The Effect of 100% Oxygen on the Propagation of Tracheobronchial Injury During High-Frequency and Conventional Mechanical Ventilation

Effects of different mechanical ventilation strategies on the mucociliary system

“…It seems reasonable to suppose that the ventilation is the stimulus for the production of reactive oxygen species, triggering an extrusion response from the tracheal epithelium. The decreased quantity of mucus could also be a consequence of goblet cell damage due to MV exposure [31,32]. The sample analysis of the electron microscopy performed in this work demonstrated cellular damage in the HV and HP groups, but not in the control and LV groups.…”

Effects of different mechanical ventilation strategies on the mucociliary system

“…It seems reasonable to suppose that the ventilation is the stimulus for the production of reactive oxygen species, triggering an extrusion response from the tracheal epithelium. The decreased quantity of mucus could also be a consequence of goblet cell damage due to MV exposure [31,32]. The sample analysis of the electron microscopy performed in this work demonstrated cellular damage in the HV and HP groups, but not in the control and LV groups.…”

High-Frequency Ventilation

“…Ophoven et al 138 compared the tracheal histopathology seen in animals after CMV and HFJV using different humidification systems. 55,[140][141][142][143][144][145][146][147][148] A review from the presurfactant era suggested that between 2% and 4% of HFV-treated patients have either clinical or microscopic evidence of NTB. The histologic injury patterns observed in these animals were virtually identical to those seen in human patients exposed to HFJV.…”

Tracheobronchial injury during intratracheal pulmonary ventilation in rabbits

“…All mechanical ventilation methods have been associated with a range of severity of tracheobronchial injury (13)(14)(15)(16)(17)(18)(19)(20)(21). Different mechanisms have been proposed to explain the increased airway epithelial abnormalities associated with mechanical ventilation, including inadequate humidity, excessive temperature, and the pattern and velocity of the inspiratory flow (13)(14)(15)(16)(17)(18)(19)(20)(21)(22).…”

“…Different mechanisms have been proposed to explain the increased airway epithelial abnormalities associated with mechanical ventilation, including inadequate humidity, excessive temperature, and the pattern and velocity of the inspiratory flow (13)(14)(15)(16)(17)(18)(19)(20)(21)(22). High inspired oxygen concentrations, high ventilator rates, high flow rates, and excessive tidal volumes and peak or mean airway pressures also have been shown to exacerbate tracheal injury following CMV (14) or high-frequency ventilation (13,(15)(16)(17)(18)(19)(20)(21).…”

Effects of different mechanical ventilation strategies on the mucociliary system

“…It seems reasonable to suppose that the ventilation is the stimulus for the production of reactive oxygen species, triggering an extrusion response from the tracheal epithelium. The decreased quantity of mucus could also be a consequence of goblet cell damage due to MV exposure [31,32]. The sample analysis of the electron microscopy performed in this work demonstrated cellular damage in the HV and HP groups, but not in the control and LV groups.…”

High-Frequency Ventilation

“…Ophoven et al 138 compared the tracheal histopathology seen in animals after CMV and HFJV using different humidification systems. 55,[140][141][142][143][144][145][146][147][148] A review from the presurfactant era suggested that between 2% and 4% of HFV-treated patients have either clinical or microscopic evidence of NTB. The histologic injury patterns observed in these animals were virtually identical to those seen in human patients exposed to HFJV.…”

Tracheobronchial injury during intratracheal pulmonary ventilation in rabbits

“…All mechanical ventilation methods have been associated with a range of severity of tracheobronchial injury (13)(14)(15)(16)(17)(18)(19)(20)(21). Different mechanisms have been proposed to explain the increased airway epithelial abnormalities associated with mechanical ventilation, including inadequate humidity, excessive temperature, and the pattern and velocity of the inspiratory flow (13)(14)(15)(16)(17)(18)(19)(20)(21)(22).…”

“…Different mechanisms have been proposed to explain the increased airway epithelial abnormalities associated with mechanical ventilation, including inadequate humidity, excessive temperature, and the pattern and velocity of the inspiratory flow (13)(14)(15)(16)(17)(18)(19)(20)(21)(22). High inspired oxygen concentrations, high ventilator rates, high flow rates, and excessive tidal volumes and peak or mean airway pressures also have been shown to exacerbate tracheal injury following CMV (14) or high-frequency ventilation (13,(15)(16)(17)(18)(19)(20)(21).…”

Effects of different mechanical ventilation strategies on the mucociliary system

“…It seems reasonable to suppose that the ventilation is the stimulus for the production of reactive oxygen species, triggering an extrusion response from the tracheal epithelium. The decreased quantity of mucus could also be a consequence of goblet cell damage due to MV exposure [31,32]. The sample analysis of the electron microscopy performed in this work demonstrated cellular damage in the HV and HP groups, but not in the control and LV groups.…”

High-Frequency Ventilation

“…Ophoven et al 138 compared the tracheal histopathology seen in animals after CMV and HFJV using different humidification systems. 55,[140][141][142][143][144][145][146][147][148] A review from the presurfactant era suggested that between 2% and 4% of HFV-treated patients have either clinical or microscopic evidence of NTB. The histologic injury patterns observed in these animals were virtually identical to those seen in human patients exposed to HFJV.…”

Tracheobronchial injury during intratracheal pulmonary ventilation in rabbits

“…All mechanical ventilation methods have been associated with a range of severity of tracheobronchial injury (13)(14)(15)(16)(17)(18)(19)(20)(21). Different mechanisms have been proposed to explain the increased airway epithelial abnormalities associated with mechanical ventilation, including inadequate humidity, excessive temperature, and the pattern and velocity of the inspiratory flow (13)(14)(15)(16)(17)(18)(19)(20)(21)(22).…”

“…Different mechanisms have been proposed to explain the increased airway epithelial abnormalities associated with mechanical ventilation, including inadequate humidity, excessive temperature, and the pattern and velocity of the inspiratory flow (13)(14)(15)(16)(17)(18)(19)(20)(21)(22). High inspired oxygen concentrations, high ventilator rates, high flow rates, and excessive tidal volumes and peak or mean airway pressures also have been shown to exacerbate tracheal injury following CMV (14) or high-frequency ventilation (13,(15)(16)(17)(18)(19)(20)(21).…”