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Cited by 14 publications
(8 citation statements)
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“…Ouabain is reported to activate the sympathetic autonomic nervous system and to reduce the efficiency of the baroreflex, which in turn, contributes to an increase in arterial pressure (33). In addition, hypertension has been reported to occur with enhanced sympathetic activity and a blunted baroreflex in 1K1C and DOCA-salt rats (34,35). Thus, a putative effect of ouabain potentiating this mechanism cannot be ruled out.…”
Section: Discussionmentioning
confidence: 99%
“…Ouabain is reported to activate the sympathetic autonomic nervous system and to reduce the efficiency of the baroreflex, which in turn, contributes to an increase in arterial pressure (33). In addition, hypertension has been reported to occur with enhanced sympathetic activity and a blunted baroreflex in 1K1C and DOCA-salt rats (34,35). Thus, a putative effect of ouabain potentiating this mechanism cannot be ruled out.…”
Section: Discussionmentioning
confidence: 99%
“…The 24h urinary volume was collected and measured for two days and then frozen at -80ºC. The sodium urinary contents were evaluated by a flame photometer (Bissoli et al 2000). After the experimental protocol, the serum of the animals were separated by centrifugation (3000rpm, 4ºC, 15 minutes) and kept into -80ºC.…”
Section: Biochemical Analysismentioning
confidence: 99%
“…However, the effect of AAS on this reflex has not yet been tested in females. In addition, it has been demonstrated that cardiac hypertrophy affects the ANP system (Holtwick et al 2003;Maisel et al 2002;Knowles et al 2001;Kishimoto et al 2001;Calderone et al 1998;Saito et al 1987) and that ANP affects the BJR (Bissoli et al 2000;Imaizumi et al 1987;Thorén et al 1986). Thus, we hypothesized that ND administration to female rats can alter the ANP system and the BJR.…”
Section: Introductionmentioning
confidence: 99%
“…Although hydrochlorothiazide did not significantly decrease blood pressure, the change in PI may be induced by a reflex tachycardia secondary to the small drop of blood pressure. Another possibility might be that hydrochlorothiazide directly deactivated the baroreceptors located in the carotid sinus and aorta by altering the movement of ions (19,20), and this speculation remains to be confirmed by further SBP, systolic blood pressure; DBP, diastolic blood pressure; PI, pulse interval; before, before drug administration; after, after drug administration; Sham, sham-operated rats. n = 8 in each group.…”
Section: Discussionmentioning
confidence: 99%