1997
DOI: 10.1080/109158197226874 View full text |Buy / Rent full text
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Abstract: A comprehensive effort was undertaken to identify articles demonstrating chemical hormesis. Nearly 4000 potentially relevant articles were retrieved from preliminary computer searches utilizing various keyword descriptors and extensive cross-referencing. A priori evaluation criteria were established including study design features (e.g., number of doses, dose range), statistical analysis, and reproducibility of results. Evidence of chemical hormesis was judged to have occurred in approximately 350 of the 4000 … Show more

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“…They also stated that regardless of actual response mechanisms, the similarity of dose-response characteristics likely reflected an important overall regulatory strategy built into the framework of a homeostatic control system. Calabrese and Baldwin (2003c) further noted that these collective findings closely resembled the biphasic hormetic responses to a wide range of toxic chemical agents that they had previously reported (Calabrese and Baldwin, 1997).…”
Section: Hormetic Alcohol (Ethanol)supporting
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“…They also stated that regardless of actual response mechanisms, the similarity of dose-response characteristics likely reflected an important overall regulatory strategy built into the framework of a homeostatic control system. Calabrese and Baldwin (2003c) further noted that these collective findings closely resembled the biphasic hormetic responses to a wide range of toxic chemical agents that they had previously reported (Calabrese and Baldwin, 1997).…”
Section: Hormetic Alcohol (Ethanol)supporting
“…While the hormesis database was initially designed to evaluate the nature of toxicological and pharmacological dose response relationships its utility became more broadly generalizable. The most remarkable feature of the findings of the database has been the consistent observation that the maximum stimulation response was quite limited averaging about 30-60% greater than control values (Calabrese & Baldwin 1997). The modest response also makes hormesis more difficult to replicate since the signal to noise ratio is small.…”
Section: Discussionmentioning
“…Extensive examinations of scientific literature by Calabrese and his collaborators reported that hormetic dose-responses are common across biological systems and stressors (4,6,7,8). Scientific literature provides evidence that hormesis can be caused by multiple stimuli (9), such as chemicals (4,10,11), radiation (12; 29), heat (13), stress (14), and even exercise (15).…”
Section: Introductionmentioning