The effect of acute exogenous melatonin on P50 suppression in healthy male volunteers stratified for low and high gating levels

Ucar, Ebru; Lehtinen, Emilia K; Glenthøj, Birte; Oranje, Bob

doi:10.1177/0269881111430752

Cited by 7 publications

(3 citation statements)

References 50 publications

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“…Baseline gating levels moderated the effects of the atypical antipsychotic sertindole, which acts as a potent antagonist at D 2 and serotonin 5-HT 2A receptors, with P50 gating being increased in healthy volunteers with low levels of gating, while attenuating sensory gating in those with high P50 suppression (Holstein et al, 2011). Also, acute administration of melatonin increased P50 ratios in high (versus low) baseline suppressors, supposedly by interaction with D 2 or nicotinic acetylcholine receptors (nAChRs) (Ucar et al, 2012).…”

Section: Baseline Dependency Of Nicotine's Sensory Gating Actions: Simentioning

confidence: 99%

Baseline dependency of nicotine’s sensory gating actions: similarities and differences in low, medium and high P50 suppressors

et al. 2013

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Reduced suppression of the P50 auditory event-related potential in schizophrenia patients relative to normal controls is indicative of a sensory gating deficit and is one of the most robust findings reported for functional brain abnormalities in this disorder. However, there is considerable gating variability in patients and controls and there is little understanding as to how inter-individual differences moderate gating responses to drugs and nicotinic agonists in particular, which have shown potential to reverse gating deficits. In this study the effects of acutely administered nicotine (gum, 6 mg) on sensory gating in a paired (S₁-S₂) auditory stimulus paradigm were investigated in 57 healthy, non-smoking volunteers stratified as low (n = 19), medium (n = 19) and high (n = 19) P50 suppressors on the basis of three separate baseline derived gating indices, P50 ratios, P50 difference scores, and gating difference waveforms. Relative to placebo, nicotine consistently improved gating in low suppressors as stratified with all three gating indices, exerted no effects in medium suppressors and reduced gating in high suppressors. Analysis of individual stimulus (S₂, S₂) amplitudes showed distinctly different mechanisms of action underlying nicotine effects in individuals with low and high baseline suppression. The results parallel similar findings of baseline-dependency in the gating effects of several antipsychotic drugs in healthy volunteers and support the use of group segmentation as a translational model in novel cognitive drug development for schizophrenia.

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Section: Baseline Dependency Of Nicotine's Sensory Gating Actions: Simentioning

confidence: 99%

Baseline dependency of nicotine’s sensory gating actions: similarities and differences in low, medium and high P50 suppressors

et al. 2013

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“…Specifically, the cholinergic antagonist scopolamine [27], and exogenous melatonin [30] have both been shown to reduce gating amplitude in normal healthy subjects. On the other hand, a stimulant, such as the adenosine antagonist theophylline, significantly increased the P50 amplitude ratio between both S2 and S1 in healthy subjects [31].…”

Section: Introductionmentioning

confidence: 99%

Sleep Extension Normalizes ERP of Waking Auditory Sensory Gating in Healthy Habitually Short Sleeping Individuals

et al. 2013

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Chronic sleep loss has been associated with increased daytime sleepiness, as well as impairments in memory and attentional processes. In the present study, we evaluated the neuronal changes of a pre-attentive process of wake auditory sensory gating, measured by brain event-related potential (ERP) – P50 in eight normal sleepers (NS) (habitual total sleep time (TST) 7 h 32 m) vs. eight chronic short sleeping individuals (SS) (habitual TST ≤6 h). To evaluate the effect of sleep extension on sensory gating, the extended sleep condition was performed in chronic short sleeping individuals. Thus, one week of time in bed (6 h 11 m) corresponding to habitual short sleep (hSS), and one week of extended time (∼ 8 h 25 m) in bed corresponding to extended sleep (eSS), were counterbalanced in the SS group. The gating ERP assessment was performed on the last day after each sleep condition week (normal sleep and habitual short and extended sleep), and was separated by one week with habitual total sleep time and monitored by a sleep diary. We found that amplitude of gating was lower in SS group compared to that in NS group (0.3 µV vs. 1.2 µV, at Cz electrode respectively). The results of the group × laterality interaction showed that the reduction of gating amplitude in the SS group was due to lower amplitude over the left hemisphere and central-midline sites relative to that in the NS group. After sleep extension the amplitude of gating increased in chronic short sleeping individuals relative to their habitual short sleep condition. The sleep condition × frontality interaction analysis confirmed that sleep extension significantly increased the amplitude of gating over frontal and central brain areas compared to parietal brain areas.

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“…Finally, we encourage future studies to examine how currently used antipsychotics for treating psychosis might influence the PG volume and MLT in parallel to changes in sleep parameters, and also consider the use of melatonin as potential treatment avenues for reducing side effects of antipsychotics [86][87][88], ameliorating various cognitive and information processing disturbances typically present in people with schizophrenia [89,90], and treating sleep disturbances in a range of psychiatric disorders, including but not limited to psychosis and mood disorder [91,92].…”

Section: Discussionmentioning

confidence: 99%

Pineal Abnormalities in Psychosis and Mood Disorders: A Systematic Review

Chauhan,

Barbanta,

Ettinger

et al. 2023

Brain Sciences

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The pineal gland (PG) is a small interhemispheric brain structure that influences human physiology in many ways, most importantly via secretion of the hormone melatonin which is known to regulate sleep and wakefulness. Here, we systematically reviewed existing neuroimaging studies of PG structure, and/or melatonin release (MLT) in psychosis and mood disorders. Medline, PubMed, and Web of Science databases were searched (on 3 February 2023), yielding 36 studies (8 PG volume, 24 MLT). The findings showed smaller-than-normal PG volume in people with schizophrenia, regardless of symptom severity and illness stage; and smaller-than-normal PG volume in major depression, with some indication of this being present only in certain subgroups, or in those with high scores on the ‘loss of interest’ symptom. There was considerable evidence of lower-than-normal MLT as well as aberrant MLT secretion pattern in schizophrenia. A similar picture, though less consistent than that seen in schizophrenia, emerged in major depression and bipolar disorder, with some evidence of a transient lowering of MLT following the initiation of certain antidepressants in drug-withdrawn patients. Overall, PG and MLT aberrations appear to represent transdiagnostic biomarkers for psychosis and mood disorders, but further work is needed to establish their clinical correlates and treatment implications.

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The effect of acute exogenous melatonin on P50 suppression in healthy male volunteers stratified for low and high gating levels

Cited by 7 publications

References 50 publications

Baseline dependency of nicotine’s sensory gating actions: similarities and differences in low, medium and high P50 suppressors

Baseline dependency of nicotine’s sensory gating actions: similarities and differences in low, medium and high P50 suppressors

Sleep Extension Normalizes ERP of Waking Auditory Sensory Gating in Healthy Habitually Short Sleeping Individuals

Pineal Abnormalities in Psychosis and Mood Disorders: A Systematic Review

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