for men. The influence of maternal age on fertility, chromosomal anomalies, pregnancy complications, and impaired perinatal and post-natal outcome of offspring, has been thoroughly investigated, and these aspects are clinically applied during fertility and pregestational counseling. Male aging and reproductive outcome has gained relatively less attention. The purpose of this review is to evaluate updated and relevant literature on the effect of paternal age on reproductive outcome.

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“…The effect of paternal aging has also been studied in the setting of assisted reproductive technologies (ART). When in vitro fertilization (IVF) was examined, lower pregnancy rates and live birth rates were found in couples where the mean age of men was 38.4 [101]. Additionally, Robertshaw et al found a significantly low live birth rate with IVF for elder men (decreased by 26 % for each 5-year increase in paternal age) [102].…”

Section: Fertilization Capacitymentioning

confidence: 99%

Effects of aging on the male reproductive system

Güneş

Hekim

Arslan

et al. 2016

J Assist Reprod Genet

190

118

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The study aims to discuss the effects of aging on the male reproductive system. A systematic review was performed using PubMed from 1980 to 2014. Aging is a natural process comprising of irreversible changes due to a myriad of endogenous and environmental factors at the level of all organs and systems. In modern life, as more couples choose to postpone having a child due to various socioeconomic reasons, research for understanding the effects of aging on the reproductive system has gained an increased importance. Paternal aging also causes genetic and epigenetic changes in spermatozoa, which impair male reproductive functions through their adverse effects on sperm quality and count as, well as, on sexual organs and the hypothalamic-pituitarygonadal axis. Hormone production, spermatogenesis, and testes undergo changes as a man ages. These small changes lead to decrease in both the quality and quantity of spermatozoa. The offspring of older fathers show high prevalence of genetic abnormalities, childhood cancers, and several neuropsychiatric disorders. In addition, the latest advances in assisted reproductive techniques give older men a chance to have a child even with poor semen parameters. Further studies should investigate the onset of gonadal senesce and its effects on aging men.

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The effect of advancing paternal age on pregnancy and live birth rates in couples undergoing in vitro fertilization or gamete intrafallopian transfer

Cited by 141 publications

References 21 publications

Aging of the Male Germline: Influence of Advanced Male Age on Reproductive Outcome

Aging of the Male Germline: Influence of Advanced Male Age on Reproductive Outcome

Advanced paternal age and reproductive outcome

Effects of aging on the male reproductive system

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