The dynamics of serum thyroglobulin elimination from the body after thyroid surgery

Hočevar, Marko; Auersperg, M.; Stanovnik, Lovro

doi:10.1016/s0748-7983(97)92292-7

Cited by 71 publications

(42 citation statements)

References 12 publications

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“…[7][8][9][10][11][12][13][14] Although the half-life of Tg is long (range, 6-96 hours) compared with other proteins that are secreted by endocrine tumors and depends on liver function, Tg levels close to the tumor were significantly higher than Tg levels in the peripheral venous circulation in all but 1 patient who had lung metastasis. 15 The current results suggest that venous sampling for Tg in patients with increasing or high serum Tg levels but negative imaging studies may be useful to localize DTC.…”

Section: Discussionmentioning

confidence: 68%

Patients with differentiated thyroid cancer have a venous gradient in thyroglobulin levels

Kebebew¹,

Reiff²

2007

Cancer

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BACKGROUND.Although serum thyroglobulin (Tg) is an excellent marker for detecting recurrent or persistent differentiated thyroid cancer (DTC), it is unreliable in patients who have positive anti‐Tg antibodies. Furthermore, a growing number of patients with DTC have elevated Tg levels but no detectable disease on radioiodine scanning or other imaging studies. The objective of this study was to determine whether a gradient in Tg protein level exists in patients with DTC.METHODS.Fifteen patients who underwent thyroidectomy and/or lymph node dissection for primary DTC (n = 10 patients) and recurrent or persistent DTC (n = 5 patients). A venipuncture was performed simultaneously from the internal jugular vein adjacent to the tumor and the ipsilateral antecubital vein. Venous Tg protein levels were measured by using a chemiluminescence assay.RESULTS.The average internal jugular‐to‐antecubital vein Tg protein ratio was 3.4:1.0 (median Tg ratio, 2.9:1; range, 0.8–62.2). Four patients had positive anti‐Tg antibodies but still had a Tg gradient. Tg levels were significantly higher in the adjacent internal jugular vein than in the antecubital vein (P = .0019). The Tg ratio between the internal jugular and antecubital veins was significantly higher in patients with recurrent or persistent DTC than in patients with primary tumors (P = .0196).CONCLUSIONS.To the authors' knowledge, this is the first study to document a venous gradient in Tg protein levels in patients with DTC. The findings suggested that venous sampling for Tg may be used to localize DTC in some patients who have high or increasing serum Tg levels but negative radioiodine scans or imaging studies. Cancer 2007 © 2007 American Cancer Society.

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Section: Discussionmentioning

confidence: 68%

Patients with differentiated thyroid cancer have a venous gradient in thyroglobulin levels

Kebebew¹,

Reiff²

2007

Cancer

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“…Although the half-life of Tg is longer (range, 6-96 hours) than the other proteins secreted by endocrin tumors and is influenced by liver function, Tg levels were significantly higher in the venous samples adjacent to primary tumor than the peripheral venous circulation in 23 patients [15]. However, the other three patients had a higher Tg level in the peripheral veins.…”

Section: Discussionmentioning

confidence: 87%

Is there any venous gradient in serum thyroglobulin levels in patients with differentiated thyroid cancer?

Gülben¹,

Berberoğlu²,

Uluocak³

2010

neo

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“…Ideally, thyroglobulin should be measured at a minimum of 4 weeks after surgical resection to identify the "nadir" of thyroglobulin levels. 40 Undetectable levels or levels < 1.0 ng/mL suggest optimal surgical resection of thyroid tissue and thyroid cancer cells. The "gold standard" of thyroid cancer treatment has been to eliminate all traces of thyroglobulin in an attempt to eradicate the disease, often leading to repeated doses of I 131 for ablation.…”

Section: Radioactive Iodine Ablationmentioning

confidence: 99%

New Treatments and Shifting Paradigms in Differentiated Thyroid Cancer Management

et al. 2011

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The dynamics of serum thyroglobulin elimination from the body after thyroid surgery

Cited by 71 publications

References 12 publications

Patients with differentiated thyroid cancer have a venous gradient in thyroglobulin levels

Patients with differentiated thyroid cancer have a venous gradient in thyroglobulin levels

Is there any venous gradient in serum thyroglobulin levels in patients with differentiated thyroid cancer?

New Treatments and Shifting Paradigms in Differentiated Thyroid Cancer Management

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