2010
DOI: 10.1186/1471-2407-10-255
View full text
|
|
Share

Abstract: BackgroundPoor distribution of some anticancer drugs in solid tumors may limit their anti-tumor activity.MethodsHere we used immunohistochemistry to quantify the distribution of the therapeutic monoclonal antibodies cetuximab and trastuzumab in relation to blood vessels and to regions of hypoxia in human tumor xenografts. The antibodies were injected into mice implanted with human epidermoid carcinoma A431 or human breast carcinoma MDA-MB-231 transfected with ERBB2 (231-H2N) that express high levels of ErbB1 a…

Expand abstract

Search citation statements

Order By: Relevance

Paper Sections

0
0
0
0
0

Citation Types

6
71
0

Publication Types

Select...

Relationship

0
0

Authors

Journals