The Diversity of Neurologic Events in Systemic Lupus Erythematosus

The relationship between autoimmune disorders and intracranial aneurysms in East Asian and European populations: a bidirectional and multivariable two-sample Mendelian randomization study

“…Most scholars attribute IAs to the inflammation of intracranial arteries or artery walls caused by SLE, but the specific molecular mechanisms have not been sufficiently clarified, which requires further basic experimental research. In large-scale studies on SLE in North America and Europe, the incidence of clinically defined SAH in patients with central nervous system involvement is about 0.3% (50)(51)(52)(53). A Japanese study showed that the prevalence of SLE in the Japanese population and the prevalence of SHA in SLE patients were 1.28 and 3.9%, respectively, which were higher than those in Western countries (53).…”

The relationship between autoimmune disorders and intracranial aneurysms in East Asian and European populations: a bidirectional and multivariable two-sample Mendelian randomization study

“…Most scholars attribute IAs to the inflammation of intracranial arteries or artery walls caused by SLE, but the specific molecular mechanisms have not been sufficiently clarified, which requires further basic experimental research. In large-scale studies on SLE in North America and Europe, the incidence of clinically defined SAH in patients with central nervous system involvement is about 0.3% (50)(51)(52)(53). A Japanese study showed that the prevalence of SLE in the Japanese population and the prevalence of SHA in SLE patients were 1.28 and 3.9%, respectively, which were higher than those in Western countries (53).…”

Subarachnoid hemorrhage in systemic lupus erythematosus in Japan: two case reports and a review of the literature

“…However, SAH, apart from secondary SAH due to intracerebral hemorrhage, is not common in SLE patients in Western countries. In large-scale studies on SLE in North America and Europe, the incidence of clinically defined SAH is approximately 0.3% in patients with central nervous system involvement [3,4,6,12]. Most notably, the incidence is approximately 0.1% in SLE patients younger than 50 years, and the age-and gender-adjusted risk of SAH is no higher in these relatively young SLE patients than in the general population [11].…”

Rapid aneurysm growth and rupture in systemic lupus erythematosus

“…CNS SLE indicates aggressive immunosuppression, yet the relationship between disease activity and symptoms is clear in those patients, for whom the benefits clearly outweigh the risks. [ 11 25 52 ] In contrast, given the lack of evidence linking SLE disease activity to SAH, and the likelihood that patients with aneurysm rupture will require neurosurgical intervention, maintaining SLE immunosuppressive following rupture pose a substantial risk of infection, and no defined benefit in terms of neurovascular outcome. [ 5 40 43 ] This conflict stresses the need for an understanding of the relationship between SLE vascular pathologies and SAH complications.…”

The relationship between autoimmune disorders and intracranial aneurysms in East Asian and European populations: a bidirectional and multivariable two-sample Mendelian randomization study

“…Most scholars attribute IAs to the inflammation of intracranial arteries or artery walls caused by SLE, but the specific molecular mechanisms have not been sufficiently clarified, which requires further basic experimental research. In large-scale studies on SLE in North America and Europe, the incidence of clinically defined SAH in patients with central nervous system involvement is about 0.3% (50)(51)(52)(53). A Japanese study showed that the prevalence of SLE in the Japanese population and the prevalence of SHA in SLE patients were 1.28 and 3.9%, respectively, which were higher than those in Western countries (53).…”

Subarachnoid hemorrhage in systemic lupus erythematosus in Japan: two case reports and a review of the literature

“…However, SAH, apart from secondary SAH due to intracerebral hemorrhage, is not common in SLE patients in Western countries. In large-scale studies on SLE in North America and Europe, the incidence of clinically defined SAH is approximately 0.3% in patients with central nervous system involvement [3,4,6,12]. Most notably, the incidence is approximately 0.1% in SLE patients younger than 50 years, and the age-and gender-adjusted risk of SAH is no higher in these relatively young SLE patients than in the general population [11].…”

Rapid aneurysm growth and rupture in systemic lupus erythematosus

“…CNS SLE indicates aggressive immunosuppression, yet the relationship between disease activity and symptoms is clear in those patients, for whom the benefits clearly outweigh the risks. [ 11 25 52 ] In contrast, given the lack of evidence linking SLE disease activity to SAH, and the likelihood that patients with aneurysm rupture will require neurosurgical intervention, maintaining SLE immunosuppressive following rupture pose a substantial risk of infection, and no defined benefit in terms of neurovascular outcome. [ 5 40 43 ] This conflict stresses the need for an understanding of the relationship between SLE vascular pathologies and SAH complications.…”

The relationship between autoimmune disorders and intracranial aneurysms in East Asian and European populations: a bidirectional and multivariable two-sample Mendelian randomization study

“…Most scholars attribute IAs to the inflammation of intracranial arteries or artery walls caused by SLE, but the specific molecular mechanisms have not been sufficiently clarified, which requires further basic experimental research. In large-scale studies on SLE in North America and Europe, the incidence of clinically defined SAH in patients with central nervous system involvement is about 0.3% (50)(51)(52)(53). A Japanese study showed that the prevalence of SLE in the Japanese population and the prevalence of SHA in SLE patients were 1.28 and 3.9%, respectively, which were higher than those in Western countries (53).…”

Subarachnoid hemorrhage in systemic lupus erythematosus in Japan: two case reports and a review of the literature

“…However, SAH, apart from secondary SAH due to intracerebral hemorrhage, is not common in SLE patients in Western countries. In large-scale studies on SLE in North America and Europe, the incidence of clinically defined SAH is approximately 0.3% in patients with central nervous system involvement [3,4,6,12]. Most notably, the incidence is approximately 0.1% in SLE patients younger than 50 years, and the age-and gender-adjusted risk of SAH is no higher in these relatively young SLE patients than in the general population [11].…”

Rapid aneurysm growth and rupture in systemic lupus erythematosus

“…CNS SLE indicates aggressive immunosuppression, yet the relationship between disease activity and symptoms is clear in those patients, for whom the benefits clearly outweigh the risks. [ 11 25 52 ] In contrast, given the lack of evidence linking SLE disease activity to SAH, and the likelihood that patients with aneurysm rupture will require neurosurgical intervention, maintaining SLE immunosuppressive following rupture pose a substantial risk of infection, and no defined benefit in terms of neurovascular outcome. [ 5 40 43 ] This conflict stresses the need for an understanding of the relationship between SLE vascular pathologies and SAH complications.…”