The effect of 12-week garlic supplementation on symptom relief in overweight or obese women with knee osteoarthritis

Salimzadeh, Ahmad; Alipoor, Elham; Dehghani, Sahar; Yaseri, Mehdi; Hosseini, Mostafa; Feinle‐Bisset, Christine; Hosseinzadeh‐Attar, Mohammad Javad

doi:10.1111/ijcp.13208

Cited by 19 publications

(22 citation statements)

References 29 publications

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“…Overall, out of 25 dietary supplements identified, 17 of them demonstrated beneficial effect on clinical signs and symptoms. These dietary supplements were krill oil (Suzuki et al, 2016), avocado/soybean unsaponifiables (ASU) (Appelboom et al, 2001), curcumin (Gianni Belcaro et al, 2010;Nakagawa et al, 2014;Panahi et al, 2014;Srivastava et al, 2016), BSE (Sengupta et al, 2008;Sengupta et al, 2010;Vishal et al, 2011), Pycnogenol (Belcaro et al, 2008a;Cisár et al, 2008;Farid et al, 2007), purple fruit passion peel (PFP) extract (Farid et al, 2010), L-carnitine (Malek Mahdavi et al, 2015;Malek Mahdavi, Mahdavi and Kolahi, 2016), Artemisia annua (ART) extract (Hunt et al, 2016), deer bone extract (DBE) (Shin et al, 2018), garlic (Dehghani et al, 2018;Salimzadeh et al, 2018), Momordica charantia (Lim et al, 2018), argan oil (Essouiri et al, 2017) pomegranate juice (PJ) (Ghoochani et al, 2016), sesame seed (Eftekhar Sadat et al, 2013), Phytalgic® (Jacquet et al, 2009), soy protein (Arjmandi et al, 2004) and calcium fructoborate (CFB) (Pietrzkowski et al, 2014). Frestedt et al (2009) reported that Aquamin supplementation is ineffective in symptoms of improvement among OA patients.…”

Section: Dietary Supplements With Positive Resultsmentioning

confidence: 99%

“…There were more female participants compared to male (69.6%:30.4%). Patients' population in studies done by Dehghani et al (2018), Malek Mahdavi, Mahdavi, and Kolahi (2016), Malek Mahdavi et al (2015 and Salimzadeh et al (2018) included only females. Only one study did not provide information regarding the gender sampled (Eftekhar Sadat et al, 2013).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Meanwhile, another cause which is the oxidative stress interrupts the cartilage homeostasis and leads to increased cartilage breakdown (Salimzadeh et al, 2018). Concurrently, reactive oxygen species (ROS) induce the synthesis of matrix-degrading enzymes and disrupt the matrix production (Im et al, 2007(Im et al, , 2008.…”

Section: Reviewmentioning

confidence: 99%

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Antioxidant and anti-inflammatory dietary supplements in the treatment of osteoarthritis: a scoping review

Ong¹,

Sakinah²,

Shahril³

et al. 2019

Food Res.

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The increasing number of evidence has reported inflammation and oxidative stress as key mediators of osteoarthritis (OA) joint pathology. Therefore, the usage of dietary supplements targeting inflammation and oxidative stress in OA may emerge as a rewarding therapeutic strategy. This study aimed to explore the efficacy of antioxidant and anti-inflammatory dietary supplements used to manage OA. A methodological framework proposed by Arksey and O’Malley was used to conduct this scoping review. An electronic database search of English academic articles was conducted using PubMed, MEDLINE and ScienceDirect from 2000 to 2018. Randomized controlled trials (RCTs) of OA with parallel groups by comparing dietary supplements with placebo consumption were eligible for inclusion. Out of 69,150 studies identified, a total of 41 studies were included, with 25 antioxidant or anti-inflammatory dietary supplements identified. There were 3325 respondents (1740 in the treatment group and 1585 in the placebo group), all aged ≥ 25 years old and comprised of 69.6% and 30.4% female and male respondents, respectively. The majority of the studies recruited participants with knee OA (n = 33) with a follow-up duration of 3 to 32 weeks. Overall, most of the dietary supplements (n =17) demonstrated a beneficial effect on the clinical signs and symptoms, such as Boswellia serrata extract (BSE), Pycnogenol and L-carnitine. In contrast, Aquamin supplementation did not exert positive impacts on OA management, while inconsistent findings were observed in greenlipped mussel (GLM) extract, vitamin E, methylsulfonylmethane (MSM), licorice flavonoid oil (LFO), ginger, willow bark extract and rose hip supplementation. In summary, the role of anti-inflammatory and antioxidant dietary supplements cannot be ignored as they can offer alleviated pain and symptom relief.

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Section: Dietary Supplements With Positive Resultsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

See 1 more Smart Citation

Antioxidant and anti-inflammatory dietary supplements in the treatment of osteoarthritis: a scoping review

Ong¹,

Sakinah²,

Shahril³

et al. 2019

Food Res.

View full text Add to dashboard Cite

show abstract

“…Forest plot presenting the standardized mean difference and 95% confidence interval for the impact of nutraceutical supplementation on VAS. 65 which supplements were administered as an adjunctive to symptomatic treatments (NSAIDs and/or analgesics) except nine of them (three 33,47,54 involved patients with knee and/or hip OA, four 24,32,44,52 involved patients with severe knee OA and two 53,55 involved patients for which supplements were administered as a monotherapy and no concomitant treatment were allowed). www.nature.com/scientificreports/ Among studies with medium term of supplementation, WOMAC total score was considerably improved through supplementation with CS in patients with mild to moderate knee OA, Deer bone extract (DBE) in patients with moderate to severe knee OA and PFP and collagen peptides isolated from pork skin (PCP) in patients with mild to severe knee OA.…”

Section: Discussionmentioning

confidence: 99%

Nutraceutical supplements in management of pain and disability in osteoarthritis: a systematic review and meta-analysis of randomized clinical trials

Aghamohammadi

Dolatkhah

Bakhtiari

et al. 2020

Sci Rep

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This study designed to evaluate the effect of nutraceutical supplementation on pain intensity and physical function in patients with knee/hip OA. The MEDLINE, Web of Science, Cochrane Library, Scopus, EMBASE, Google Scholar, Science direct, and ProQuest in addition to SID, Magiran, and Iranmedex were searched up to March 2020. Records (n = 465) were screened via the PICOS criteria: participants were patients with hip or knee OA; intervention was different nutritional supplements; comparator was any comparator; the outcome was pain intensity (Visual analogue scale [VAS]) and physical function (Western Ontario and McMaster Universities Arthritis [WOMAC] index); study type was randomized controlled trials. The random effects model was used to pool the calculated effect sizes. The standardized mean difference (SMD) of the outcome changes was considered as the effect size. The random effects model was used to combine the effect sizes. Heterogeneity between studies was assessed by Cochran's (Q) and I2 statistics. A total of 42 RCTs were involved in the meta-analysis. Nutritional supplementation were found to improve total WOMAC index (SMD = − 0.23, 95% CI − 0.37 to − 0.08), WOMAC pain (SMD = − 0.36, 95% CI − 0.62 to − 0.10) and WOMAC stiffness (SMD = − 0.47, 95% CI − 0.71 to − 0.23) subscales and VAS (SMD = − 0.79, 95% CI − 1.05 to − 0.05). Results of subgroup analysis according to the supplementation duration showed that the pooled effect size in studies with < 10 months, 10–20 months and > 20 months supplementation duration were 0.05, 0.27, and 0.36, respectively for WOMAC total score, 0.14, 0.55 and 0.05, respectively for WOAMC pain subscale, 0.59, 0.47 and 0.41, respectively for WOMAC stiffness subscale, 0.05, 0.57 and 0.53, respectively for WOMAC physical function subscale and 0.65, 0.99 and 0.12, respectively for VAS pain. The result suggested that nutraceutical supplementation of patients with knee/hip OA may lead to an improvement in pain intensity and physical function.

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“…Anti-inflammatory activity-in in vitro and animal studies, sulfurcontaining compounds from garlic exert anti-inflammatory properties through the inhibition of NF-kappa B activation (a transcription factor that regulates inflammatory response genes) and inducible nitric oxide synthase (iNOS)] and COX-2 expression. Supplementation of daily dose of either 1000 mg garlic tablet for 12 weeks improved significantly stiffness, pain, and physical function in in overweight or obese women with osteoarthritis in a clinical study Butt et al, 2009;Ban et al, 2009;Keophiphath et al, 2009;Kim et al, 2009;Salimzadeh et al, 2018 Cardiovascular health and endothelial function-garlic may slow the development of atherosclerotic process (hardening of the arteries),…”

Section: Referencesmentioning

confidence: 99%

Bioactives from culinary spices and herbs: a review

Embuscado¹

2019

JFB

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Culinary spices and herbs have been used in food and beverages to enhance aroma, flavor, and color. They are rich in phytochemicals that provide significant antioxidant and anti-inflammatory effects. There is growing interest in identifying compounds from spices and herbs responsible for modulating oxidative and inflammatory stress to prevent diet-related diseases. This contribution will provide an overview of culinary spices and herbs, their classification, their sources or origins and more importantly, their chemical composition, antioxidant activity and their impacts on human health based on important and recent studies.

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The effect of 12-week garlic supplementation on symptom relief in overweight or obese women with knee osteoarthritis

Cited by 19 publications

References 29 publications

Antioxidant and anti-inflammatory dietary supplements in the treatment of osteoarthritis: a scoping review

Antioxidant and anti-inflammatory dietary supplements in the treatment of osteoarthritis: a scoping review

Nutraceutical supplements in management of pain and disability in osteoarthritis: a systematic review and meta-analysis of randomized clinical trials

Bioactives from culinary spices and herbs: a review

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