The effect of a nucleotide-nucleoside solution on hepatic regeneration after partial hepatectomy in rats

Differential expression of the genes involved in amino acids and nitrogen metabolisms during liver regeneration of mice

“…We provide here evidence that the expression of genes involving nitrogen metabolism was down‐regulated at the 1.5‐ and 4.5‐day time points after CCl 4 treatment (Fig. 2), which corresponds with the finding of the accumulation of amino acids and nucleic acids as the main nitrogenous substances in the liver several hours after PH, shown elsewhere in the literatrue 3,23 …”

“…2), which corresponds with the finding of the accumulation of amino acids and nucleic acids as the main nitrogenous substances in the liver several hours after PH, shown elsewhere in the literatrue. 3,23 Our results indicated that MAO mRNA was slightly decreased after CCl4 treatment (Fig. 4).…”

“…Further active metabolism is suppressed in order to conserve energy for cell proliferation. The metabolism of purines and pyrimidines is significantly altered in the liver following PH and exogenous supplies enhance the regenerative process 23 . A recent study shows that metabolism and transport of amino acids and their derivates were necessary in liver regeneration, as expression profiles of the genes associated were changed in rats after PH 24 …”

The nucleoside and nucleotide mixture (OG-VI) rescues intestinal-like epithelial cells from the cytotoxicity of chemotherapeutic agents

“…In the clinical field, monophosphate, as well as 22.5 mM uridine and 7.4 mM of thymidine. In the clinical setting, OG-VI is delivered parenterally (9) and in animal models, it has been shown to increase protein synthesis and improve nitrogen balance following a partial hepatectomy (9,10), as well as enhance hepatic DNA synthesis (11). OG-VI has been shown to support intestinal mucosal growth via parenteral nutrition (12,13) following massive bowel resection (14) and during fetal small bowel transplantation (15).…”

Avaliação morfológica e molecular pós-tratamento com os fatores hepatotróficos, da cirrose hepática induzida em ratas pela tioacetamida: análise a curto e longo prazo

“…Estes fatores influenciam o crescimento e trofismo hepático através de substâncias externas; sendo um recurso auxiliar na superação das limitações inerentes ao tratamento cirúrgico. Michalopoulos e DeFrances (1997); Usami et al (1996); Parra et al (1994;1995a;1995b) citam que diversas substâncias foram testadas para verificar sua influência na regeneração hepática; dentre elas, glicose, aminoácidos, lipídios, soluções de nucleotídeos e vários tipos de hormônios.…”