The diurnal patterns of salivary interleukin-6 and C-reactive protein in healthy young adults

Izawa, Shuhei; Miki, Keiichi; Liu, Xinxin; Ogawa, Namiko

doi:10.1016/j.bbi.2012.07.001

Cited by 101 publications

(71 citation statements)

References 20 publications

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“…TNF-α and IL-6 are key markers and mediators of systemic inflammation, which in turn have been implicated in the development of insulin resistance, T2D, cardiovascular disease, as well as in sleep disturbances (48,49). However, we did not demonstrate any differences in plasma levels or in diurnal variations in plasma TNF-α or IL-6 levels in SGA subjects with a known increased risk of developing the above-mentioned diseases.…”

Section: Discussioncontrasting

confidence: 44%

Endocrine and metabolic diurnal rhythms in young adult men born small vs appropriate for gestational age

Brøns

Saltbæk

Friedrichsen

et al. 2016

European Journal of Endocrinology

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Objective: Sleep disturbances and alterations of diurnal endocrine rhythms are associated with increased risk of type 2 diabetes (T2D). We previously showed that young men born small for gestational age (SGA) and with increased risk of T2D have elevated fat and decreased glucose oxidation rates during nighttime. In this study, we investigated whether SGA men have an altered diurnal profile of hormones, substrates and inflammatory markers implicated in T2D pathophysiology compared with matched individuals born appropriate for gestational age (AGA). Methods: We collected hourly blood samples for 24 h, to measure levels of glucose, free fatty acids (FFA), triglycerides (TG), insulin, C-peptide, leptin, resistin, ghrelin, plasminogen activator inhibitor-1 (PAI-1), incretins (GLP-1 and GIP), and inflammatory markers (TNF-α and IL-6) in 13 young men born SGA and 11 young men born AGA. Results: Repeated measurements analyses were used to analyze the diurnal variations and differences between groups. The SGA subjects had increased 24-h glucose (P = 0.03), glucagon (P = 0.03) and resistin (P = 0.003) levels with no difference in diurnal rhythms compared with AGA controls. We found significant diurnal variations in levels of blood glucose, plasma TG, FFA, insulin, C-peptide, GLP-1, GIP, leptin, visfatin, TNF-α, IL-6 and PAI-1. The variation in FFA levels differed between the groups during the evening. Plasma ghrelin and glucagon levels did not display diurnal variations. Conclusions: Young men born SGA exhibit elevated 24-h blood glucose, and plasma glucagon and resistin levels with no major differences in diurnal rhythms of these or other key metabolic hormones, substrates or inflammatory markers implicated in the origin of adiposity and T2D.

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Section: Discussioncontrasting

confidence: 44%

Endocrine and metabolic diurnal rhythms in young adult men born small vs appropriate for gestational age

Brøns

Saltbæk

Friedrichsen

et al. 2016

European Journal of Endocrinology

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“…Participants for the current study were recruited from outdoor gay community events in New Orleans, Louisiana. In order to control for the diurnal rhythm of IL-6, which reaches a daily trough between approximately 10:00 and 19:00 (Izawa, Miki, Liu, & Ogawa, 2013), participants at each event were sampled in a three-hour block between 10:00 and 13:00. Trained research assistants were strategically positioned near main routes but away from the bulk of the crowds in order to maximize opportunities to approach potential participants.…”

Section: Methodsmentioning

confidence: 99%

Minority stress and inflammatory mediators: covering moderates associations between perceived discrimination and salivary interleukin-6 in gay men

Doyle

Molix

2016

J Behav Med

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Physical health disparities by sexual orientation are widespread yet under-investigated. Drawing upon theories of biological embedding of social adversity, we tested whether minority stress (in the form of perceived discrimination) is associated with salivary interleukin-6 (IL-6), an inflammatory mediator. Furthermore, we examined whether covering, a strategy involving downplaying a stigmatized social identity, modified this association. A community sample (N = 99) of gay men (n = 78) and lesbian women (n = 21) completed self-report measures of minority stress and identity management and provided saliva samples which were assayed for IL-6. Among gay men, results from generalized linear models supported a hypothesized interaction between perceived discrimination and covering, such that perceived discrimination was predictive of higher levels of IL-6 for those who engaged in less covering but not for those who engaged in more covering. This interaction was robust to a number of potential covariates (alcohol, medication, body mass index, race and age). Results for lesbian women suggested a different pattern: the only statistically significant association detected was between greater perceived discrimination and lower levels of IL-6. Findings from the current study point to an important role for inflammatory processes in understanding and remediating health disparities based upon sexual orientation that stem from exposure to prejudice and discrimination.

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“…For CRP, the mean level was similar to the level of healthy young college students with a mean age of 21.7 years. [52] In another study with18-22 years old college students, the baseline salivary CRP level seemed far lower than ours, but the saliva collection method differed (salivette use vs. passive drool in our study), which could have affected the measurement. It is known that different saliva collection methods may produce different results.…”

Section: Biological Profilementioning

confidence: 54%

Stress-related biobehavioral profile of senior nursing students

Kang

Boss

Barrientos

et al. 2015

JNEP

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The diurnal patterns of salivary interleukin-6 and C-reactive protein in healthy young adults

Cited by 101 publications

References 20 publications

Endocrine and metabolic diurnal rhythms in young adult men born small vs appropriate for gestational age

Endocrine and metabolic diurnal rhythms in young adult men born small vs appropriate for gestational age

Minority stress and inflammatory mediators: covering moderates associations between perceived discrimination and salivary interleukin-6 in gay men

Stress-related biobehavioral profile of senior nursing students

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