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Cited by 231 publications
(168 citation statements)
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References 32 publications
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“…The latter are important, as gastrointestinal complaints are the commonest acute side effects of chemoradiotherapy for pancreatic cancer [24]. The incidence of gastrointestinal toxicity correlated best with the volume of small bowel receiving doses as low as 15 Gy [1]. Our data show a superiority of RA for all doses > 15 Gy (Figure 2).…”
Section: F-imrtmentioning
confidence: 61%
“…The latter are important, as gastrointestinal complaints are the commonest acute side effects of chemoradiotherapy for pancreatic cancer [24]. The incidence of gastrointestinal toxicity correlated best with the volume of small bowel receiving doses as low as 15 Gy [1]. Our data show a superiority of RA for all doses > 15 Gy (Figure 2).…”
Section: F-imrtmentioning
confidence: 61%
“…Although this study lacks formal radiation toxicity data, numerous studies have shown a significant correlation between the volume of the small bowel irradiated and the increased incidence of acute and late toxicity [13][14][15][16]. Baglan et al [12] showed a highly significant association between the development of acute Grade 3+ small bowel toxicity and the volume of small bowel irradiated at each dose level from 5 Gy to 40 Gy in patients receiving preoperative CRT, with the volume of small bowel receiving at least 15 Gy (v15) strongly associated with the degree of toxicity. Gunnlaugsson et al [13] similarly demonstrated a strong correlation between the occurrence of Grade 2+ diarrhoea and the irradiated small bowel volume, most notably at doses above 15 Gy.…”
Section: Discussionmentioning
confidence: 99%
“…This knowledge together with our current understanding of where rectal cancer recurs following TME and radiotherapy [7,8] suggests that standard treatment planning by the use of traditional bony landmarks is now likely to be inadequate. Furthermore, clinical data indicate that the larger the volume of small bowel irradiated the higher the risk of acute and late toxicity [9][10][11][12]. Intensity-modulated radiotherapy (IMRT) has more recently been recommended as an advanced radiotherapy planning technique to optimise a reduction in the volume of small bowel irradiated [13][14][15].…”
mentioning
confidence: 99%
“…It is shown that even large volume of low dose areas (5-15 Gy) also can cause toxicity. [19] This is a concern with using novel technologies, this is not supported by clinical studies evaluating acute GI side effects. [18] Landry et al, delivered 45 Gy for gross tumor volume and microscopic disease, and in comparison with 3DCRT, IMRT decreased the dose that one third of the small bowel receiving from 38.5 Gy vs. 30.2 Gy.…”
Section: Discussionmentioning
confidence: 99%