The effect of a Titanocene Dichloride derivative, Ti IV (C5H5)2 NCS2, on the haematopoietic response of Ehrlich tumour-bearing mice

Euphorbia tirucalli L. modulates myelopoiesis and enhances the resistance of tumour-bearing mice

“…In previous study we have demonstrated that the myeloprotective properties of several natural and synthetic compounds are partially responsible for their antitumour activity in the Ehrlich ascites tumour model [16,17,20]. Clonogenic studies in EAT-inoculated mice demonstrated a rapid decrease in bone marrow CFU-GM, whereas a progressive increase in splenic CFU-GM and cellularity was observed, followed by splenomegally [10].…”

“…A therapeutic response profile of agents with antitumoral activity consists in the reversion of the profound myelosuppression, the splenic myelostimulation and the marked increase in the PGE 2 levels induced by this tumour model. Positive results are those which increase the rate or duration of survival and reduce tumoural growth in the peritoneal cavity [11,16,17].…”

Extramedular Hematopoiesis in the Spleen of Obese Mice Modulation by the Alga Chlorella

“…This involves pathophysiologic alterations in the stem cells and their microenvironment, enveloping extracellular matrix and stromal cells, in addition to local and systemic chemokine production [6]. Of importance here are our previous studies showing the relevance of the restoration of both the myelosuppression and the increased splenic EMH for recovering the homeostatic balance in the immunocompromised host, as observed during chronic inflammatory states such as infection and tumors [7][8][9][10][11][12][13][14][15][16].…”

22 Ti Anti‐Tumor Titanium Drugs

“…22 However, a recent study involving mice inoculated with Ehrlich ascites tumor has shown that the compound Cp 2 Ti IV (NCS) 2 also exhibits a reduction in anti-tumor efficacy when compared to previous results with the original titanocene dichloride. 45 In contrast to budotitane, variation of the central metal M is tolerated in the series of Cp 2 MX 2 complexes. Optimum cure rates against Ehrlich ascites tumor in mice were obtained for Ti(IV), V(IV), Nb(IV) and Mo(IV).…”