The Effect of a Meal and Water Loading on Heart Rate Variability in Children with Functional Dyspepsia

Friesen, Craig A.; Lin, Zhiyue; Schurman, Jennifer Verrill; Andre, Linda; McCallum, Richard W.

doi:10.1007/s10620-009-1027-6

Cited by 16 publications

(16 citation statements)

References 26 publications

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“…Friesen and colleagues [26] investigated the HRV reactivity of 9 children suffering from Rome III functional dyspepsia (FD; mean age 13 years) following a test meal or rapid water loading. They were compared to 28 healthy controls.…”

Section: Resultsmentioning

confidence: 99%

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Frequent Abdominal Pain in Childhood and Youth: A Systematic Review of Psychophysiological Characteristics

Gulewitsch

Müller

Enck³

et al. 2014

Gastroenterology Research and Practice

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Background. Frequent abdominal pain (AP) in children and adolescents is often designated as functional gastrointestinal disorder. In contrast to research on psychological and social influences on the experience of AP in this population, psychophysiological features such as function of the autonomic nervous system, the central nervous system, or the endocrine system have rarely been studied. Methods. We conducted a systematic literature search for peer-reviewed journal articles referring to children with AP between 4 and 18 years. Studies on experimental baseline characteristics or reactivity of psychophysiological outcome parameters (autonomous nervous system, central nervous system, and endocrine parameters) were included. Key Results. Twelve of 18 included studies found psychophysiological differences between children with AP and healthy ones. These studies indicate a possible autonomic dysregulation and hypersensitivity of the central nervous system in children with AP following stimulation with stress or other intense stimuli. Mainly conflicting results were found regarding baseline comparisons of autonomic and endocrine parameters. Conclusions and Inferences. Frequent AP in children may be associated with an altered psychophysiological reaction on intense stimuli. It has to be considered that the current literature on psychophysiological characteristics of childhood AP is small and heterogeneous. In particular, multiparameter studies using validated experimental paradigms are lacking.

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Section: Resultsmentioning

confidence: 99%

“…Regarding children with AP, Puzanonva and colleagues [25] and Friesen and colleagues [26] found differentiating HRV reactivity patterns following cognitive challenge or meal ingestion. In adults with IBS, only one study investigated the reactivity of the HRV.…”

Section: Discussionmentioning

confidence: 99%

Frequent Abdominal Pain in Childhood and Youth: A Systematic Review of Psychophysiological Characteristics

Gulewitsch

Müller

Enck³

et al. 2014

Gastroenterology Research and Practice

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“…There were no differences between the groups before or after the solid meal. We previously found an increased LF/HF ratio following a solid meal (but not water) in controls as opposed to patients with FD defined by Rome III criteria . In controls, SNDD increased significantly after the liquid (but not the solid) meal, but did not change after either meal in patients with FD.…”

Section: Discussionmentioning

confidence: 81%

“…There is a paucity of studies assessing autonomic responses to a meal in children and adolescents with FD. In a single study, a loss of the normal response, a postprandial shift in autonomic balance, was demonstrated in youth with FD (according to Rome III) following a solid meal; however, there was no difference between youth with FD and controls following water loading …”

Section: Introductionmentioning

confidence: 95%

Electrogastrographic and autonomic nervous system responses to solid and liquid meals in youth with functional dyspepsia

Luna

Huerta-Franco

Schurman

et al. 2020

Neurogastroenterology Motil

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Background Meal‐related symptoms are common in paediatric functional dyspepsia (FD). There are only a small number of paediatric studies assessing mechanisms for meal‐related symptoms, and these have not utilized Rome IV criteria. The aim of the current study was to assess gastric myoelectric and autonomic nervous system (ANS) responses to both liquid and solid meals in youth with Rome IV‐defined FD. Methods In healthy controls (N = 14) and youth with FD (N = 12), we recorded electrocardiograph (to assess heart rate variability; HRV) and electrogastrograph (EGG) signals before and after two test meals, one liquid and one solid. EGG parameters and HRV were assessed for the entire pre‐ and postprandial periods and in short time intervals. Additionally, liquid gastric emptying was assessed utilizing a 13C‐acetate breath test. Key Results During the EGG, the dominant power increased with both meals in controls but not patients with FD. During HRV assessment, the low frequency to high frequency ratio was higher after the liquid meal in controls, despite being similar preprandial, as compared to patients with FD. In controls, both standard deviation of normal to normal waves (SDNN) and root mean square of successive ECG R peaks (R‐R interval) differences (rMSSD) increased after the liquid meal (but not after the solid meal) in controls but not patients with FD. Conclusions and Inferences Youth with Rome IV‐defined FD lacks the normal postprandial EGG dominant power response or autonomic nervous system response following a liquid meal. The latter appears to indicate a lack of ANS flexibility.

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“…Different studies have evaluated how the hydration state may influence the sympathovagal balance and which is the effect of dehydration on the health status of athletes. Moreover, the imbalance of the autonomic nervous system in functional dyspeptic patients, and the consequent visceral hypersensitivity, has been widely demonstrated . In our study, we evaluated for the first time how dehydration, but in particular rehydration with different types of water, may influence sympathovagal balance in dyspeptic athletes and trigger the onset GI symptoms .…”

Section: Discussionmentioning

confidence: 99%

Mild dehydration in dyspeptic athletes is able to increase gastrointestinal symptoms: Protective effects of an appropriate hydration

Zito

Gala

Genovese

et al. 2018

Neurogastroenterology Motil

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Background Water balance influences gastrointestinal (GI) activity. Our aim was to evaluate how dehydration and rehydration with different types of water are able to affect GI activity in healthy and dyspeptic athletes. Methods Twenty non‐competitive athletes, respectively 10 healthy and 10 dyspeptic subjects, were enrolled. All subjects underwent three test sessions (0, A, B) of 6 hours. Dehydration was achieved with a walking/jogging exercise test on a treadmill. After exercising, 500 mL of calcium‐bicarbonate (Test A) or soft water (Test B) were administered, while no rehydration was provided during Test 0; thereafter, all subjects consumed a light lunch. GI symptoms were evaluated during each test and an electrocardiogram (ECG) Holter recording was performed at the end of the exercise. Key Results Dyspeptic subjects exhibited higher overall symptoms during Test 0 (VAS: 30.8 ± 0.8 mm) compared to Test A (18.4 ± 1.1, P < 0.001) and Test B (24.4 ± 1.3, P < 0.001). However, analyzing GI symptoms, only subjects receiving calcium‐bicarbonate water (Test A) showed significantly lower symptomatic scores compared to Test 0 or Test B. Moreover, heart rate variability analyses revealed that only in Test A dyspeptic patients exhibit a trend to a decrease in the post‐prandial low/high frequency (LF/HF) ratio, similarly to healthy subjects, while in Test 0 and Test B, post‐prandial LF/HF ratio was increased compared to the pre‐prandial phase. Conclusions and Inferences Our results show that mild dehydration in dyspeptic athletes is able to increase GI symptoms but an adequate rehydration, with calcium‐bicarbonate water, is able to improve post‐exercise disturbances restoring sympathovagal imbalance.

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The Effect of a Meal and Water Loading on Heart Rate Variability in Children with Functional Dyspepsia

Abstract: FD in children is associated with an abnormal autonomic response best demonstrated following a meal. The relationship between baseline sympathovagal balance and water load volume in FD patients is distinctly different from the relationship in control children.

Cited by 16 publications

References 26 publications

Frequent Abdominal Pain in Childhood and Youth: A Systematic Review of Psychophysiological Characteristics

Frequent Abdominal Pain in Childhood and Youth: A Systematic Review of Psychophysiological Characteristics

Electrogastrographic and autonomic nervous system responses to solid and liquid meals in youth with functional dyspepsia

Mild dehydration in dyspeptic athletes is able to increase gastrointestinal symptoms: Protective effects of an appropriate hydration

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