The Dominant Role of <i>IL-8</i> as an Angiogenic Driver in a Three-Dimensional Physiological Tumor Construct for Drug Testing

Tan, Puay‐Hoon; Chia, Su Shin; Toh, S.L.; Goh, James Cho‐Hong; Nathan, Saminathan Suresh

doi:10.1089/ten.tea.2013.0245

Cited by 20 publications

(16 citation statements)

References 57 publications

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“…However, cisplatin‐treated cells showed a similar sensitivity due to its cell cycle–independent action. These chemosensitivity differences are largely dependent of scaffold structure and properties, confirming that 3D microenvironment and surrounding stroma directly affect cellular response . As more recently reported by Tan et al., stromal fibroblasts seem to have a positive role in angiogenesis process, promoting the upregulation of related factors like IL‐8 and VEGF‐A .…”

Section: The Current Status Of 3d Bone Cancer Modelssupporting

confidence: 70%

Three‐Dimensional Osteosarcoma Models for Advancing Drug Discovery and Development

Monteiro

Custódio

Mano

2018

Advanced Therapeutics

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Osteosarcoma (OS) is the most common primary malignant tumor of bone that mainly affects children and adolescents. The currently available therapies are not effective and the search for new OS anticancer drugs is extremely urgent. Understanding the mechanisms that underlie the tumor progression, invasion, and metastasis is an essential step toward effective cancer therapies. Tissue engineering has given a great contribution to the development of reliable and cost-effective platforms for drug screening and validation through 3D in vitro models that more faithfully mimic the in vivo pathophysiology than conventional 2D models. The progress in the field of functional and biomimetic biomaterials in the development of 3D tissue models has provided tools for a close recapitulation of the highly complex and dynamic tumor microenvironment. This review focuses on the most recent advances in 3D in vitro osteosarcoma models, highlighting the crucial role of the extracellular matrix and stromal cells in tumor progression, how they contribute to drug resistance and disease prevalence, and the future pathways toward an effective and personalized model for drug screening and validation.

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Section: The Current Status Of 3d Bone Cancer Modelssupporting

confidence: 70%

Three‐Dimensional Osteosarcoma Models for Advancing Drug Discovery and Development

Monteiro

Custódio

Mano

2018

Advanced Therapeutics

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“…Conversely, they showed that the treatment with monoclonal antibody against VEGF-A (Avastin) and IL-8 produced different results on HUVEC migration, demonstrating that anti-IL8 therapy had more efficacy on 3D U2OS/fibroblast co-culture compared to 3D U2OS monoculture, inhibiting HUVEC migration. These experiments confirmed the relevance of 3D tumor co-culture models as a preclinical model for drug testing, also promoting combined therapy against IL8 and VEGF to be used as antiangiogenic drugs [ 55 ]. In their latest scientific work, Tan et al, investigated the effects of 3D OS silk architecture on cellular proliferation and drug sensitivity and observed how 3D culture influences the proliferation rate of OS cells, bringing a reduction in comparison to 2D culture model.…”

Section: Natural Scaffoldsupporting

confidence: 54%

Relevance of 3d culture systems to study osteosarcoma environment

Luca

Raimondi

Salamanna

et al. 2018

J Exp Clin Cancer Res

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Osteosarcoma (OS) is the most common primary malignant tumor of bone, which preferentially develops lung metastasis. Although standard chemotherapy has significantly improved long-term survival over the past few decades, the outcome for patients with metastatic or recurrent OS remains dramatically poor. Novel therapies are therefore required to slow progression and eradicate the disease. Furthermore, to better understand the cellular and molecular mechanisms responsible for OS onset and progression, the development of novel predictive culture systems resembling the native three-dimensional (3D) tumor microenvironment are mandatory. ‘Tumor engineering’ approaches radically changed the previous scenario, through the development of advanced and alternative 3D cell culture in vitro models able to tightly mimic the in vivo tumor microenvironment.In this review, we will summarize the state of the art in this novel area, illustrating the different methods and techniques employed to realize 3D OS cell culture models and we report the achieved results, which highlight the efficacy of these models in reproducing the tumor milieu. Although data need to be further validated, the scientific studies reviewed here are certainly promising and give new insights into the clinical practice.

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“…Aberrant increases in IL-8 by psoriatic keratinocytes have been said to be central to their ability to produce an angiogenic response. 58 Other studies also found that the inflammatory monocyte and macrophage can be found at most sites where angiogenesis is occurring in an abnormal environment, including wound healing and disease. Activated monocytes and macrophages are sufficient to induce angiogenesis in the avascular cornea.…”

Section: Effects Of Inflammation On the Angiogenesis Are Mainly Reflementioning

confidence: 97%

“…IL‐8 is a well‐known inflammatory chemokine, and it is propitious to the proliferation and migration of EC. Aberrant increases in IL‐8 by psoriatic keratinocytes have been said to be central to their ability to produce an angiogenic response . Other studies also found that the inflammatory monocyte and macrophage can be found at most sites where angiogenesis is occurring in an abnormal environment, including wound healing and disease.…”

Section: Angiogenesis and Liver Fibrosismentioning

confidence: 99%

Update on implications and mechanisms of angiogenesis in liver fibrosis

Zhang

et al. 2014

Hepatology Research

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Liver fibrosis occurs as a compensatory response to the process of tissue repair in a wide range of chronic liver injures. It is characterized by excessive deposition of extracellular matrix in liver tissues. As the pathogenesis progresses without effective management, it will lead to formation of liver fiber nodules and disruption of normal liver structure and function, finally culminating in cirrhosis and hepatocellular carcinoma. A new discovery shows that liver angiogenesis is strictly associated with, and may even favor fibrogenic progression of chronic liver diseases. Recent basic and clinical investigations also demonstrate that liver fibrogenesis is accompanied by pathological angiogenesis and sinusoidal remodeling, which critically determine the pathogenesis and prognosis of liver fibrosis. Inhibition of pathological angiogenesis is considered to be a new strategy for the treatment of liver fibrosis. This review summarizes current knowledge on the process of angiogenesis, the relationships between angiogenesis and liver fibrosis, and on the molecular mechanisms of liver angiogenesis. On the other hand, it also presents the different strategies that have been used in experimental models to counteract excessive angiogenesis and the role of angiogenesis in the prevention and treatment of liver fibrosis.

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The Dominant Role of IL-8 as an Angiogenic Driver in a Three-Dimensional Physiological Tumor Construct for Drug Testing

Cited by 20 publications

References 57 publications

Three‐Dimensional Osteosarcoma Models for Advancing Drug Discovery and Development

Three‐Dimensional Osteosarcoma Models for Advancing Drug Discovery and Development

Relevance of 3d culture systems to study osteosarcoma environment

Update on implications and mechanisms of angiogenesis in liver fibrosis

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