The Effect of Adding Prostaglandin F2α-Isopropylester to Timolol in Patients With Open Angle Glaucoma

Differential activity and clinical utility of latanoprost in glaucoma and ocular hypertension

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Differential activity and clinical utility of latanoprost in glaucoma and ocular hypertension

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Circadian Intraocular Pressure Control with Dorzolamide versus Timolol Maleate Add-On Treatments in Primary Open-Angle Glaucoma Patients Using Latanoprost

“…Monotherapy is the preferred option for treating glaucoma, but in approximately 50% of glaucoma patients IOP could not be adequately lowered with a single drug [7] . When PGF2 ␣ analogues are combined with agents that reduce IOP by inhibiting aqueous humor secretion, like dorzolamide or timolol, they have an augmented effect [12,[32][33] . The choice of adjunctive therapy is problematic to clinicians because there is remarkably little data comparing the efficacy of adjunctive therapy with the efficacy of prostaglandin analogues.…”

Additive IOP‐reducing effect of latanoprost in patients insufficiently controlled on timolol

“…Considering the difference in mechanism of action of the two drugs, one acting on outflow and the other on inflow, one might expect them to be additive. In fact, previous studies have shown that adding PGF 2α ‐isopropyl ester to timolol further reduced IOP (Villumsen & Alm 1990; Lee et al 1991) and 60 μg/ml of latanoprost applied once daily caused a 35% reduction in IOP in patients already on timolol (Alm et al 1995). In an other study latanoprost and timolol were applied alone or combined (Rulo et al 1994).…”

Differential activity and clinical utility of latanoprost in glaucoma and ocular hypertension

“……”

Circadian Intraocular Pressure Control with Dorzolamide versus Timolol Maleate Add-On Treatments in Primary Open-Angle Glaucoma Patients Using Latanoprost

“…Monotherapy is the preferred option for treating glaucoma, but in approximately 50% of glaucoma patients IOP could not be adequately lowered with a single drug [7] . When PGF2 ␣ analogues are combined with agents that reduce IOP by inhibiting aqueous humor secretion, like dorzolamide or timolol, they have an augmented effect [12,[32][33] . The choice of adjunctive therapy is problematic to clinicians because there is remarkably little data comparing the efficacy of adjunctive therapy with the efficacy of prostaglandin analogues.…”

Additive IOP‐reducing effect of latanoprost in patients insufficiently controlled on timolol

“…Considering the difference in mechanism of action of the two drugs, one acting on outflow and the other on inflow, one might expect them to be additive. In fact, previous studies have shown that adding PGF 2α ‐isopropyl ester to timolol further reduced IOP (Villumsen & Alm 1990; Lee et al 1991) and 60 μg/ml of latanoprost applied once daily caused a 35% reduction in IOP in patients already on timolol (Alm et al 1995). In an other study latanoprost and timolol were applied alone or combined (Rulo et al 1994).…”

Differential activity and clinical utility of latanoprost in glaucoma and ocular hypertension

“……”

Circadian Intraocular Pressure Control with Dorzolamide versus Timolol Maleate Add-On Treatments in Primary Open-Angle Glaucoma Patients Using Latanoprost

“…Monotherapy is the preferred option for treating glaucoma, but in approximately 50% of glaucoma patients IOP could not be adequately lowered with a single drug [7] . When PGF2 ␣ analogues are combined with agents that reduce IOP by inhibiting aqueous humor secretion, like dorzolamide or timolol, they have an augmented effect [12,[32][33] . The choice of adjunctive therapy is problematic to clinicians because there is remarkably little data comparing the efficacy of adjunctive therapy with the efficacy of prostaglandin analogues.…”

Additive IOP‐reducing effect of latanoprost in patients insufficiently controlled on timolol

“…Considering the difference in mechanism of action of the two drugs, one acting on outflow and the other on inflow, one might expect them to be additive. In fact, previous studies have shown that adding PGF 2α ‐isopropyl ester to timolol further reduced IOP (Villumsen & Alm 1990; Lee et al 1991) and 60 μg/ml of latanoprost applied once daily caused a 35% reduction in IOP in patients already on timolol (Alm et al 1995). In an other study latanoprost and timolol were applied alone or combined (Rulo et al 1994).…”